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Wyświetlanie 1-15 z 16
Tytuł:
Relation between expression of TNF alpha, iNOS, VEGF mRNA and development of heart failure after experimental myocardial infarction in rats
Autorzy:
Heba, G.
Krzeminski, T.
Porc, M.
Grzyb, J.
Dembinska-Kiec, A.
Powiązania:
https://bibliotekanauki.pl/articles/69900.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
nitric oxide synthase
tumour necrosis factor-alpha
cytokine
ischaemic myocardium
mRNA
thoracotomy
growth factor
rat
myocardial infarction
vascular endothelial growth factor
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 1
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of serum and tissue magnesium, Vascular Endothelial Growth Factor and osteopontin levels in dogs with mammary tumor with/without pulmonary metastases and in healthy dogs
Autorzy:
Gunay Ucmak, Z.
Koenhemsi, L.
Ucmak, M.
Yalcin, E.
Gonul, R.
Ates, A.
Powiązania:
https://bibliotekanauki.pl/articles/1192810.pdf
Data publikacji:
2021
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
canine mammary tumor
magnesium
osteopontin
vascular endothelial growth factor
Opis:
Mammary tumors in female dogs are usually malignant and tend to metastasize to distant organs, especially to regional lymph nodes and lungs. Radiography is the standard diagnostic method to detect pulmonary metastases in these animals. Magnesium (Mg), vascular endothelial growth factor (VEGF), and osteopontin (OPN) levels have been used in recent studies to make prognoses of human breast cancer. To the best of our knowledge, however, there are not many studies that have been performed on this subject, and there is no study on animals in which the three indicators are scrutinized together. The aim of this present study is to evaluate Mg, VEGF, and OPN levels in healthy dogs and in dogs with mammary tumors with/without pulmonary metastases, and to investigate the alterations of these parameters in the serum and tissue samples of dogs with mammary tumors in connection with the histological tumor type and tumor grade. Mammary tumor groups were designed according to the presence of pulmonary metastasis in radiography; group M1 consists of 20 dogs with metastatic mammary tumors to the lung, and group M0 consists of 20 dogs with nonmetastatic mammary tumors. Ten clinically healthy dogs composed group H. The dogs represented different breeds and ages. Threeview thoracic radiographs were taken to determine any metastasis in lungs by digital radiography. Magnesium, VEGF, and OPN were determined in the mammary gland samples and blood serum of 40 dogs with malignant mammary tumors and in 10 healthy dogs. The magnesium levels were measured by atomic absorption spectrophotometry, both in the tissue and serum samples. Also, the tissue and serum VEGF and OPN levels were determined by ELISA with commercially available kits. The tissue Mg levels in the M0 group were significantly (P<0.05) higher than in group H. However, the serum VEGF level was significantly associated with a tumor type. Additionally, the serum OPN levels exhibited a tendency to be higher in dogs with mammary tumors with pulmonary metastases, grade 3, and carcinosarcoma. It is concluded that Mg, VEGF, and OPN could have practical use for diagnosing and understanding the pathophysiology of CMT.
Źródło:
Journal of Elementology; 2021, 26, 1; 125-135
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vascular Endothelial Growth Factor and Survivin Immunostaining in Gastric Adenocarcinoma
Autorzy:
Bury, Jarosław
Szumiło, Justyna
Dąbrowski, Andrzej
Ciechański, Aleksander
Śliwińska, Justyna
Wallner, Grzegorz
Powiązania:
https://bibliotekanauki.pl/articles/1396680.pdf
Data publikacji:
2012-07-01
Wydawca:
Index Copernicus International
Tematy:
vascular endothelial growth factor
VEGF
survivin
adenocarcinoma
stomach
survival
Opis:
Two molecules - vascular endothelial growth factor involved in new vessels formation and survivin - antiapoptotic protein, reported to be associated with worse prognosis in various malignancies have been chosen for the study. Both are potential target for novel therapiesThe aim of the study was to determine the immunostaining of VEGF and survivin in gastric carcinoma and to analyse their relationship to the selected clinicopathological features and survival.Material and methods. Formalin-fixed, paraffin-embedded sections from 41 gastric adenocarcinomas were used for immunohistochemical reaction with monoclonal antibodies against vascular endothelial growth factor and survivin. The results were compared with selected clinicopathological features and survival.Results. Positive immunohistochemical reaction for vascular endothelial growth factor and survivin was revealed in 24 (58,53%) and 30 (73,17%), gastric carcinomas respectively. Vascular endothelial growth factor-negative gastric carcinomas were significantly more common in cases without metastases to regional lymph nodes and distant organs and in less advanced cases. Similar, distant metastases were also statistically less common in survivin-negative carcinomas. The differences in immunohistochemical reactions for survivin between less and more advanced cases almost reach statistical significance. The only factors significantly influenced 1, 2 and 3-year survival were vascular endothelial growth factor and survivin status. Statistically significant higher percentage of survival was noted in patients with vascular endothelial growth factor- and survivin-negative tumors.Conclusions. It seems that vascular endothelial growth factor and survivin play role in local invasion and spread of gastric adenocarcinoma and negatively influences survival. However, further studies are required to assess their true usefulness in the clinical practice.
Źródło:
Polish Journal of Surgery; 2012, 84, 7; 341-347
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of undecanones and their derivatives on tumor angiogenesis and VEGF content
Autorzy:
Gibka, J
Wasiutynski, A.
Skopinska-Rozewska, E.
Siwicki, A.K.
Chorostowska-Wynimko, J.
Sommer, E.
Mazurkiewicz, M.
Glinski, M.
Skurzak, H.
Wojcik, R.
Jung, L.
Powiązania:
https://bibliotekanauki.pl/articles/31734.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
mice
mouse
undecan-x-one
derivative
angiogenesis
tumour
VEGF zob.vascular endothelial growth factor
enantiomer
histological examination
vascular endothelial growth factor
sarcoma cell
Opis:
The in vivo effects of some derivatives of aliphatic ketones (2-undecanone, 3-undecanone, 4-undecanone and their derivatives) on L-l sarcoma tumor angiogenesis and VEGF content were studied in Balb/c mice. Mice that inhaled 10% solution of 3-undecanone(3-on) or 1% solution of 2-undecanone propylene acetal (Acpr2) for 3 days after tumor cells implantation, presented lower neovascular response measured by tumor-induced cutaneous angiogenesis test (TIA) and lower tumor VEGF content in 5-days tumors, than non-inhaled controls. Other substances presented various effects on tumor VEGF concentration and angiogenesis. Histological examination of lesions collected from mice inhaled Acpr2, or non-inhaled controls, revealed small diffused areas of necrosis in the former group. In both groups, slight to moderate inflammatory infiltrations were seen at the tumor's margin. In Acpr2 group, there were less small blood vessels at tumor's margin than in the control group.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 1; 105-115
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Carbon monoxide - a "new" gaseous modulator of gene expression.
Autorzy:
Dulak, Józef
Józkowicz, Alicja
Powiązania:
https://bibliotekanauki.pl/articles/1043644.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
atherosclerosis
nitric oxide
oxidative stress
Opis:
Carbon monoxide (CO) is an odorless, tasteless and colorless gas which is generated by heme oxygenase enzymes (HOs). HOs degrade heme releasing equimolar amounts of CO, iron and biliverdin, which is subsequently reduced to bilirubin. CO shares many properties with nitric oxide (NO), an established cellular messenger. Both CO and NO are involved in neural transmission and modulation of blood vessel function, including their relaxation and inhibition of platelet aggregation. CO, like NO, binds to heme proteins, although CO binds only ferrous (FeII) heme, whereas NO binds both ferrous and ferric (FeIII). CO enhances the activity of guanylate cyclase although it is less potent than NO. In contrast, CO inhibits other heme proteins, such as catalase or cytochrome P450. The effects of CO on gene expression can be thus varied, depending on the cellular microenvironment and the metabolic pathway being influenced. In this review the regulation of gene expression by HO/CO in the cardiovascular system is discussed. Recent data, derived also from our studies, indicate that HO/CO are significant modulators of inflammatory reactions, influencing the underlying processes such as cell proliferation and production of cytokines and growth factors.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 31-47
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Expression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parameters
Autorzy:
Panigrahi, Ranjita
Jha, Narendra Kumar
Hota, Subhransu Kumar
Powiązania:
https://bibliotekanauki.pl/articles/38695726.pdf
Data publikacji:
2024-03-30
Wydawca:
Uniwersytet Rzeszowski. Wydawnictwo Uniwersytetu Rzeszowskiego
Tematy:
microvessel density
oral squamous cell carcinoma
vascular endothelial growth factor
Opis:
Introduction and aim. Angiogenesis, which is accomplished by capillary sprouting, is the process by which new vessels are created from pre-existing ones. In tumor, once their initial blood supply is depleted, a tumour is unable to grow without additional blood flow. Additionally, a tumor’s microvasculature, or microvessel density (MVD), increases along with its capacity to produce angiogenesis. We aimed to observe the relationship between the expression of vascular endothelial growth factor (VEGF) and MVD (using CD34) in oral squamous cell carcinoma (OSCC). Material and methods. The expression of VEGF and CD34 antibodies was analysed using immunohistochemistry method on 50 cases of histopathologically proved OSCC. The expression was correlated with clinicopathological parameters. Results. A significant correlation was observed between VEGF expression and gender, LVSI. No correlation between any other factors and the difference in VEGF expression was statistically significant. Similarly, the MVD expression was not found to be statistically significant in any of the pathological parameters. Conclusion. VEGF positivity as well as MVD were found to be independent of the tumor pathology. Tumor MVD was found to be independent of the expression of VEGF. Further studies in a larger study group may establish a significant association so that antiangiogenic targeted therapy may be initiated.
Źródło:
European Journal of Clinical and Experimental Medicine; 2024, 22, 1; 82-87
2544-2406
2544-1361
Pojawia się w:
European Journal of Clinical and Experimental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages.
Autorzy:
Józkowicz, Alicja
Dulak, Józef
Powiązania:
https://bibliotekanauki.pl/articles/1043649.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
cell viability
metalloporphyrins
vascular endothelial growth factor
nitric oxide
heme oxygenase
Opis:
Heme oxygenase-1 (HO-1), an inducible enzyme degrading heme to biliverdin, iron and carbon monoxide, is involved in regulation of inflammation and angiogenesis. Tin protoporphyrin (SnPPIX) and zinc protoporphyrin (ZnPPIX) are commonly used as competitive inhibitors of HO-1. We aimed to compare the effects of SnPPIX and ZnPPIX on the production of vascular endothelial growth factor (VEGF), activity of inducible nitric oxide synthase (iNOS) and cell viability. All experiments were performed on rat vascular smooth muscle cells and murine RAW264.7 macrophages treated with 3-10 μM protoporphyrins. Some cells were additionally stimulated with IL-1β or with lipopolysaccharide. After a 24 h incubation period SnPPIX and ZnPPIX significantly reduced the generation of VEGF in vascular smooth muscle cells and RAW264.7, both in resting and stimulated cells. The inhibitory potentials of both protoporphyrins on VEGF synthesis were very similar. In contrast, analysis of iNOS activity revealed that results obtained with different HO-1 inhibitors are discrepant. Generation of nitric oxide by iNOS was significantly increased by SnPPIX but strongly decreased by ZnPPIX. Similar differences were observed when cell viability was compared. SnPPIX improved the cell survival rate, whereas the same doses of ZnPPIX exerted some cytotoxic effects. In summary, SnPPIX and ZnPPIX can be used as HO-1 inhibitors in some experimental models. However, these compounds produce also HO-independent effects, which can make the interpretation of experiments very uncertain. Thus the involvement of the HO-1 pathway should be always confirmed by more specific methods.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 69-79
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Cardiovascular complications of selected antibodies used in oncological immunotherapy
Autorzy:
Kufel-Grabowska, Joanna
Powiązania:
https://bibliotekanauki.pl/articles/1062897.pdf
Data publikacji:
2017
Wydawca:
Medical Education
Tematy:
bevacizumab
immunotherapy
monoclonal antibodies
pertuzumab
trastuzumab
trastuzumab-emtansine
vascular endothelial growth factor
Opis:
Immunotherapy supports other therapeutic methods and is an important element in the fight against cancer. Its main tasks include stimulation and guidance of the immune system to fight cancer, inhibition of the mechanisms that block the immune system, and direct destruction of neoplastic cells. Different from chemotherapy or hormonal therapy, its mechanism of action is associated with a different profile of adverse events. HER2 receptor inhibitors may cause symptoms of heart failure, which usually recede, once the treatment has been discontinued. Bevacizumab, an anti-VEGF antibody, induces numerous cardiovascular complications, including arterial hypertension, arterial embolism, haemorrhage and haemoptysis as well as venous thromboembolism.
Źródło:
OncoReview; 2017, 7, 2; 78-82
2450-6125
Pojawia się w:
OncoReview
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.
Autorzy:
Kimura, Hideo
Esumi, Hiroyasu
Powiązania:
https://bibliotekanauki.pl/articles/1043646.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
vascular endothelial growth factor
hypoxia inducible factor 1
hypoxia
reciprocal regulation
nitric oxide
Opis:
Physiologically, angiogenesis is tightly regulated, or otherwise it leads to pathological processes, such as tumors, inflammatory diseases, gynecological diseases and diabetic retinopathy. The vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis. The VEGF gene expression is regulated by a variety of stimuli. Hypoxia is one of the most potent inducers of the VEGF expression. The hypoxia inducible factor 1 (HIF-1) plays as a key transcription factor in hypoxia-mediated VEGF gene upregulation. Nitric oxide (NO) as well as hypoxia is reported to upregulate the VEGF gene by enhancing HIF-1 activity. The Akt/protein kinase B (PKB) pathway may be involved in NO-mediated HIF-1 activation in limited cell lines. There are some reports of negative effects of NO on HIF-1 and VEGF activity. These conflicting data of NO effects may be attributed mainly to the amount of released NO. Indeed, NO can be a positive or negative modulator of the VEGF gene under the same conditions simply by changing its amounts. The VEGF-mediated angiogenesis requires NO production from activated endothelial NO synthase (eNOS). Activation of eNOS by VEGF involves several pathways including Akt/PKB, Ca2+/calmodulin, and protein kinase C. The NO-mediated VEGF expression can be regulated by HIF-1 and heme oxygenase 1 (HO-1) activity, and the VEGF-mediated NO production by eNOS can be also modulated by HIF-1 and HO-1 activity, depending upon the amount of produced NO. These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues.
Źródło:
Acta Biochimica Polonica; 2003, 50, 1; 49-59
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of integrins and vascular endothelial growth factor isoforms mRNA expression in the canine uterus during perimplantation period
Autorzy:
Bukowska, D.
Kempisty, B.
Jackowska, M.
Wozna, M.
Antosik, P.
Piotrowska, H.
Jaskowski, J.M.
Powiązania:
https://bibliotekanauki.pl/articles/31799.pdf
Data publikacji:
2011
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
integrin
vascular endothelial growth factor
isoform
mRNA expression
dog
uterus
pregnancy
bitch
Opis:
Integrins are the major receptors within the extracellular matrix (ECM) that mediate several functions connected with cell life and metabolism, such as cell adhesion, migration, cytoskeletal organization, proliferation, survival, and differentiation. A vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. It has been suggested that the expression of this gene may play crucial physiological roles in reproductive organs. All investigated endometrial tissues were isolated on day 10-12 after mating. Control bitches, used in this study, were in metestrus, which was determined according to the vaginal cytology and progesterone level in blood. Early pregnancy was verified by flushing the uterine horns with PBS. Total RNA was isolated from the bitches endometrium by means of the Chomczyński and Sacchi method, treated by DNase I, and reverse-transcribed into cDNA. A quantitative analysis of integrins α2b, β2 and β3, VEGF 164, 182 and 188 cDNA was performed by RT-PCR. In results we have shown an increased expression of all investigated genes (integrins α2b, β2 and β3, VEGF 164, 182, and 188) in pregnant bitches uterus as compared to non-pregnant females (P<0.001). Our results indicated that the expression of genes encoding integrins and vascular endothelial growth factors is different in relation to the time of the embryo implantation and it is increased in the first period of this process. This may be associated with the induction of specific mechanisms responsible for receptivity of uterus following the embryo attachment. In addition, all of investigated genes are up-regulated in a pregnancy-specific manner and the increased expression of these genes may regulate the uterus function during the implantation of canine embryos.
Źródło:
Polish Journal of Veterinary Sciences; 2011, 14, 2
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Ligands of peroxisome proliferator-activated receptor-γ increase the generation of vascular endothelial growth factor in vascular smooth muscle cells and in macrophages.
Autorzy:
Jozkowicz, Alicja
Dulak, Jozef
Piatkowska, Ewa
Placha, Wojciech
Dembinska-Kiec, Aldona
Powiązania:
https://bibliotekanauki.pl/articles/1044268.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
angiogenesis
ciglitazone
vascular endothelial growth factor
thiazolidinediones
prostaglandin-J2
peroxisome proliferator-activated receptor-γ
Opis:
Peroxisome proliferator-activated receptors-γ (PPARγ) are ligand-inducible transcription factors of the nuclear hormone receptor superfamily. We examined the effect of PPARγ activation on the generation of vascular endothelial growth factor (VEGF), one of the major angiogenic agents. Rat vascular smooth muscle cells (VSMC) and murine macrophages RAW264.7 were incubated for 24 h with PPARγ activators: prostaglandin J2 and ciglitazone. PPARγ were expressed in VSMC and RAW cells and their activity was upregulated in the presence of PGJ2 and ciglitazone. Incubation of the cells with PPARγ activators significantly augmented the release of VEGF protein into the media, both in resting and in IL-1β- or LPS-stimulated cultures. The higher protein generation was connected with the increased expression of mRNA and transcriptional activation of VEGF promoter. We conclude that the activation of PPARγ upregulates the generation of VEGF and may be involved in the regulation of angiogenesis.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 1147-1157
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Clinical usefulness of assessing VEGF and soluble receptors sVEGFR-1 and sVEGFR-2 in women with breast cancer
Autorzy:
Thielemann, A.
Baszczuk, A.
Kopczynski, Z.
Kopczynski, P.
Grodecka-Gazdecka, S.
Powiązania:
https://bibliotekanauki.pl/articles/50027.pdf
Data publikacji:
2013
Wydawca:
Instytut Medycyny Wsi
Tematy:
clinical usefulness
vascular endothelial growth factor
soluble receptor
woman
breast cancer
patient
human disease
tumour metastasis
Opis:
Introduction. The biological activity of VEGF depends on the presence of its specific receptors on the endothelial surface: VEGFR-1, VEGFR-2, and on their soluble forms sVEGFR-1 and sVEGFR-2. The binding of the membrane-bound receptors with VEGF affects the permeability, proliferation and migration of vascular endothelial cells. This creates the necessary conditions for the vascularisation of solid tumours and for the spread of remote metastases. The sVEGFR-1 and sVEGFR-2 receptors are believed to be natural inhibitors of VEGF. Objective. To determine the clinical usefulness of VEGF and the sVEGFR-1 and sVEGFR-2 receptors level assay in women with primary breast cancer. The assessment also took into account: patient’s age, stage of the disease, histological grade, status of the axillary lymph nodes and size of the primary tumour. Material and methods. The concentrations of VEGF, sVEGFR-1 and sVEGFR-2 were ascertained in 103 women with primary breast cancer. The concentrations of VEGF in the plasma, and those of the soluble receptors sVEGFR-1 and sVEGFR-2 in the serum, were assessed by ELISA, R&D Systems. Results. The study found significantly raised concentrations of VEGF, sVEGFR-1 and sVEGFR-2 in the serum of women with breast cancer, relative to the values obtained from the control group. It was found that with increasing clinical stages of the disease, the levels of VEGF and concentrations of sVEGFR-1 and sVEGFR-2 also increased. Similar findings were noted when assessing the degree of the histological grade of the tumours. Significantly higher values of VEGF protein and the assessed receptors were obtained from women with metastases to the axillary lymph nodes. A positive relationship, though without statistical significance, was noted between the concentration of sVEGFR-2 and the size of the tumour. Conclusions. The high concentrations of the VEGF cytokine and the sVEGFR-1 and sVEGFR-2 receptors in women with breast cancer are responsible for giving rise to the processes of tumour angiogenesis. The concentrations of the VEGF protein and the soluble forms of the receptors sVEGFR-1 and sVEGFR-2 in the serum of breast cancer patients showed positive correlations with the clinical stage of the disease. These results point to the usefulness of VEGF assessment and its soluble receptors in the clinical evaluation of patients with breast cancer.
Źródło:
Annals of Agricultural and Environmental Medicine; 2013, 20, 2
1232-1966
Pojawia się w:
Annals of Agricultural and Environmental Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ 8-miesięcznego treningu sportowego na stężenie naczyniowo-śródbłonkowego czynnika wzrostu u młodych lekkoatletów – udział adaptacyjnej angiogenezy w kształtowaniu wydolności tlenowej
The effects of an 8-month sports training on the levels of vascular endothelial growth factor in young athletes – the role of adaptive angiogenesis in the development of the aerobic capacity
Autorzy:
Krenc, Zbigniew
Mazurowski, Wojciech
Wosik-Erenbek, Marzenna
Wiszniewska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1033854.pdf
Data publikacji:
2015
Wydawca:
Medical Communications
Tematy:
angiogenesis
angiogeneza
athletes
physical efficiency
vascular endothelial growth factor
naczyniowo-śródbłonkowy czynnik wzrostu
wydolność fizyczna
sportowcy
Opis:
A long-term sports training induces morphological and functional changes in the cardiovascular system, with the activation of angiogenesis being one of the most significant ones. Aim: The aim of the study was to assess the impact of an 8-month sports training on the serum levels of vascular endothelial growth factor and the physical performance in young athletes. Material and methods: A total of 28 sports middle school students (athletics faculty) aged 13 years, including 14 boys and 14 girls, were included in the study. All participants underwent clinical assessment at each stage of the study. Electrocardiographic and echocardiographic examinations were performed. Furthermore, the levels of vascular endothelial growth factor were measured and a cardiac stress test was performed, the outcome of which was used to calculate the physical working capacity (PWC170). Results: There was a statistically significant decrease (274.3 ± 195.7 vs. 193.8 ± 153.8 ng/ml, p < 0.001) in the serum levels of vascular endothelial growth factor during the 8-month sports training. The levels were significantly lower in male athletes both at baseline (196.2 ± 157.3 vs. 352.4 ± 204.0 ng/ml, p = 0.02), and at the end of the observation period (139.6 ± 110.9 vs. 247.9 ± 174.6 ng/ml, p = 0.003). In the same period, the average PWC170 value increased throughout the study group (108.6 ± 28.1 vs. 119.0 ± 34.1 W, p = 0.02), and sex-related statistically significant changes occurred only on the male group of athletes. No statistically significant correlations were found between the relative changes in the levels of vascular endothelial growth factor and the PWC170 index (Spearman’s rank correlation coefficient – Rs 0.158, p > 0.05). Conclusions: Long-term sports training results in a decrease in the levels of vascular endothelial growth factor. At the same time, physical efficiency improvement is observed, which may suggest the involvement of adaptive, exerciseinduced angiogenesis in the skeletal muscles. However, the observed changes show distinct differences depending on the sex.
Długotrwały trening sportowy prowadzi do morfologicznych i czynnościowych zmian w układzie sercowo-naczyniowym, wśród których ważne miejsce zajmuje aktywacja procesów angiogenezy. Cel pracy: Celem pracy była ocena wpływu 8-miesięcznego treningu sportowego na stężenie naczyniowo-śródbłonkowego czynnika wzrostu w surowicy oraz wydolność fizyczną u młodych lekkoatletów. Materiał i metody: Badaniem objęto 28 uczniów gimnazjum sportowego o profilu lekkoatletycznym w wieku 13 lat, w tym 14 chłopców i 14 dziewcząt. Na każdym etapie badania wszyscy uczestnicy zostali poddani ocenie klinicznej. Wykonano u nich badania elektrokardiograficzne oraz echokardiograficzne. Oznaczono także stężenie naczyniowo-śródbłonkowego czynnika wzrostu oraz przeprowadzono próbę wysiłkową, której wynik posłużył do wyliczenia wskaźnika wydolności tlenowej PWC170. Wyniki badań: Podczas 8-miesięcznego treningu stężenie naczyniowo- -śródbłonkowego czynnika wzrostu w surowicy zmniejszyło się istotnie statystycznie (274,3 ± 195,7 vs 193,8 ± 153,8 ng/ml, p < 0,001). Jego stężenie było też istotnie niższe w grupie sportowców płci męskiej, zarówno na początku (196,2 ± 157,3 vs 352,4 ± 204,0 ng/ml, p = 0,02), jak i na końcu okresu obserwacji (139,6 ± 110,9 vs 247,9 ± 174,6 ng/ml, p = 0,003). W tym samym okresie średnia wartość wskaźnika PWC170 zwiększyła się w całej badanej grupie (108,6 ± 28,1 vs 119,0 ± 34,1 W, p = 0,02), a w odniesieniu do płci zmiany istotne statystycznie wystąpiły tylko u sportowców płci męskiej. Nie stwierdzono istotnych statystycznie korelacji pomiędzy względnymi zmianami stężenia naczyniowo-śródbłonkowego czynnika wzrostu i wartości wskaźnika PWC170 (współczynnik korelacji rang Spearmana – Rs 0,158, p > 0,05). Wnioski: Podczas długotrwałego treningu sportowego dochodzi do obniżenia stężenia naczyniowo-śródbłonkowego czynnika wzrostu. Jednocześnie obserwowana poprawa wydolności fizycznej może sugerować, że odbywa się to przy udziale adaptacyjnej, indukowanej wysiłkiem fizycznym angiogenezy w mięśniach szkieletowych. Zmiany te wykazują jednak wyraźne różnice zależne od płci.
Źródło:
Pediatria i Medycyna Rodzinna; 2015, 11, 4; 402-409
1734-1531
2451-0742
Pojawia się w:
Pediatria i Medycyna Rodzinna
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The shRNA-mediated silencing of VEGF-C illustrates its role in proliferation, chemosensitization, tumour colonization, and anchorage independence
Autorzy:
Tambe, P.
Purohit, I.
Suneja, D.
More, S.
Desai, P.
Shrivastava, N.
Powiązania:
https://bibliotekanauki.pl/articles/80325.pdf
Data publikacji:
2015
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
vascular endothelial growth factor
gene expression
endothelial cell
breast cancer
lymphangiogenesis
metastasis
proliferation
chemosensitivity
tumour cell
RNAi
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2015, 96, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Bevacizumab in age-related macular degeneration – comparison of subjective estimation of vision with objective test results
Bevacizumab w zwyrodnieniu plamki związanym z wiekiem – porównanie subiektywnej oceny widzenia z obiektywnymi wynikami badań
Autorzy:
Piotrowska-Gwóźdź, Anna
Piotrowska-Seweryn, Agnieszka
Mazur-Piotrowska, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1037681.pdf
Data publikacji:
2015
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
ge-related macular degeneration
bevacizumab
retina
vascular endothelial growth factor
zwyrodnienie plamki związane z wiekiem
beviacizumab
naczyniowy czynnik wzrostu
Opis:
PURPOSE: Anti-VEGF therapy plays a great role in medicine, especially in opthalmology. The aim of the therapy is to inhibit the VEGF-A factors that are responsible for the angiogenesis in diseases such as the wet form of age-related macular degeneration (AMD). One of the monoclonal anti-VEGF antibodies is bevacizumab (Avastin®; Genentech, Inc., South San Francisco, CA). The aim of the study was to compare the subjective estimation of visual acuity with objective test results in patients undergoing anti-VEGF therapy using Avastin. MATERIALS AND METHODS: The authors report a study of 57 patients (37 females and 20 males) with exudative AMD whose near and distance visual acuity was examined before the first dose of Avastin and 1 month after the third injection. Additionally, an original questionnaire evaluating the subjective state of vision during the activities of daily routine was performed. RESULTS: When examining distance visual acuity, 29 patients made an improvement, deterioration was reported in 5 cases and in 23 cases the results remained unaltered. The results were correlated with the subjective estimation. CONCLUSIONS 1. Avastin stabilizes the degeneration process of AMD in most patients and sometimes improves visual acuity. 2. There is a positive correlation between the objective test results and subjective opinion in patients undergoing anti-VEGF therapy using Avastin.
WSTĘP: Terapia anti-VEGF odgrywa niezwykle istotną rolę w medycynie, zwłaszcza w okulistyce. Polega na hamowaniu czynnika VEGF-A, który jest odpowiedzialny za angiogenezę w takich chorobach, jak wysiękowa postać zwyrodnienia plamki związanego z wiekiem (age-related macular degeneration – AMD). Jednym z przeciwciał monoklonalnych skierowanych przeciwko VEGF jest bevacizumab (Avastin®; Genentech, Inc., South San Francisco, CA). Celem badania jest porównanie subiektywnej oceny widzenia z obiektywnymi wynikami badań u pacjentów poddanych terapii anty-VEGF z zastosowaniem Avastinu. MATERIAŁ I METODY: Badaniem objęto 57 pacjentów (37 kobiet 20 mężczyzn) z wysiękową postacią AMD, u których dokonano oceny ostrości wzorku do bliży i dali przed pierwszą dawką i miesiąc po trzeciej iniekcji doszklistkowej Avastinu. Dodatkowo przeprowadzono autorską ankietą oceniającą widzenie podczas wykonywania czynności życia codziennego. WYNIKI: Analizując wyniki ostrości wzroku dla dali 29 pacjentów wykazało poprawę, 5 pogorszenie widzenia, a w 23 przypadkach ostrość wzroku nie uległa zmianie. Wykazano dodatnią korelację powyższych danych z wynikami subiektywnej oceny. WNIOSKI: 1. Avastin stabilizuje proces chorobowy w wysiękowej postaci AMD, a u niektórych pacjentów obserwowana jest poprawa ostrości widzenia. 2. Istnieje dodatnia korelacja między obiektywnymi wynikami ostrości wzroku a subiektywną oceną widzenia u pacjentów poddanych terapii anty-VEGF z zastosowaniem Avastinu.
Źródło:
Annales Academiae Medicae Silesiensis; 2015, 69; 33-41
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 16

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