Temat: single - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Association between a nucleotide polymorphism in the calpain 10 gene and carbohydrate metabolism disturbances in patients with polycystic ovary syndrome
Autorzy:: Szydlarska, Dorota
Machaj, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/552368.pdf
Data publikacji:: 2016
Wydawca:: Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:: diabetes
hyperandrogenism
single nucleotide polymorphism.
Źródło:: Family Medicine & Primary Care Review; 2016, 4; 497-500
1734-3402
Pojawia się w:: Family Medicine & Primary Care Review
Dostawca treści:: Biblioteka Nauki

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Tytuł:: SOCS3 is epigenetically up-regulated in steroid resistant nephrotic children
Autorzy:: Zaorska, Katarzyna
Zawierucha, Piotr
Ostalska-Nowicka, Danuta
Nowicki, Michał
Powiązania:: https://bibliotekanauki.pl/articles/1038853.pdf
Data publikacji:: 2016
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: methylation
nephrotic syndrome
single nucleotide polymorphism
steroid resistance
Opis:: Background. The mechanism of steroid resistance in children with the nephrotic syndrome is yet unknown. About 20% of patients demonstrate steroid unresponsiveness and progress to end stage renal disease. Aberrant SOCS3 and SOCS5 expression in steroid resistant and sensitive patients has previously been demonstrated. Here, we investigate genetic and epigenetic mechanisms of regulation of SOCS3 and SOCS5 transcription in nephrotic children. Methods. 76 patients with the nephrotic syndrome (40 steroid resistant and 36 steroid sensitive) and 33 matched controls were included in this study. We performed genotyping of a total of 34 single nucleotide polymorphisms for SOCS3 and SOCS5 promoters and evaluated their methylation status using MS-PCR and QMSP methods. Results. Steroid resistant patients had a significantly lower methylation of one region of SOCS3 promoter in comparison with steroid sensitive patients and controls (p < 0.0001). However, the relative methylation level in the steroid sensitive patients and controls differed significantly even before the first steroid dose (p = 0.001758). Other SOCS3 and SOCS5 promoter regions displayed no differences in methylation or were fully methylated/unmethylated in all study groups, showing site-specific methylation. The allele and genotype distribution for SOCS3 and SOCS5 markers did not differ statistically between the groups. Conclusions. We demonstrate an epigenetic mechanism of SOCS3 up-regulation in steroid resistant children with the nephrotic syndrome. The assessment of methylation/unmethylation of SOCS3 promoter might be an early marker for steroid responsiveness in NS patients.
Źródło:: Acta Biochimica Polonica; 2016, 63, 1; 131-138
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Tytuł:: The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease
Autorzy:: Walczak, Anna
Przybyłowska, Karolina
Sygut, Andrzej
Dziki, Łukasz
Chojnacki, Cezary
Chojnacki, Jan
Dziki, Adam
Majsterek, Ireneusz
Powiązania:: https://bibliotekanauki.pl/articles/1394594.pdf
Data publikacji:: 2012
Wydawca:: Index Copernicus International
Tematy:: single nucleotide polymorphism
MCP-1 gene
inflammatory bowel disease
Opis:: Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn’s disease) as well as 210 healthy controls. Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn’s disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.
Źródło:: Polish Journal of Surgery; 2012, 84, 5; 238-241
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Matrix metalloproteinase-2 C-1306T promoter polymorphism and breast cancer risk in the Saudi population
Autorzy:: Saeed, Hesham
Alanazi, Mohammad
Alshahrani, Omair
Parine, Narasimha
Alabdulkarim, Huda
Shalaby, Manal
Powiązania:: https://bibliotekanauki.pl/articles/1039541.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: breast cancer
matrix metalloproteinases
single nucleotide polymorphism
TaqMan Allele Discrimination assay
Opis:: Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity against matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism (SNP) at -1306, which disrupts a Sp1-type promoter site (CCACC box), displayed a strikingly lower promoter activity with the T allele. In the present study, we investigate whether this MMP-2 SNP is associated with susceptibility to breast cancer in the Saudi population. Ninety breast cancer patients and 92 age matched controls were included in this study. TaqMan Allele Discrimination assay and DNA sequencing techniques were used for genotyping. The results showed that, the frequency of MMP-2 CC wild genotype was lower in breast cancer patients when compared with healthy controls (0.65 versus 0.79). The homozygous CC (OR=2, χ2=5.36, p=0.02) and heterozygous CT (OR=1.98, χ2=4.1, p=0.04) showing significantly high risk of breast cancer in the investigated group. In conclusion our data suggest that the MMP-2 C-1306T polymorphism may be associated with increased breast cancer risk in the Saudi population.
Źródło:: Acta Biochimica Polonica; 2013, 60, 3; 405-409
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Preliminary study to explore gene-$\text{PM}_\text{2.5}$ interactive effects on respiratory system in traffic policemen
Autorzy:: Zhao, Jinzhuo
Bo, Liang
Gong, Changyi
Cheng, Peng
Kan, Haidong
Xie, Yuquan
Song, Weimin
Powiązania:: https://bibliotekanauki.pl/articles/2177102.pdf
Data publikacji:: 2015-08-07
Wydawca:: Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:: inflammation
Fine Particles
traffic workers
respiratory system
single nucleotide polymorphism
SNP
Opis:: Objectives Traffic-related particulate matter (PM) is one of the major sources of air pollution in metropolitan areas. This study is to observe the interactive effects of gene and fine particles (particles smaller than 2.5 μm – $\text{PM}_\text{2.5}$) on the respiratory system and explore the mechanisms linking $\text{PM}_\text{2.5}$ and pulmonary injury. Material and Methods The participants include 110 traffic policemen and 101 common populations in Shanghai, China. Continuous 24 h individual-level $\text{PM}_\text{2.5}$ is detected and the pulmonary function, high-sensitivity C-reactive protein (hs-CRP), Clara cell protein 16 (CC16) and the polymorphism in CXCL3, NME7 and C5 genes are determined. The multiple linear regression method is used to analyze the association between $\text{PM}_\text{2.5}$ and health effects. Meanwhile, the interactive effects of gene and $\text{PM}_\text{2.5}$ on lung function are analyzed. Results The individual $\text{PM}_\text{2.5}$ exposure for traffic policemen was higher than that in the common population whereas the forced expiratory volume in 1 s (FEV₁), the ratio of FEV₁ to forced vital capacity (FEV₁/FVC) and lymphocytes are lower. In contrast, the hs-CRP level is higher. In the adjusted analysis, $\text{PM}_\text{2.5}$ exposure was associated with the decrease in lymphocytes and the increase in hs-CRP. The allele frequencies for NME7 and C5 have significant differences between FEV₁/FVC ≤ 70% and FEV₁/FVC > 70% participants. The results didn’t find the interaction effects of gene and $\text{PM}_\text{2.5}$ on FEV₁/FVC in all the 3 genes. Conclusions The results indicated that traffic exposure to high levels of $\text{PM}_\text{2.5}$ was associated with systemic inflammatory response and respiratory injury. Traffic policemen represent a high risk group suffering from the respiratory injury.
Źródło:: International Journal of Occupational Medicine and Environmental Health; 2015, 28, 6; 971-983
1232-1087
1896-494X
Pojawia się w:: International Journal of Occupational Medicine and Environmental Health
Dostawca treści:: Biblioteka Nauki

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Tytuł:: Polymorphic variants of MIF gene and prognosis in steroid therapy in children with idiopathic nephrotic syndrome
Autorzy:: Świerczewska, Monika
Ostalska-Nowicka, Danuta
Kempisty, Bartosz
Szczepankiewicz, Aleksandra
Nowicki, Michał
Powiązania:: https://bibliotekanauki.pl/articles/1039333.pdf
Data publikacji:: 2014
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: nephrotic syndrome
steroid resistance
MIF gene
single nucleotide polymorphism
short tandem repeat
Opis:: Nephrotic syndrome (NS) is the most common reason of proteinuria in children and can be caused by the pathology of renal glomeruli. Steroid therapy is typically used in this disorder. It has been shown that MIF is a cytokine which counteracts the immunosuppressive properties of glucocorticoids. The aim of this study was looking for a correlation between MIF polymorphisms and genetic susceptibility to steroid resistance in children with INS (Idiopathic NS). Methods: The study was performed in 71 patients with INS including SRNS (steroid resistance nephrotic syndrome) (41) and SSNS (steroid sensitive nephrotic syndrome) (30) and in 30 control subjects. We employed Sanger sequencing and capillary electrophoresis. Linkage disequilibrium was made using Haploview and PHASE. Results: We didn't observe a statistical significance between SNPs detected in patients with INS and controls. Our studies revealed statistical significance for two polymorphisms: rs2070767C > T and rs2000466T > G between patients with SRNS and SSNS. The results for rs34383331T > A are close to being statistically significant. Statistical significance was revealed for CATT5/CATT6 genotype in SRNS group vs SSNS group (OR=4.604, 95%CI=1.356-15.632, p=0.0168). We found that the frequency of 5/X-CATT genotype compared with X/X-CATT genotype was significantly higher in SRNS patients vs SSNS (OR=3.167, 95%CI=1.046-9.585, p=0.0426). In linkage disequilibrium analysis we didn't show involvement in susceptibility to INS and steroid sensitive phenotype. Conclusions: Our results suggest that the role of MIF polymorphisms in the susceptibility to positive response to steroid therapy is still unresolved. It indicates that MIF may be involved in indirect and complex molecular mechanisms of steroid activity in hormone-dependent metabolic pathways in children with INS. Because of ambiguous findings, pleiotropic features of this cytokine require that more research should be undertaken.
Źródło:: Acta Biochimica Polonica; 2014, 61, 1; 67-75
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: A comprehensive in silico prediction of the most deleterious missense variants in the bovine LEP gene
Autorzy:: Al-Shuhaib, M.B.S.
Powiązania:: https://bibliotekanauki.pl/articles/80824.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: LEP gene
leptin
biological activity
bovine gene
single nucleotide polymorphism
coding sequence
cattle
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 4
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: CTLA-4 polymorphisms (+49 A/G and -318 C/T) are important genetic determinants of AITD susceptibility and predisposition to high levels of thyroid autoantibodies in Polish children - preliminary study
Autorzy:: Pastuszak-Lewandoska, Dorota
Domańska, Daria
Rudzińska, Magdalena
Bossowski, Artur
Kucharska, Anna
Sewerynek, Ewa
Czarnecka, Karolina
Migdalska-Sęk, Monika
Czarnocka, Barbara
Powiązania:: https://bibliotekanauki.pl/articles/1039459.pdf
Data publikacji:: 2013
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: Graves' disease
Hashimoto's thyroiditis
autoimmune thyroid disease
CTLA-4
single nucleotide polymorphism
TAb production
Opis:: Autoimmune thyroid diseases (AITDs), including Hashimoto' s thyroiditis (HT) and Graves' disease (GD), are related to environmental and genetic factors. We analyzed the association of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) gene two polymorphisms (+49 A/G, -318 C/T) with HT and GD development in Polish children, and correlated both polymorphisms with the production of thyroid autoantibodies (TPOAb and TgAb). The study involved 49 AITD patients (age 10-19) with HT (n=25) or GD (n=24) and 69 healthy controls. SNP genotyping was performed using genomic DNA and TaqMan® probes. The obtained results indicated that CTLA-4 +49 GG genotype was significantly more frequent in both HT and GD patients, whereas the AA genotype was more common in controls. CTLA-4-318 CT genotype was significantly more frequent in AITD, and the CC genotype more often occurred in controls. Significantly higher median TPOAb and TgAb values were associated with G allele in HT, and with T allele in GD patients. Concluding, both studied polymorphisms seem to be important genetic determinants of the risk of HT and GD, and appear to be associated with a predisposition to high levels of TAbs and clinical AITD. The obtained results give more information on the distribution of the CTLA-4 polymorphism in Polish AITD children, and further support the proposal that the CTLA-4 gene plays an important role in a TAb production.
Źródło:: Acta Biochimica Polonica; 2013, 60, 4; 641-646
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Joint effect of N-acetyltransferase 2 gene and smoking status on bladder carcinogenesis in Algerian population
Autorzy:: Ribouh-Arras, A.
Chaoui-Kherouatou, N.
Hireche, A.
Abadi, N.
Satta, D.
Powiązania:: https://bibliotekanauki.pl/articles/80202.pdf
Data publikacji:: 2019
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: N-acetyltransferase 2 gene
genetic polymorphism
malignancy
bladder cancer
single nucleotide polymorphism
phenotype
smoking
Algerian population
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2019, 100, 2
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Prediction of indels and SNP’s in coding regions of glutathione peroxidases - an important enzyme in redox homeostasis of plants
Autorzy:: Ganguli, S.
Datta, A.
Powiązania:: https://bibliotekanauki.pl/articles/11303.pdf
Data publikacji:: 2014
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: prediction
indel
single nucleotide polymorphism
coding region
glutathione peroxidase
enzyme
redox
homeostasis
plant
genotype
stress tolerance
Opis:: Plant glutathione peroxidases are an important class of enzymes which play key roles in the stress adaptability of plants both in context of biotic and abiotic stress pathways. They have been over the years much studied in animals since the catalytic residues are comprised of selenocysteine a variant amino acid which is ribosomally encoded with the help of an RNA structural element known as SECIS. Various workers over the years have shown that plant glutathione peroxidases play active roles in ROS sequestration, lipid hydroperoxidation as well as regulate glutathione levels. However, each plant has various patterns of glutathione peroxidase expression and action and in some plants certain isoforms have not been detected at all. This work focuses on the prediction and identification of single nucleotide polymorphisms (SNPs) and INDELs in the coding regions of plant glutathione peroxidases, with the help of a Bayesian based algorithm subsequently validated. A large number of informative sites were detected 279 of which had variant frequency of ≥ 50 %. This data should be beneficial for future studies involving genetic manipulation and population based breeding experiments.
Źródło:: International Letters of Natural Sciences; 2014, 02
2300-9675
Pojawia się w:: International Letters of Natural Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Detection of SNPs based on DNA specific-locus amplified fragment sequencing in Chinese fir (Cunninghamia lanceolata (Lamb.) Hook)
Autorzy:: Su, Y.
Hu, D.
Zheng, H.
Powiązania:: https://bibliotekanauki.pl/articles/41243.pdf
Data publikacji:: 2016
Wydawca:: Polska Akademia Nauk. Instytut Dendrologii PAN
Tematy:: detection
single nucleotide polymorphism
DNA specific-locus amplified fragment sequencing
fir
Chinese fir
Cunninghamia lanceolata
genotyping
Opis:: Compared to angiosperms, conifers represent more complex genomes with larger giga-genome size. To detect large-scale single nucleotide polymorphisms (SNPs), whole genome sequencing of a conifer population is still unaffordable. In this work, we report the use of DNA specific-locus amplified fragment sequencing (SLAF-seq) for large-scale SNP detection in Chinese fir (Cunninghamia lanceolata (Lamb.) Hook), an ecological and economic important conifer in China. SLAF libraries of 18 parent clones of a Chinese fir 2.5 generation seed orchard were sequenced and a total of 117,924 SLAFs were developed. We detected 147,376 SNPs from these SLAFs; 146,231 of them represented simple nucleotide change in A/G, C/T, A/C, A/T, C/G or G/T. The most frequent SNPs occurred in C/T (34.3%), while the majority of SNPs (68.2%) belonged to transition events (A/G and C/T). Notably, all the sequenced samples had high portion (78.2–80.9%) of common SNPs indicating that the Chinese fir genomes tended to change its nucleotides at common loci. 48,406 informative SNPs were then successfully utilized to genotype the tested samples (n = 18) followed by a phylogenetic tree to clarify their genetic relationship. Furthermore, a set of very high linkage disequilibrium (0.51–1.00) were identified from these informative SNPs. In brief, our work demonstrated that SLAF-seq is an alternative and cost-effectively high-throughput approach for large-scale SNP exploitation in Chinese fir. While the obtained SNPs offer useful marker resource for further genetic and genomic studies and will be helpful for Chinese fir breeding programs.
Źródło:: Dendrobiology; 2016, 76
1641-1307
Pojawia się w:: Dendrobiology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: The mRNA sequence polymorphisms of flowering key genes in bolting sensitive or tolerant sugar beet genotypes
Autorzy:: Alimirzaee, M.
Mirzaie-Asl, A.
Abdollahi, M.R.
Kolaei, H.E.
Fasahat, P.
Powiązania:: https://bibliotekanauki.pl/articles/79841.pdf
Data publikacji:: 2017
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: sugar-beet
Beta vulgaris ssp.maritima
mRNA
polymorphism
flowering
single nucleotide polymorphism
genetic control
RNA extraction
protein structure prediction
Źródło:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2017, 98, 3
0860-7796
Pojawia się w:: BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Czy „cichy” polimorfizm pojedynczego nukleotydu (SNP) C1236T genu ABCB1 jest związany z predyspozycją do rozwoju depresji i skutecznością jej leczenia? - badanie wstępne
Is the „silent” single nucleotide polymorphism (SNP) C1236T of ABCB1 gene associated with predisposition to depression development and efficiency of therapy? – preliminary study
Autorzy:: Jeleń, Agnieszka
Koziróg, Anna
Sałagacka, Aleksandra
Balcerczak, Ewa
Talarowska, Monika
Gałecki, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1032546.pdf
Data publikacji:: 2014
Wydawca:: Łódzkie Towarzystwo Naukowe
Tematy:: abcb1
polimorfizm pojedynczego nukleotydu
c1236t
glikoproteina p
depresja
farmakogenomika
podatność
single nucleotide polymorphism
p-glycoprotein
depression
pharmacogenomics
susceptibility
Opis:: Introduction: According to the World Health Organization about 350 million people around the world are affected by depression. Despite the high prevalence of this disease the mechanism of depression origination as well as the causes of the resistance to therapy are still not fully understood. ABCB1 gene encode P glycoprotein which is one of the components of blood-brain barrier. The main function of this protein is the efflux of many toxic compounds, including drugs, which may indicate potential association between the proper functioning of P glycoprotein and the susceptibility to the development of depressive disorders or the failure of antidepressant therapy. The objective of this study was to evaluate single nucleotide polymorphism (SNP) C1236T of the ABCB1 gene in the group of patients with recurrent depressive disorder (rDD) and to estimate the possible association of this polymorphism with the response to antidepressant therapy. Material and methods: C1236T was evaluated in 30 patients with rDD. Genotyping was performed using automated sequencing (the Sanger method). The results were compared with those obtained from the control group which consisted of 96 blood donors from the local blood bank. Results: No statistically significant difference in the frequency of genotypes (p=0.0665) and allele (p=0.1489) for the SNP C1236T of ABCB1 gene was found between the patients with rDD and the control group. No correlation between C1236 and the age when the disease was stated (p=0.0807). Neither the association between genotypes and the severity of depressive symptoms before treatment (p=0.7956) nor the association with effectiveness of the therapy (p=0.2051) were found. Conclusions: On the basis of the results of the preliminary study, C1236T of ABCB1 gene have no influence on the predisposition to rDD, the severity of depressive symptoms and the efficiency of antidepressant therapy have not been stated, either.
Streszczenie Wstęp: Według danych Światowej Organizacji Zdrowia depresja dotyka około 350 milionów osób na całym świecie. Jednak pomimo powszechnego występowania, zarówno etiologia tej choroby, jak i przyczyny oporności na leczenie w dalszym ciągu nie są w pełni poznane. Gen ABCB1 koduje glikoproteinę P, która jest jednym z elementów bariery krew-mózg. Główną funkcją białka jest usuwanie związków toksycznych, w tym także leków, co może wskazywać na potencjalny związek między prawidłowym działaniem glikoproteiny P a predyspozycją do rozwoju zaburzeń depresyjnych czy niepowodzeniem terapii lekami przeciwdepresyjnymi. Celem pracy była ocena polimorfizmu pojedynczego nukleotydu (ang. single nucleotide polymorphism - SNP) C1236T genu ABCB1 wśród chorych na zaburzenia depresyjne nawracające (ang. recurrent depressive disorder - rDD) oraz oszacowanie potencjalnego związku tego polimorfizmu z odpowiedzią na terapię lekami przeciwdepresyjnymi. Materiał i metody: Polimorfizm C1236T oceniono w grupie 30 pacjentów, u których zdiagnozowano rDD. Genotyp określono wykorzystując technikę automatycznego sekwencjonowania metodą Sangera. Otrzymane wyniki porównano z wynikami grupy kontrolnej, którą stanowiło 96 dawców krwi z lokalnego banku krwiodawstwa. Wyniki: Nie stwierdzono istotnych statystycznie różnic w częstości występowania poszczególnych genotypów (p=0,0665) i alleli (p=0,1489) polimorfizmu C1236T genu ABCB1 między grupą pacjentów z rDD a grupą kontrolną. Nie wykazano również zależności pomiędzy C1236T a wiekiem w chwili diagnozy rDD (p=0,0807), nasileniem objawów depresji przed rozpoczęciem terapii (p=0,7956) czy skutecznością leczenia przeciwdepresyjnego (p=0,2051). Wnioski: Na podstawie wyników badania wstępnego, stwierdzono brak wpływu polimorfizmu C1236T genu ABCB1 na predyspozycję do rozwoju rDD, nasilenie objawów depresji w chwili diagnozy czy skuteczność terapii przeciwdepresyjnej.
Źródło:: Folia Medica Lodziensia; 2014, 41, 1; 5-15
0071-6731
Pojawia się w:: Folia Medica Lodziensia
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Różnice genetyczne i psychologiczne w percepcji bólu u zawodników sportów walki
Genetic and psychological differences in pain perception in martial arts athletes
Autorzy:: Leźnicka, K.
Pierzchlińska, A.
Starkowska, A.
Machoy-Mokrzyńska, A.
Białecka, M.
Powiązania:: https://bibliotekanauki.pl/articles/135816.pdf
Data publikacji:: 2017
Wydawca:: Wyższa Szkoła Techniczno-Ekonomiczna w Szczecinie
Tematy:: percepcja bólu
próg bólu
tolerancja na ból
sportowcy
polimorfizm pojedynczego nukleotydu
stres
metody radzenia sobie ze stresem
temperament
pain perception
pain threshold
pain tolerance
athletes
single nucleotide polymorphism
stress coping methods
Opis:: Wstęp i cel: Wielu autorów podkreśla fakt zmniejszonego progu bólowego, a także tolerancji na ból u sportowców. Wciąż jednak nie wiadomo, w jakim stopniu mają w tym udział czynniki genetyczne, a w jakim psychologiczne i psychospołeczne. Celem niniejszej pracy jest przedstawienie możliwych mechanizmów wpływających na różnice w percepcji bólu. Materiał i metody: Na podstawie dostępnego piśmiennictwa autorzy opisali metody pomiaru natężenia bólu oraz przedstawili możliwe źródła różnic w percepcji bólu u zawodników sportów walki w stosunku do osób nieuprawiających zawodowo sportu. Wyniki: Opracowano poszczególne czynniki mogące wpływać na percepcję bólu u sportowców. Wniosek: Mimo braku różnic genetycznych w polimorfizmach pojedynczych nukleotydów genów OPRM1 i COMT, zanotowano istotne różnice w metodach radzenia sobie ze stresem oraz w natężeniu cech temperamentu między zawodnikami sportów walki a grupami kontrolnymi. Prawdopodobne, że cechy temperamentu wpływają na wypracowanie określonych strategii radzenia sobie z bólem.
Introduction and aim: Many authors emphasise lower pain threshold and pain tolerance among athletes. Though, it is not known to what degree genetic, psychological and psychosocial factors are involved. The aim of this paper is to present possible mechanisms affecting the differences in pain perception. Material and methods: On the grounds of the available literature, the authors describe the pain measure methods and present the possible source of the pain perception differences in martial arts athletes compared to non-athletes. Results: Several factors likely to be involved in pain perception among athletes has been elaborated. Conclusion: Although, there have been no differences in single nucleotide polymorphisms in genes OPRM1 and COMT, significant differences in stress coping strategies and temperament traits between martial arts athletes and control groups have been found. Presumably, temperament traits influence the development of particular pain coping strategies.
Źródło:: Problemy Nauk Stosowanych; 2017, 7; 183-190
2300-6110
Pojawia się w:: Problemy Nauk Stosowanych
Dostawca treści:: Biblioteka Nauki