- Tytuł:
- Partial deglycosylation of α subunit modifies sturgeon gonadotropin function.
- Autorzy:
-
Zenkeviès, Henriks
Vose, Vija
Vosekalne, Ilze
Bcena, Ausma - Powiązania:
- https://bibliotekanauki.pl/articles/1044331.pdf
- Data publikacji:
- 2000
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
α subunit
CD spectrum
sturgeon GTH
gonadotropic hormone
deglycosylation - Opis:
- Chemical deglycosylation (dg) of sturgeon Acipenser gueldenstaedti Br. (αGTH) resulted in the loss of 83% of its initial carbohydrate content. It altered also recombinant dgαGTH + βGTH dimer molecule, reducing its immunoreactivity by 30%, and fully blocking the hormonal function. CD spectroscopy showed that deglycosylation led to changes in the secondary structure of dgαGTH and in the α-β recombinant. The sugar moiety of sturgeon αGTH is suggested to play an important role in maintaining the biological function of the hormone dimer molecule.
- Źródło:
-
Acta Biochimica Polonica; 2000, 47, 3; 815-819
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł