- Tytuł:
- New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1-hydroxyethane-1,1-diyl) diphosphonic acid (HEDP)
- Autorzy:
- Assaad, T.
- Powiązania:
- https://bibliotekanauki.pl/articles/971536.pdf
- Data publikacji:
- 2016
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
aminoethylidenediphosphonic acid
biodistribution
bisphosphonates
bone imaging agent
radiolabeling - Opis:
- A novel bisphosphonate derivative (1-aminoethane-1,1-diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields. The in vivo biodistribution of 99mTc-AEDP has been investigated and compared with two reference compounds Tc-99m methylene diphosphonate (99mTc-MDP) and Tc-99m (1-hydroxyethylidene) diphosphonate (99mTc-HEDP). The biodistribution studies have demonstrated a high uptake of the radiotracer 99mTc-AEDP in the bone and a rapid clearance from the blood (such as the two technetium-labeled bone imaging agents in current use: 99mTc-MDP and 99mTc-HEDP). Additionally, the scintigraphic images of 99mTc-AEDP in normal rats have revealed high selective skeletal uptake.
- Źródło:
-
Nukleonika; 2016, 61, 1; 69-74
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł