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    Wyświetlanie 1-6 z 6
    Tytuł:
    Effect of magnetite composite on the amount of double strand breaks induced with X-rays
    Autorzy:
    Wiecheć, A.
    Nowicka, K.
    Błażewicz, M.
    Kwiatek, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1065182.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    87.50.-a
    87.53.-j
    81.05.Mh
    81.05.Ni
    81.05.Pj
    81.05.Qk
    75.50.Bb
    Opis:
    The aim of this study was to find out if polylactide (PLA) modified with magnetite might affect the amount of DNA double strand breaks induced with X-rays. The human osteosarcoma cells (MG63) were seeded on the polystyrene cell culture dishes (PS), PLA and PLA modified with magnetite substrates. The double strand breaks were analyzed after X-ray irradiation (dose rate 2 Gy/min), in the first day of culturing. The number of double strand breaks increased in the PLA modified with magnetite, for example after 1 Gy of X-rays irradiation, double strand breaks/cell equaled: 24.5 vs. 17.5 and 17.3, for PLA modified with magnetite vs. PLA and PS, p < 0.0003. We conclude that PLA modified with magnetite changed the number of double strand breaks induced with X-rays. However, more research is needed to confirm that such composite might be considered as radiosensitizer in radiotherapy.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 174-175
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preliminary investigations of polylactide-based nanocomposites as potential materials for bone cells proliferation
    Autorzy:
    Frączek-Szczypta, A.
    Stodolak, E.
    Wiecheć, A.
    Błażewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/283815.pdf
    Data publikacji:
    2010
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    polymer-based nanocomposite
    carbon nanotubes
    nanosilica
    Opis:
    Nanocomposite materials can be used in many application. In this study polymer–based nanocomposites modified with carbon nanotubes (CNTs) and ceramic silica nanoparticles (nSiO2) were used. Size and shape of nanoparticles were observed using transmission electron microscope (TEM). It was shown that, this parameter changes during mixing of nanoparticles with solvent or polymer solution. Dispersion of nanoparticles depends on their chemical composition. The CNTs are more compatible with polymer (PLDL) than nSiO2. Nanoparticles influence rheological parameters of the polymer solution (increase of viscosity). Distribution of nanoparticles within the polymer matrix was determined using DLS method. Nanocomposites in the form of thin foils were used for mechanical tests which show that small amount of nanoparticles increases tensile strength (Rm) and Young’s modulus (E) of the material. The biological properties of the polymer-based nanocomposite materials like viability and proliferation were measured using osteoblast-like human cells MG63. Results of these investigations show that both types of the nanocomposites are suitable for promoting bone tissue for faster regeneration process.
    Źródło:
    Engineering of Biomaterials; 2010, 13, no. 96-98; 1-3
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanocomposite coating for medical applications
    Autorzy:
    Długoń, E.
    Markowski, J.
    Plich, J.
    Wiecheć, A.
    Błażewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/285256.pdf
    Data publikacji:
    2016
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    nanocomposites
    metallic implants
    maxillofacial surgery
    Źródło:
    Engineering of Biomaterials; 2016, 19, 138; 92
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Nanocomposite Polymer Scaffolds for Bone Tissue Regeneration
    Autorzy:
    Stodolak-Zych, E.
    Frączek-Szczypta, A.
    Wiecheć, A.
    Błażewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1490208.pdf
    Data publikacji:
    2012-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    82.35.Np
    Opis:
    Nanocomposite polymer scaffolds for tissue engineering were prepared using leaching method. As a porogen there were used phosphate salts with different grain size (100-400 μm). Nanocomposite materials based on polylactide (PL/DLA) containing 2 wt% of ceramic bioactive nanoadditives $(SiO_2)$ were prepared. The nanoadditive was characterized by dynamic light scatering (DLS) (size) and the Brunauer-Emmett-Teller (specific surface area) methods. Morphology of the nanoparticles was observed using the transmission electron microscopy. The optimal concentration of the nanofiller in the polymer matrix was evaluated on the basis of in vitro tests of the nanocomposite foils contacted with osteoblast-like human cells of MG63 line. The morphology and porosity of the scaffold after leaching was evaluated using scanning electron microscopy and hydrostatic weighing. The bioactivity test made on the scaffolds demonstrated ability to nucleation of apatite structure on the material.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 2; 518-521
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Titanium Surface Modification with Carbon Nanotubes. Towards Improved Biocompatibility
    Autorzy:
    Benko, A.
    Wiecheć, A.
    Rajchel, B.
    Długoń, E.
    Błażewicz, M.
    Powiązania:
    https://bibliotekanauki.pl/articles/1398806.pdf
    Data publikacji:
    2016-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    68.37.Hk
    78.30.Na
    81.15.Pq
    82.45.Mp
    87.85.J-
    87.85.Rs
    Opis:
    Subject of this study is surface modification of titanium with thin layers of carbon nanotubes, obtained via an electrophoretic deposition, as a means to improve metal's biocompatibility and provide a suitable matrix for very facile further modifications, if needed. Article presents a preliminary evaluation of the material, using goniometer, scanning electron microscopy and the Raman spectroscopy. The layer is found to be composed of randomly distributed, strongly adhered carbon nanotubes, introducing nanotopography to the surface of titanium. Biological studies were conducted with the human osteoblast-like cell line MG63. Biocompatibility of materials was evaluated using: (a) lactate dehydrogenase cytotoxicity test (LDH) and (b) γ -H2AX genotoxicity test (presence of DNA double strand breaks). Results confirmed non-toxic character of the tested materials. Moreover, carbon nanotubes layers enhanced the biocompatibility properties of titanium substrate - material with carbon nanotubes possessed lower cellular toxic properties even than pure titanium. The result of this preliminary study are very promising and may serve as a starting point for further studies, including further chemical or biological modification of the obtained materials.
    Źródło:
    Acta Physica Polonica A; 2016, 129, 2; 176-178
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The Study of Human Osteoblast-Like MG 63 Cells Proliferation on Resorbable Polymer-Based Nanocomposites Modified with Ceramic and Carbon Nanoparticles
    Autorzy:
    Wiecheć, A.
    Stodolak-Zych, E.
    Frączek-Szczypta, A.
    Błażewicz, M.
    Kwiatek, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/1490257.pdf
    Data publikacji:
    2012-02
    Wydawca:
    Polska Akademia Nauk. Instytut Fizyki PAN
    Tematy:
    82.35.Np
    87.17.Ee
    Opis:
    Polymer-based nanocomposites containing biocompatible and bioactive nanocomponents seem to be excellent materials that could be used in many biomedical applications. The aim of this study was biological evaluation of resorbable polymer-based nanocomposites (PLA, PCL) and their modifications with ceramic nanoparticles (silica - $SiO_2$, montmorillonite - MMT) or carbon nanotubes. The nanocomposites were seeded with the human osteoblast-like MG 63 cells. After 1, 3 and 7 days of incubation, Trypan blue exclusion test was used to determine the viability and number of cells. The cell population density depending on incubation time and cell population doubling time was calculated. The cell proliferation abilities on the all applied nanocomposites and on control material (polystyrene cell culture plate) were also compared. The number of cells growing on the nanocomposite surfaces increased with the incubation time. The cell viability was not decreased for all applied materials during the entire study (97-100%). The ceramic nanoparticles and carbon nanotubes modified the bone cell growth and proliferation rate. Results of this study confirm that all types of the nanocomposites are appropriate to the growing and proliferation of human osteoblast-like cells.
    Źródło:
    Acta Physica Polonica A; 2012, 121, 2; 546-550
    0587-4246
    1898-794X
    Pojawia się w:
    Acta Physica Polonica A
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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