- Tytuł:
- Preparation and biological evaluation of [61Cu]bleomycin complex as a possible PET radiopharmaceutical in normal and fibrosarcoma-bearing animals
- Autorzy:
-
Jalilian, A. R.
Zandi, H.
Sardari, D.
Akhlaghi, M.
Kamali-Dehghan, M.
Shafaei, K.
Majdabadi, A. - Powiązania:
- https://bibliotekanauki.pl/articles/148090.pdf
- Data publikacji:
- 2009
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
radiopharmaceutical
copper-61
bleomycin
positron emission tomography
fibrosarcoma - Opis:
- [61Cu]bleomycin ([61Cu]BLM) was prepared using [61Cu]CuCl2 produced via natZn(p,x)61Cu. [61Cu]BLM was prepared under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 92.5–370 MBq 61CuCl2) with radiochemical purity over 98% shown by HPLC and RTLC. [61Cu]BLM was administered into normal and tumor bearing rodents up to 210 min followed by biodistribution and co-incidence imaging studies. A significant tumor/non tumor accumulation was observed either by animal sacrification or an imaging method. [61Cu]BLM can be a potential PET radiotracer for tumor imaging.
- Źródło:
-
Nukleonika; 2009, 54, 2; 135-141
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł