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Tytuł:
Neoadjuvant therapy in breast cancer – objectives and tasks
Autorzy:
Ostańska, Elżbieta
Bartusik-Aebisher, Dorota
Aebisher, David
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454710.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
neoadjuvant therapy (NCT)
breast cancer (BC)
triple negative breast cancer (TNBC)
Opis:
Introduction. Neoadiuvant therapy (NCT) in the treatment of breast cancer is employed for patients with early stage disease or with inoperable disease. NCT can decrease the tumor volume. It can facilitate breast conservation therapy. Response to NCT is a strong predictor of outcome breast cancer (BC). Direct target therapies has markedly improved the result of treatment BC. Aim. Therapy for breast cancer continues to improve. The importance of tumor burden on local control rates will be in the future. Material and methods. This analysis was performed using a systematic literature search. Results. The latest scientific reports give hope for greater safety and a better life for patients based on optimized and effective therapy. Conclusion. Currently, improving the effectiveness of breast cancer treatment is mainly related to the optimal use of classic therapeutic strategies. New classes of substances have been approved for treatment or are in advanced stages of clinical development.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 153-156
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Treating kidney cancer – a review
Autorzy:
Przyczyna, Piotr
Aebisher, David
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454983.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
kidney cancer
malignant tumors
MRI
Opis:
Introduction. Kidney cancer in the structure of registered cases was in 6th place in men and 8th in women. Aim. Understanding the molecular biology of renal cell carcinoma has made it possible to produce new diagnostic methods. Material and methods. This review was performed according to a systematic literature search. Results. Minimally invasive techniques seem to have a bright future in kidney cancer. However, they still require many clinical trials before they enter the general clinical use. Conclusion. Photodynamic therapy, thanks to research conducted in kidney cancer, will find application in cancer of other organs.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 38-41
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging studies of kidney cancer
Autorzy:
Przyczyna, Piotr
Aebisher, David
Gustalik, Joanna
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/1597349.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
Kidney cancer
MRI
PET
Opis:
In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 4; 334-337
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Mixed adenocarcinoma-neuroendocrine cancer – a case report
Autorzy:
Gustalik, Joanna
Aebisher, David
Kaznowska, Ewa
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/2040147.pdf
Data publikacji:
2020-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
central nervous system
MANEC
mixed adenocarcinoma-neuroendocrine cancer
Opis:
Introduction. Mixed adenocarcinoma-neuroendocrine cancer (MANEC) is a rare cancer that is characterized by aggressive course and poor prognosis. Aim. A case report and literature review. Description of the case. This article presents the case of a 63-year-old patient who was hospitalized due to the occurrence of neurological symptoms such as nausea, dizziness and headache as well as double vision and numbness of the hands. Suspected ischemic stroke, meningitis with bacterial etiology or brainstem pathology. Conclusion. MANEC composed of large neuroendocrine cells have better survival and clinical behavior than patients with small, intermediate or mixed large and intermediate cells.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 4; 335-337
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Imaging methods of early detection and screening for breast cancer. A review
Autorzy:
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Aebisher, David
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454888.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
breast MRI
early detection
screening
Opis:
Introduction. Breast cancer is the most frequent neoplasm among women. That is the reason why scientists all over the world are attempting to improve early detection methods of this particular malignancy. Aim. The most common and most widely used examination methods for screening for and detecting breast cancer is presented herein. Material and methods. This review was performed according to systematic literature search of three major bibliographic databases. Results. Available data suggest that incidence and mortality in high-resource countries has been declining whereas incidence and mortality in low-resource countries has been increasing. Conclusion. The role of a physician is to select the most suitable one for each patient in order to obtain the best result. No matter the method however, between 2005 and 2011, the 5-year relative survival was found to be 89%. This is thought to be due to both the increase in utilization of population-wide screening, as well as advances in treatment.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 142-145
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lycopene activity on lung and kidney cancer cells by T2 relaxation time 1 H Magnetic Resonance Imaging in vitro
Autorzy:
Pogoda, Katarzyna
Pucka, Maria
Tabarkiewicz, Jacek
Bober, Zuzanna
Aebisher, David
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/454731.pdf
Data publikacji:
2020-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cell cultures
lung cancer
lycopene
kidney cancer
magnetic resonance imaging relaxation times
Opis:
Introduction. The paper presents the results of a study of cell cultures of lung cancer and kidney cancer using lycopene performed using clinical magnetic resonance imaging. Aim. The aim of the study was to evaluate lycopene activity on tumor cell cultures. Material and methods. For this purpose, MR tests were performed using the technique of determining transverse relaxation. Results. Described here studies demonstrated that lycopene may inhibit the growth of A549 and ACHN cell lines. Conclusion. We determine changes in spin lattice relaxavity T2 to monitor treatment of lung cancer cell line A549 and kidney cancer cell line ACHN cells treatment with lycopene.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 1; 5-9
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Epidemiology of breast cancer in Podkapackie voivodship
Autorzy:
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Ostańska, Elżbieta
Przyczyna, Piotr
Osuchowski, Michał
Aebisher, David
Galiniak, Sabina
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454657.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
breast cancer
statistics
epidemiology
podkarpackie voivodship
Opis:
Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 3; 242-245
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
MRI as a potential tool for monitoring of therapeutic monoclonal antibody distribution in cancer patients
Autorzy:
Tabarkiewicz, Jacek
Aebisher, David
Bartusik-Aebisher, Dorota
Powiązania:
https://bibliotekanauki.pl/articles/895617.pdf
Data publikacji:
2020-06-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
monoclonal antibody
magnetic resonance imaging
fluorine
cancer diagnostics
Opis:
Imaging and quantification of MAbs distribution by MRI after administration in vivo can improve patient outcomes, although it is not routinely used in the clinic hence the motivation for development of new MAbs imaging methodologies. Improvements in imaging and quantification of antibody distributions can be made by conjugating MAbs to “hotspot” atoms such as 19F as 19F Currently, research investigating the incorporation of 19F to antibody delivery systems has been limited to trastuzumab perfluorocarbon emulsions and this method has not been extended to other clinically approved antibodies. The methodologies of 19F MRI can improve current limitations of antibody immunotherapy such as quantitative visualization of targeted surface antigens expressed on tumor cells.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 3; 383-389
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of new biomarkers for the diagnosis and treatment of colon cancer
Autorzy:
Czarnecka-Czapczyńska, Magdalena
Bartusik-Aebisher, Dorota
Krupka-Olek, Magdalena
Aebisher, David
Cieślar, Grzegorz
Latos, Wojciech
Kawczyk-Krupka, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/2040510.pdf
Data publikacji:
2021-12-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
colon cancer
diagnosis
treatment
Opis:
Introduction. Colorectal cancer may be benign or malignant. According to the World Health Organization and CDC, it is the second most common cancer worldwide, after lung cancer. The mortality of colorectal cancer has been dropping for more than 20 years due to the improvements in screening techniques and treatments. Aim. The aim of this article is to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Material and methods. This article is a review done in regards to discuss the role of new biomarkers for the diagnosis and treatment of colon cancer. Analysis of the literature. A review is discussed the role of new biomarkers for the diagnosis and treatment of colon cancer using current literature. Conclusion. The screening tests based on diagnostic new biomarkers may cause faster detection of cancer and risk factors, and provide prognostic information in order to adjust individual therapy.
