- Tytuł:
- Genomics and the evolution of aminoacyl-tRNA synthesis.
- Autorzy:
-
Ruan, Benfang
Ahel, Ivan
Ambrogelly, Alex
Becker, Hubert
Bunjun, Shipra
Feng, Liang
Tumbula-Hansen, Debra
Ibba, Michael
Korencic, Dragana
Kobayashi, Hiroyuki
Jacquin-Becker, Clarisse
Mejlhede, Nina
Min, Bokkee
Raczniak, Gregory
Rinehart, Jesse
Stathopoulos, Constantinos
Li, Tong
Söll, Dieter - Powiązania:
- https://bibliotekanauki.pl/articles/1044116.pdf
- Data publikacji:
- 2001
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
evolution
tRNA
aminoacyl-tRNA
translation
protein synthesis - Opis:
- Translation is the process by which ribosomes direct protein synthesis using the genetic information contained in messenger RNA (mRNA). Transfer RNAs (tRNAs) are charged with an amino acid and brought to the ribosome, where they are paired with the corresponding trinucleotide codon in mRNA. The amino acid is attached to the nascent polypeptide and the ribosome moves on to the next codon. Thus, the sequential pairing of codons in mRNA with tRNA anticodons determines the order of amino acids in a protein. It is therefore imperative for accurate translation that tRNAs are only coupled to amino acids corresponding to the RNA anticodon. This is mostly, but not exclusively, achieved by the direct attachment of the appropriate amino acid to the 3'-end of the corresponding tRNA by the aminoacyl-tRNA synthetases. To ensure the accurate translation of genetic information, the aminoacyl-tRNA synthetases must display an extremely high level of substrate specificity. Despite this highly conserved function, recent studies arising from the analysis of whole genomes have shown a significant degree of evolutionary diversity in aminoacyl-tRNA synthesis. For example, non-canonical routes have been identified for the synthesis of Asn-tRNA, Cys-tRNA, Gln-tRNA and Lys-tRNA. Characterization of non-canonical aminoacyl-tRNA synthesis has revealed an unexpected level of evolutionary divergence and has also provided new insights into the possible precursors of contemporary aminoacyl-tRNA synthetases.
- Źródło:
-
Acta Biochimica Polonica; 2001, 48, 2; 313-321
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł