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    Wyświetlanie 1-5 z 5
    Tytuł:
    Occupational allergic and irritant contact dermatitis in workers exposed to polyurethane foam
    Autorzy:
    Kieć-Świerczyńska, Marta
    Świerczyńska-Machura, Dominika
    Chomiczewska-Skóra, Dorota
    Nowakowska-Świrta, Ewa
    Kręcisz, Beata
    Powiązania:
    https://bibliotekanauki.pl/articles/2178820.pdf
    Data publikacji:
    2014-05-17
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    polyurethanes
    isocyanates
    4’-diphenylmethane diisocyanate (MDI)
    diaminodiphenylmethane (MDA)
    occupational contact dermatitis
    Opis:
    Objectives: To evaluate sensitization to chemicals present in work environment after an outbreak of contact dermatitis in workers of vehicle equipment factory, exposed to polyurethane foam, based on 4,4'-diphenylmethane diisocyanate (MDI). Material and Methods: From among 300 employees, 21 individuals reporting work-related skin and/or respiratory tract symptoms underwent clinical examination, patch testing, skin prick tests, spirometry and MDI sIgE measurement in serum. Patch tests included isocyanates series, selected rubber additives, metals, fragrances, preservatives, and an antiadhesive agent. Results: Clinical examination revealed current eczema in the area of hands and/or forearms in 10 workers. Positive patch test reactions were found in 10 individuals, the most frequent to diaminodiphenylmethane and 4-phenylenediamine (7 persons). Reactions to an antiadhesive agent were assessed as irritant (5 workers). Except for sensitization to common aeroallergens, no significant abnormalities were found in the remaining tests. Occupational allergic contact dermatitis was diagnosed in 7 workers, irritant contact dermatitis in 10 and coexisiting allergic and irritant contact dermatitis in 3 workers. Conclusions: In workers manufacturing products from polyurethane foam, attention should be paid to the risk of developing contact dermatitis. Skin problems in our study group were attributable probably to insufficient protection of the skin.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 2; 196-205
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immunological determinants in a murine model of toluene diisocyanate-induced asthma
    Autorzy:
    Świerczyńska-Machura, Dominika
    Walusiak-Skorupa, Jolanta
    Nowakowska-Świrta, Ewa
    Piasecka-Zelga, Joanna
    Świercz, Radosław
    Pałczyński, Cezary
    Powiązania:
    https://bibliotekanauki.pl/articles/2180077.pdf
    Data publikacji:
    2012-09-01
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    toluene diisocyanate
    occupational asthma
    murine model
    allergic infl ammation
    cytokines
    Opis:
    Objectives: Diisocyanates (DIC) are highly reactive, low-molecular-weight chemicals which are the leading cause of occupational asthma (OA). The aim of the study was to analyze certain aspects of the pathogenesis of allergic infl ammation in the airways induced by toluene diisocyanate (TDI) in an experimental model in mice. Materials and Methods: The experiment was carried out on 50 female BALB/cJ/Han/IMP mice, which were exposed by inhalation (intranasal and in the inhalation chamber) to toluene diisocyanate (2,4-TDI). After the experiment, the bronchoalveolar lavage fluid (BALF) was collected from the animals, and the composition of the induced infl ammatory cells, and the concentrations of certain cytokines (IL-4, IL-5, TNF-α) were evaluated. Results: The total number of cells in BALF of the examined group of mice was signifi cantly higher compared to the control mice. There was also a signifi cant increase in neutrophils and eosinophils in the study group compared to the controls. The number of lymphocytes and macrophages did not differ signifi cantly between the two groups. A statistically signifi cant increase in the level of TNF-α was shown to occur in the group exposed to toluene diisocyanate in comparison to the control group. The concentration of IL-4 increased in the study group, compared to the control one, but the differences did not reach the level of signifi cance, p > 0.05. Such difference was not observed for IL-5. Conclusions: We developed a murine model of TDI-induced asthma which caused the infl ux of infl ammatory cells like eosinophils and neutrophils in the bronchoalveolar lavage fl uid (BALF) in the TDI-treated mice. The increase of the concentration of some proinfl ammatory cytokines (TNF-α, IL-4) in BALF from the exposed mice was also observed.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2012, 25, 4; 492-498
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Work-related respiratory symptoms among health centres cleaners: A cross-sectional study
    Autorzy:
    Lipińska-Ojrzanowska, Agnieszka
    Wiszniewska, Marta
    Świerczyńska-Machura, Dominika
    Wittczak, Tomasz
    Nowakowska-Świrta, Ewa
    Pałczyński, Cezary
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2178854.pdf
    Data publikacji:
    2014-06-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    cleaners
    occupational allergy
    work-related respiratory symptoms
    work-related asthma
    WRA
    Opis:
    Objectives: Several studies, mostly based on questionnaire-derived data, have shown an increased risk of allergic diseases, especially asthma, among cleaners. The risk factors and etiological mechanisms are still being investigated. Occupational exposure to various chemical and biological agents may induce specific sensitization and/or irritant effects. The aim of our study was to estimate the prevalence of work-related symptoms suggesting the presence of allergic disease reported by cleaners, and to relate them to the results of commercially available and standardized objective tests used for screening detection of occupational sensitization and chronic respiratory disorders. Material and Methods: A cross-sectional study was performed among 142 Polish workers of cleaning service in their workplaces. A detailed questionnaire, skin prick tests to common allergens and chemicals used by these workers for cleaning purposes (chloramine T, chlorhexidine, formaldehyde, glutaraldehyde, benzalconium chloride), total and specific serum IgE antibodies to disinfectants and rest spirometry were performed in all the subjects. Results: Fifty nine percent of all the subjects declared occurrence of at least 1 symptom suggesting allergic ailment during cleaning activities at work. Skin prick tests and specific serum IgE antibodies to disinfectants were negative in all the subjects. In 8 cases wheezing was detected during auscultation, but only in 5 of them obstructive pattern in rest spirometry was found. Conclusions: Occupational allergic causation of symptoms among cleaners could be less likely than work-related symptoms associated with exacerbations of new-onset or pre-existing respiratory diseases. Therefore, in this group of workers, mainly the non-specific irritant impact of chemicals on airways should be taken into consideration.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2014, 27, 3; 460-466
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sensitization to occupational allergens in hairdressing apprentices diagnosed already before entering vocational training
    Uczulenie na alergeny zawodowe wśród uczniów fryzjerskich przed rozpoczęciem praktycznej nauki zawodu
    Autorzy:
    Golińska-Zach, Aleksandra
    Krawczyk-Szulc, Patrycja
    Wiszniewska, Marta
    Nowakowska-Świrta, Ewa
    Świerczyńska-Machura, Dominika
    Tymoszuk, Diana
    Walusiak-Skorupa, Jolanta
    Powiązania:
    https://bibliotekanauki.pl/articles/2164263.pdf
    Data publikacji:
    2016-09-21
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    szkolenie zawodowe
    fryzjerzy
    narażenie zawodowe
    uczniowie
    alergeny zawodowe
    alergeny fryzjerskie
    vocational training
    hairdressers
    professional exposure
    apprentices
    occupational allergens
    hairdressing allergens
    Opis:
    Background Hairdressers are occupationally exposed to many allergenic and irritating substances. Additionally, hairdressing apprentices are exposed to the same allergens as professional hairdressers, due to the fact that vocational training starts in the beginning of the education. This study was undertaken to investigate early occurrence of sensitization to occupational allergens in hairdressing apprentices before the onset of the vocational training. Material and Methods Three hundred and seven hairdressing apprentices were assessed using a questionnaire and skin prick tests (SPTs) to common and occupational allergens. The level of total and serum specific immunoglobulin E (IgE) to occupational allergens was evaluated and spirometry was performed. Results At least one skin and/or respiratory and/or conjunctival symptom was reported by 29.9% of subjects. Among subjects with at least one symptom, 28.2% of them were atopic whereas among 43.4% of them total IgE level was elevated. Atopy was found in 20% cases. In the case of one apprentice, positive SPT for paraphenylenediamine was found. Nearly 33% of apprentices had elevated total IgE level and 5 of them had specific IgE for occupational allergens. Conclusions The study revealed that hairdressing apprentices might be sensitized to occupational allergens even before the beginning of vocational training, due to prior non-professional exposure to hairdressing agents. Furthermore, many of them report skin, respiratory and conjunctival symptoms, often connected with chronic disease diagnosis. Thus, candidates for hairdressers should be examined thoroughly before the start of the education and tests for allergy to hairdressing substances are indicated. Med Pr 2016;67(5):567–575
    Wstęp Praca w zawodzie fryzjera związana jest z narażeniem na wiele substancji o działaniu alergizującym i drażniącym. Uczniowie fryzjerscy są narażeni na te same alergeny co fryzjerzy profesjonalni, ponieważ praktyczna nauka zawodu zaczyna się na początku nauki w szkole zawodowej. Celem badania było wykrycie uczulenia na alergeny zawodowe u uczniów fryzjerskich obecnego u nich przed rozpoczęciem praktyk zawodowych. Materiał i metody U 307 uczniów fryzjerskich przeprowadzono badania kwestionariuszowe i spirometryczne, punktowe testy skórne (PTS) z pospolitymi aeroalergenami i alergenami zawodowymi. Oznaczono też poziom całkowitej immunoglobuliny E (IgE) i swoistych IgE dla alergenów zawodowych w surowicy krwi. Wyniki Występowanie przynajmniej jednego objawu ze strony skóry i/lub układu oddechowego, i/lub spojówek zgłosiło 29,9% badanych. Wśród 28,2% z nich stwierdzono atopię, a u 43,4% podwyższony poziom całkowitej IgE. W całej grupie badanej atopia występowała u 20% uczniów, a podwyższony poziom całkowitej IgE u 32,8%. U 1 osoby stwierdzono dodatnie wyniki PTS dla parafenylenodiaminy, a u 5 osób obecność swoistych IgE dla fryzjerskich alergenów zawodowych. Wnioski Badanie wykazało, że uczniowie fryzjerscy mogą być uczuleni na alergeny zawodowe już przed rozpoczęciem praktycznej nauki zawodu, co jest związane z dużą pozazawodową ekspozycją na alergeny fryzjerskie. Ponadto wielu z nich jeszcze przed ekspozycją zawodową zgłasza dolegliwości ze strony skóry, układu oddechowego i spojówek, co jednak często wynika z wcześniej rozpoznanych chorób przewlekłych. Z tego powodu ważne jest przeprowadzanie wnikliwych badań, w tym testów alergologicznych, wśród kandydatów do szkół fryzjerskich przed rozpoczęciem przez nich nauki. Med. Pr. 2016;67(5):567–575
    Źródło:
    Medycyna Pracy; 2016, 67, 5; 567-575
    0465-5893
    2353-1339
    Pojawia się w:
    Medycyna Pracy
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Occupational exposure to diisocyanates in polyurethane foam factory workers
    Autorzy:
    Świerczyńska-Machura, Dominika
    Brzeźnicki, Sławomir
    Nowakowska-Świrta, Ewa
    Walusiak-Skorupa, Jolanta
    Wittczak, Tomasz
    Dudek, Wojciech
    Bonczarowska, Marzena
    Wesolowski, Wiktor
    Czerczak, Sławomir
    Pałczyński, Cezary
    Powiązania:
    https://bibliotekanauki.pl/articles/2177097.pdf
    Data publikacji:
    2015-08-10
    Wydawca:
    Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
    Tematy:
    biomarkers
    diisocyanates
    asthma
    polyurethanes
    biological monitoring
    occupational exposure
    occupational diseases
    Opis:
    Objectives The aim of the study was to evaluate health effects of occupational exposure to diisocyanates (DIC) among polyurethane foam products factory workers. Material and Methods Thirty workers had a physical examination, skin prick tests with common allergens, allergen-specific immunoglobulin E (IgE) antibodies to diisocyanates and pulmonary function tests. Concentrations of selected isocyanates in the workplace air samples as well as concentration of their metabolites in the urine samples collected from the workers of the plant were determined. Results The most frequent work-related symptoms reported by the examined subjects were rhinitis and skin symptoms. Sensitization to at least 1 common allergen was noted in 26.7% of the subjects. Spirometry changes of bronchial obstruction of a mild degree was observed in 5 workers. The specific IgE antibodies to toluene diisocyanate (TDI) and 4,4’-methylenebis(phenyl isocyanate) (MDI) were not detected in any of the patients’ serum. Cellular profiles of the collected induced sputum (ISP) did not reveal any abnormalities. Air concentrations of TDI isomers ranged 0.2–58.9 μg/m³ and in 7 cases they exceeded the Combined Exposure Index (CEI) value for those compounds. Concentrations of TDI metabolites in post-shift urine samples were significantly higher than in the case of pre-shift urine samples and in 6 cases they exceeded the British Biological Monitoring Guidance Value (BMGV – 1 μmol amine/mol creatinine). We didn’t find a correlation between urinary concentrations of TDI, concentrations in the air and concentrations of toluenediamine (TDA) in the post shift urine samples. Lack of such a correlation may be an effect of the respiratory protective equipment use. Conclusions Determination of specific IgE in serum is not sensitive enough to serve as a biomarker. Estimation of concentrations of diisocyanate metabolites in urine samples and the presence of work-related allergic symptoms seem to be an adequate method for occupational exposure monitoring of DIC, which may help to determine workers at risk as well as to recognize hazardous workplaces.
    Źródło:
    International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 985-998
    1232-1087
    1896-494X
    Pojawia się w:
    International Journal of Occupational Medicine and Environmental Health
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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