Źródło:
European Journal of Clinical and Experimental Medicine; 2021, 4; 326-329
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effect of photodynamic therapy with hypericin on the secretion of selected cytokines of colorectal cancer cells tested in vitro
Autorzy:
Międzybrodzka, Anna
Kawczyk-Krupka, Aleksandra
Aebisher, David
Cieślar, Grzegorz
Czuba, Zenon Paweł
Powiązania:
https://bibliotekanauki.pl/articles/25102362.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
colorectal cancer
hypericin
photodynamic therapy
Opis:
Introduction and aim. Photodynamic therapy is a complex process involving the introduction of photosensitizers into the patient’s body and irradiation of them in order to destroy the lesion, and activate the immune system. An important role in photodynamic therapy is played by photobiochemical and physical mechanisms that affect the tumor vessels and lead to the death of the damaged cell. The aim of the study is to determine the effect of photodynamic therapy with the use of Hypericin (Hyp) on the secretion of selected cytokines by colorectal cancer cells. Material and methods. Two colorectal cancer cell lines SW480 and SW620 were used in the study. Cells treated Hypericin were exposed to visible light. Then cell viability was determined by the MTT assay with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium. Assays were performed for control samples without hypericin and light exposure, with Hyp without light exposure, without Hyp and irradiated with light, and test samples with Hyp and light exposure. Results. In the experiment we reveal, that Hyp- photodynamic activity does not influence the secretion of cytokines. Conclusion. The obtaining results confirming the destructive effect of Hyp- PDT on the colon cancer cells, show a possibility of extending the indication for photodynamic therapy using Hyp, qualification of precancerous changes.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 194-201
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of hypericin-mediated photodynamic therapy on GM-CSF, MIF, VCAM-1 and ICAM-1 secretion in colorectal cancer cells in vitro
Autorzy:
Międzybrodzka, Anna
Kawczyk-Krupka, Aleksandra
Aebisher, David
Cieślar, Grzegorz
Czuba, Zenon Paweł
Powiązania:
https://bibliotekanauki.pl/articles/25102366.pdf
Data publikacji:
2023-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
colorectal cancer
hypericin
photodynamic therapy
Opis:
Introduction and aim. Photodynamic therapy with hypericin (HYP-PDT) is gaining importance as a potential treatment method for malignant neoplasms. The following study investigated whether HYP-PDT influences the secretion of certain factors of colon cancer cells in vitro. Material and methods. Two colon cancer cell lines were used in this experiment: SW480 and SW620. The cells were properly prepared and then treated with photodynamic therapy with hypericin at concentrations of 0.25 µM and 0.5 µM and irradiation at the doses of 1 J/cm2 , 5 J/cm2 and 10 J/cm2 . After using HYP-PDT, changes in the concentrations of four factors: GM-CSF, MIF, VCAM-1 and ICAM-1 were analyzed in the test tubes. Results. In the case of SW480 cells: a notable decrease in GM-CSF, MIF, VCAM-1 and ICAM-1 secretion was noted after HYP-PDT. In the case of SW620 cells, after HYP-PDT: no effect on GM-CSF secretion was noted; it inhibited the secretion of VCAM-1 and MIF and increased the secretion of ICAM-1. Conclusion. Photodynamic therapy with hypericin shows immunomodulatory potential in an in vitro cell line experiments. This may indicate its possible ability to modify the course of malignant tumors and therefore requires further research.
Źródło:
European Journal of Clinical and Experimental Medicine; 2023, 2; 202-216
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of MR relaxation times following trastuzumab treatment of breast cancer cells in a 3D bioreactor
Autorzy:
Bartusik-Aebisher, Dorota
Aebisher, David
Czmil, Anna
Mazur, Damian
Powiązania:
https://bibliotekanauki.pl/articles/895234.pdf
Data publikacji:
2020-02-29
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
magnetic resonance imaging (MRI)
breast cancer cell cultures
hollow-fiber bioreactor (HFBR)
relaxation time maps
Opis:
The three dimensional tumor environment can be mimicked with the use of cells cultured within a hollow-fiber bioreactor (HFBR). In this work, magnetic resonance imaging (MRI) was used to monitor changes in relaxation time in breast cancer cells following treatment with Trastuzumab in a HFBR system. Breast cancer cells were inoculated into the HFBR system and cultured over a period of 4 weeks. Relaxation time maps were generated according to MRI techniques in three dimensional (3D) cultures of MCF7/Her2 breast cancer and MCF7/Neo4 control cells. MRI measurements showed a variation in values of spin-lattice (T1) and spin-spin (T2) relaxation times related to cell density. Differences in both values (T1 and T2) were noted between untreated cells and cells treated with trastuzumab in the HFBR device. Additionally, 1H MRI was able to provide information about drug penetration in breast cancer cell culture organized in 3D. In conclusion, MRI in vitro can provide direct, noninvasive visualization of cell density in 3D geometry and cell viability as a function of drug uptake. Both T1 and T2 values were higher for lower cell density and accordingly both values, T1 and T2, were lower for higher cell density.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2020, 77, 1; 35-41
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Glycosaminoglycan concentration in cancer tissue
Autorzy:
Bar, Piotr
Galiniak, Sabina
Bartusik-Aebisher, Dorota
Filip, Rafał
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/454799.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
fixed charge density glycosaminoglyca
magnetic resonance imaging
Opis:
Introduction. Glycosaminoglycans (GAGs) play a widespread role in tissue modelling. GAG polymers may affect several receptor pathways in parallel. Aim. To present difference in concentration of GAG in healthy and cancer tissues. Material and methods. The literature search was performed nd reviewed using selected keywords. Results. We revieved the methods of detection various types of glycans measured by Magnetic Resonance Imaging. Conclusion. MRI methodology provides an efficient tool forstudy of cellular composition. The use T1 aof T2 measurements to study cancer tissue is a promising assay.
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 2; 175-178
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The advancement of imaging in diagnosis of prostate cancer
Autorzy:
Osuchowski, Michał
Aebisher, David
Gustalik, Joanna
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Powiązania:
https://bibliotekanauki.pl/articles/454680.pdf
Data publikacji:
2019
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
MRI
PET
prostate carcinoma
Opis:
Introduction. Multiple imaging methods have been used to stage prostate carcinoma. Some of them are easily accessible, others very accurate. The advancements over many years have been taken under consideration and now every imaging method has a specific role in the diagnosis of this malignancy. Aim. There are over 1,100,000 cases of prostate carcinoma diagnosed every year around the world. Imaging examinations have to be introduced to accurately stage, and therefore properly treat this disease. This review concentrates on advantages and disadvantages of different imaging methods. Material and methods. The literature search was performed. Results. Imaging methods serve specific goals. TRUS is recommended for acquiring biopsy specimen due to high accessibilityand low cost of the examination. Conclusion. The best tool for staging prostate carcinoma and finding suspicious lesions when attempting second biopsy is mpMRI or bpMRI
Źródło:
European Journal of Clinical and Experimental Medicine; 2019, 1; 67-70
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hyalinising clear cell carcinoma of salivary gland: a case report
Autorzy:
Osuchowski, Michał
Bartusik-Aebisher, Dorota
Kaznowska, Ewa
Aebisher, David
Powiązania:
https://bibliotekanauki.pl/articles/2037686.pdf
Data publikacji:
2020-06-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
cancer
hyalinising clear cell carcinoma salivary gland
Opis:
Introduction. Clear cell carcinoma, not otherwise specified/hyalinising clear cell carcinoma of the salivary gland (HCCC) is a malignancy that arises in minor salivary glands. It rarely leads to distant metastases or cancer-related death but has the potential for recurrence and focal metastases. Aim. A case is reported. Description of the case. A 72 years old female patient has reported to the Clinic of Otolaryngology with a tongue lesion. The patient had no history of malignancy. The lymph node has been surgically removed for further examination. Cords and nests of clear cells and cells with eosinophilic cytoplasm in a hyalinized stroma were identified within the lymph node. After the diagnosis the patient has been transferred to another Oncology Hospital for further treatment. Conclusion. The diagnosis of clear cell carcinoma may be challenging because many of it‘s features frequently overlap with other salivary gland lesions.
Źródło:
European Journal of Clinical and Experimental Medicine; 2020, 2; 127-130
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł

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