- Tytuł:
- Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars
- Autorzy:
-
Sugiyama, M.
Yamashita, M.
Yu, G.
Fujie, M.
Ogawa, K.
Ozaki, N.
Aoki, T.
Mizuno, S.
Okada, S.
Tachi, K.
Aoshima, K.
Sankar, U. R.
Kumar, B. S.
Takehara, Y.
Sakahara, H. - Powiązania:
- https://bibliotekanauki.pl/articles/385252.pdf
- Data publikacji:
- 2009
- Wydawca:
- Sieć Badawcza Łukasiewicz - Przemysłowy Instytut Automatyki i Pomiarów
- Tematy:
-
MRI contrast agent
Gd(III)-DTPA
tumor imaging - Opis:
- MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.
- Źródło:
-
Journal of Automation Mobile Robotics and Intelligent Systems; 2009, 3, 4; 191-194
1897-8649
2080-2145 - Pojawia się w:
- Journal of Automation Mobile Robotics and Intelligent Systems
- Dostawca treści:
- Biblioteka Nauki
Artykuł