Autor: Schättler, H. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Finite dimensional models of drug resistant and phase specific cancer chemotherapy
Autorzy:: Ledzewicz, U.
Schättler, H.
Świerniak, A.
Powiązania:: https://bibliotekanauki.pl/articles/333055.pdf
Data publikacji:: 2004
Wydawca:: Uniwersytet Śląski. Wydział Informatyki i Nauki o Materiałach. Instytut Informatyki. Zakład Systemów Komputerowych
Tematy:: chemioterapia
odporność na leki
specyfika fazy
bio-modelowanie matematyczne
optymalna kontrola
chemotherapy
drug resistance
phase specificity
biomathematical modelling
optimal control
Opis:: The problem of modelling drug resistance and phase specificity of cancer chemotherapy using finite dimensional models were considered. We formulate optimal control problems arising in protocol design for such models and discuss research issues resulting from these formulations.
Źródło:: Journal of Medical Informatics & Technologies; 2004, 8; IP5-14
1642-6037
Pojawia się w:: Journal of Medical Informatics & Technologies
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Skocz do pozycji: 2.

Tytuł:: Optimal Control for a Class of Compartmental Models in Cancer Chemotherapy
Autorzy:: Świerniak, A.
Ledzewicz, U.
Schättler, H.
Powiązania:: https://bibliotekanauki.pl/articles/908158.pdf
Data publikacji:: 2003
Wydawca:: Uniwersytet Zielonogórski. Oficyna Wydawnicza
Tematy:: medycyna
matematyka
compartmental models
cancer chemotherapy
optimal control
necessary and sufficient conditions for optimality
Opis:: We consider a general class of mathematical models P for cancer chemotherapy described as optimal control problems over a fixed horizon with dynamics given by a bilinear system and an objective which is linear in the control. Several two- and three-compartment models considered earlier fall into this class. While a killing agent which is active during cell division constitutes the only control considered in the two-compartment model, Model A, also two three-compartment models, Models B and C, are analyzed, which consider a blocking agent and a recruiting agent, respectively. In Model B a blocking agent which slows down cell growth during the synthesis allowing in consequence the synchronization of the neoplastic population is added. In Model C the recruitment of dormant cells from the quiescent phase to enable their efficient treatment by a cytotoxic drug is included. In all models the cumulative effect of the killing agent is used to model the negative effect of the treatment on healthy cells. For each model it is shown that singular controls are not optimal. Then sharp necessary and sufficient optimality conditions for bang-bang controls are given for the general class of models P and illustrated with numerical examples.
Źródło:: International Journal of Applied Mathematics and Computer Science; 2003, 13, 3; 357-368
1641-876X
2083-8492
Pojawia się w:: International Journal of Applied Mathematics and Computer Science
Dostawca treści:: Biblioteka Nauki

Artykuł

Zmień widok

na półce

Informacja

Wyszukujesz frazę "Schättler, H." wg kryterium: Autor

Źródło danych

Dostawca treści

Kolekcja

Rok wydania

Wydawca

Temat

Autor

Typ dokumentu

Język