Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "transduction" wg kryterium: Temat

  Lista filtrów
Wyrównaj
Wyświetlanie 1-15 z 28
Tytuł:
Lipids and signal transduction in the nucleus.
Autorzy:
Dygas, Anna
Barańska, Jolanta
Powiązania:
https://bibliotekanauki.pl/articles/1044152.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction
nucleus
Opis:
During the last few years a growing amount of data has accumulated showing phospholipid participation in nuclear signal transduction. Very recent data strongly support the hypothesis that signal transduction in the nucleus is autonomic. Local production of inositol polyphosphates, beginning with the activation of phospholipase C is required for their specific function in the nucleus. Enzymes which modify polyphosphoinositols may control gene expression. Much less information is available about the role of other lipids in nuclear signal transduction. The aim of this minireview is to stress what is currently known about nuclear lipids with respect to nuclear signal transduction.
Źródło:
Acta Biochimica Polonica; 2001, 48, 2; 541-549
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Hydrolysis of cyclic GMP in rat peritoneal macrophages.
Autorzy:
Witwicka, Hanna
Kobiałka, Marcin
Gorczyca, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1043691.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction
phosphodiesterases
cyclic nucleotides
macrophages
Opis:
Intact rat peritoneal macrophages (rPM) treated with 3-isobutyl-1-methylxanthine (IBMX), an inhibitor of phosphodiesterases (PDEs), accumulated more cGMP than untreated cells. A PDE activity toward [3H]cGMP was detected in the soluble and particulate fractions of rPM. The hydrolysis of cGMP was Ca2+/calmodulin-independent but increased in the presence of cGMP excess. Similar results were obtained when [3H]cAMP was used as a substrate. The hydrolytic activity towards both nucleotides was inhibited in the presence of IBMX. Therefore, the PDEs of families 2, 5, 10 and 11 are potential candidates for cGMP hydrolysis in the rPM. They may not only regulate the cGMP level in a feedback-controlled way but also link cGMP-dependent pathways with those regulated by cAMP.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 891-897
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The basic biology of erbB-2 and its participation in colorectal cancers
Autorzy:
Stawińska, Magdalena
Bryś, Magdalena
Krajewska, Wanda M
Powiązania:
https://bibliotekanauki.pl/articles/764806.pdf
Data publikacji:
2005
Wydawca:
Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
Tematy:
ErbB-2
colorectal cancers
signal transduction
tumour growth
Opis:
ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission of signals controlling normal cell growth and differentiation. A range of growth factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers are formed and cell signalling is stronger, resulting in enhanced responsiveness to growth factors and malignant growth. This explains why ErbB-2 overexpression is an indicator of poor prognosis in colorectal cancers and may be predictive of response to treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.
Źródło:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2005, 2
1730-2366
2083-8484
Pojawia się w:
Acta Universitatis Lodziensis. Folia Biologica et Oecologica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Signal transmission via G protein-coupled receptors in the light of rhodopsin structure determination.
Autorzy:
Ciarkowski, Jerzy
Drabik, Piotr
Giełdoń, Artur
Kaźmierkiewicz, Rajmund
Ślusarz, Rafał
Powiązania:
https://bibliotekanauki.pl/articles/1044085.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction
neurohypophyseal receptors
molecular modeling
GPCRs
Opis:
G protein-coupled receptors (GPCRs) transducing diverse external signals to cells via activation of heterotrimeric GTP-binding (G) proteins, estimated to mediate actions of 60% of drugs, had been resistant to structure determination until summer 2000. The first atomic-resolution experimental structure of a GPCR, that of dark (inactive) rhodopsin, thus provides a trustworthy 3D prototype for antagonist-bound forms of this huge family of proteins. In this work, our former theoretical GPCR models are evaluated against the new experimental template. Subsequently, a working hypothesis regarding the signal transduction mechanism by GPCRs is presented.
Źródło:
Acta Biochimica Polonica; 2001, 48, 4; 1203-1207
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells.
Autorzy:
Rattan, Suresh
Gonzalez-Dosal, Regina
Nielsen, Elise
Kraft, David
Weibel, Jens
Kahns, Søren
Powiązania:
https://bibliotekanauki.pl/articles/1043285.pdf
Data publikacji:
2004
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
aging
signal transduction
anti-aging
longevity
proteasome
heat shock
Opis:
Since aging is primarily the result of a failure of maintenance and repair mechanisms, various approaches are being developed in order to stimulate these pathways and modulate the process of aging. One such approach, termed hormesis, involves challenging cells and organisms by mild stress that often results in anti-aging and life prolonging effects. In a series of experimental studies, we have reported that repeated mild heat stress (RMHS) has anti-aging hormetic effects on growth and various cellular and biochemical characteristics of human skin fibroblasts undergoing aging in vitro. These beneficial effects of repeated challenge include the maintenance of stress protein profile, reduction in the accumulation of oxidatively and glycoxidatively damaged proteins, stimulation of the proteasomal activities for the degradation of abnormal proteins, improved cellular resistance to other stresses, and enhanced levels of cellular antioxidant ability. In order to elucidate the molecular mechanisms of hormetic effects of RMHS, we are now undertaking studies on signal transduction pathways, energy production and utilisation kinetics, and the proteomic analysis of patterns of proteins synthesised and their posttranslational modifications in various types of human cells undergoing cellular aging in vitro. Human applications of hormesis include early intervention and modulation of the aging process to prevent or delay the onset of age-related conditions, such as sarcopenia, Alzheimer's disease, Parkinson's disease, cataracts and osteoporosis.
Źródło:
Acta Biochimica Polonica; 2004, 51, 2; 481-492
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Structure and functions of plant calcium-dependent protein kinases
Autorzy:
Klimecka, Maria
Muszyńska, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1041065.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction
stress responses
cross-talk
calcium
plant protein kinases
Opis:
Calcium ions as second messengers play an essential role in many important cellular processes. In plants, transient changes in calcium content in the cytosol (calcium signatures) have been observed during growth, development and under stress conditions. Such diverse functions require many different calcium sensors. One of the largest and most differentiated group of calcium sensors are protein kinases, among them calcium-dependent protein kinases (CDPKs) which were identified only in plants and protists. CDPKs have a regulatory domain which is able to bind calcium ions. For regulation of CDPKs activities not only calcium ions but also specific phospholipids and autophosphorylation are responsible. CDPKs have many different substrates, which reflects the diversity of their functions. Potential protein substrates of CDPK are involved in carbon and nitrogen metabolism, phospholipid synthesis, defense responses, ion and water transport, cytoskeleton organization, transcription and hormone responses. Presently, participation of CDPKs in stress signal transduction pathways (e.g., cold, drought, high salinity, wounding) is intensively studied in many laboratories. An intriguing, but still not fully clarified problem is the cross-talk via CDPKs among different signaling pathways that enables signal integration at different levels and ensure appropriate downstream responses.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 219-233
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular cloning, characterization and expression of a guanylyl cyclase (HpGC1) involved in the stress signalling in Hippeastrum x hybr.
Autorzy:
Swiezawska, B.
Szewczuk, P.
Pawelek, A.
Jaworski, K.
Szmid-Jaworska, A.
Powiązania:
https://bibliotekanauki.pl/articles/81222.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
molecular cloning
expression
characteristics
guanylyl cyclase
signal transduction
light signal transduction
biotic stress
abiotic stress
stress tolerance
Hippeastrum x hybridum
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 3
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Particulate guanylyl cyclases: multiple mechanisms of activation.
Autorzy:
Kobiałka, Marcin
Gorczyca, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1044281.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
signal transduction
calcium-binding proteins
guanylyl cyclases
cyclic nucleotides
Opis:
Cyclic GMP (cGMP), a key messenger in several signal transduction pathways, is synthesized from GTP by a family of enzymes termed guanylyl cyclases, which are found in two forms: cytosolic (soluble) and membrane-bound (particulate). The past decade has brought significant progress in understanding the molecular mechanisms that underlie the regulation of particulate guanylyl cyclases and new members of their family have been identified. It has become more evident that the basic mechanism of catalysis of guanylyl cyclases is analogous to that recognized in adenylyl cyclases. Here we review the known basic mechanisms that contribute to the regulation of particulate guanylyl cyclases.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 517-528
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arabidopsis thaliana MKKK18 is involved in abscisic acid signalling
Autorzy:
Mitula, F.
Tajdel, M.
Sadowski, J.
Ludwikow, A.
Powiązania:
https://bibliotekanauki.pl/articles/81146.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
Arabidopsis thaliana
abscisic acid
MAP kinase inhibitor
signal transduction
gfp gene
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Protein phosphatase 2A: Variety of forms and diversity of functions
Autorzy:
Lechward, Katarzyna
Awotunde, Olubunmi
Świątek, Wojciech
Muszyńska, Grażyna
Powiązania:
https://bibliotekanauki.pl/articles/1044037.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
protein phosphatase 2A
signal transduction
protein-protein interactions
reversible phosphorylation
cell cycle
carcinogenesis.
Opis:
Protein phosphatase 2A (PP2A) comprises a diverse family of phosphoserine-and phosphothreonine-specific phosphatases present in all eukaryotic cells. All forms of PP2A contain a catalytic subunit (PP2Ac) which forms a stable complex with the structural subunit PR65/A. The heterodimer PP2Ac-PR65/A associates with regulatory proteins, termed variable subunits, in order to form trimeric holoenzymes attributed with distinct substrate specificity and targeted to different subcellular compartments. PP2Ac activity can be modulated by reversible phosphorylation on Tyr307 and methylation on C-terminal Leu309. Studies on PP2A have shown that this enzyme may be implicated in the regulation of metabolism, transcription, RNA splicing, translation, differentiation, cell cycle, oncogenic transformation and signal transduction.
Źródło:
Acta Biochimica Polonica; 2001, 48, 4; 921-933
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Environmental factors-induced stomatal signalling
Autorzy:
Merilo, E.
Laanemets, K.
Xue, S.
Margna, L.
Schroeder, J.
Brosche, M.
Kollist, H.
Powiązania:
https://bibliotekanauki.pl/articles/80937.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
environmental factor
stomatal signalling
signal transduction
stomatal conductance
carbon dioxide
air humidity
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Metabolism of cyclic GMP in peritoneal macrophages of rat and guinea pig.
Autorzy:
Kobiałka, Marcin
Witwicka, Hanna
Siednienko, Jakub
Gorczyca, Wojciech
Powiązania:
https://bibliotekanauki.pl/articles/1043463.pdf
Data publikacji:
2003
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
guinea pig
rat
signal transduction
phosphodiesterases
guanylyl cyclases
protein kinases
cyclic nucleotides
macrophages
Opis:
The aim of our studies was to establish which enzymes constitute the "cGMP pathway" in rat and guinea pig peritoneal macrophages (PM). We found that in guinea pig PM synthesis of the nucleotide was significantly enhanced in response to activators of soluble guanylyl cyclase (sGC) and it was only slightly stimulated by specific activators of particulate guanylyl cyclases (pGC). In contrast, rat PM responded strongly to atrial natriuretic peptide (ANP), the activator of pGC type A. The rat cells synthesized about three-fold more cGMP than an equal number of the guinea pig cells. The activity of phosphodiesterases (PDE) hydrolyzing cGMP was apparently regulated by cGMP itself in PM of both species and again it was higher in the rat cells than in those isolated from guinea pig. However, guinea pig PM revealed an activity of Ca2+/calmodulin-dependent PDE1, which was absent in the rat cells. Using Western blotting analysis we were unable to detect the presence of cGMP-dependent protein kinase 1 (PKG1) in PM isolated from either species. In summary, our findings indicate that particulate GC-A is the main active form of GC in the rat PM, while in guinea pig macrophages the sGC activity dominates. Since the profiles of the PDE activities in rat and guinea pig PM are also different, we conclude that the mechanisms regulating cGMP metabolism in PM are species-specific. Moreover, our results suggest that targets for cGMP other than PKG1 should be present in PM of both species.
Źródło:
Acta Biochimica Polonica; 2003, 50, 3; 837-847
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Przeciwciała monoklonalne w regulacji transdukcji sygnału receptora naskórkowego czynnika wzrostu (EGFR) w komórkach nowotworowych
Monoclonal antibodies in regulation of signal transduction of Epidermal Growth Factor Receptor (EGFR) pathway in cancer cells
Autorzy:
Kampa, Rafał Paweł
Sypniewski, Daniel
Bednarek, Ilona
Powiązania:
https://bibliotekanauki.pl/articles/1035845.pdf
Data publikacji:
2018
Wydawca:
Śląski Uniwersytet Medyczny w Katowicach
Tematy:
kancerogeneza
terapia przeciwnowotworowa
transdukcja sygnału
egfr
przeciwciała monoklonalne
carcinogenesis
anticancer therapy
signal transduction
monoclonal antibodies
Opis:
In recent years intensive research has been dedicated to the Epidermal Growth Factor Receptor (EGFR) due to its significant role in the pathogenesis of malignant tumors. In many types of cancers intracellular pathways modulated by EGFR have been identified as crucial factors influencing tumor survival and development. On the other hand, EGFR has also been shown to be a promising molecular target for potential therapeutic agents. Attempts to modify the signal transduction exerted by EGF have been made either by blocking the activity of certain elements of the EGFR pathway or by direct inhibition of the EGF receptor itself. It has also been demonstrated that the use of monoclonal antibodies to block the EGF receptor increases the effectiveness of conventional anticancer agents such as cisplatin. Thus, many anticancer therapies based on inhibitors of the selected components of the EGFR signaling pathway have been established, and many of them apply monoclonal antibodies.
Receptor naskórkowego czynnika wzrostu EGFR (Epidermal Growth Factor Receptor), ze względu na jego ważny udział w patogenezie nowotworów złośliwych, jest obiektem intensywnych badań naukowych ostatnich lat. W wielu typach nowotworów wewnątrzkomórkowe szlaki sygnalizacyjne pobudzane przez EGFR mają wręcz kluczowe znaczenie w ich rozwoju. Z drugiej strony wykazano, iż EGFR może stanowić bardzo obiecujący punkt uchwytu dla czynników terapeutycznych. Podjęto próby modyfikacji transdukcji sygnału przekazywanego przez aktywny EGFR wewnątrz komórek poprzez blokowanie aktywności elementów tego szlaku bądź samego receptora. Wykazano też, że blokowanie receptora EGFR przez przeciwciała monoklonalne podwyższa efektywność stosowanych w terapii kon-wencjonalnych czynników przeciwnowotworowych, np. cisplatyny. Dodatkowo opracowano wiele terapii przeciwno-wotworowych opierając się na zastosowaniu inhibitorów wybranych, kluczowych składowych szlaku sygnalizacyj-nego EGFR, z których wiele bazuje na zastosowaniu przeciwciał monoklonalnych.
Źródło:
Annales Academiae Medicae Silesiensis; 2018, 72; 12-20
1734-025X
Pojawia się w:
Annales Academiae Medicae Silesiensis
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
CRK5 as a convergence and abiotic stress node between senescence responses
Autorzy:
Burdiak, P.
Glow, D.
Rusaczonek, A.
Karpinski, S.
Powiązania:
https://bibliotekanauki.pl/articles/80997.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
abiotic stress
plant
receptor-like kinase
signal transduction
cysteine
transcription factor
Arabidopsis thaliana
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The role of miRNAs upon metal stress in Arabidopsis thaliana
Autorzy:
Gielen, H.
Remans, T.
Vangronsveli, J.
Cuypers, A.
Powiązania:
https://bibliotekanauki.pl/articles/80906.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
microRNA
metal stress
plant
Arabidopsis thaliana
reactive oxygen species
gene expression
oxidative stress
signal transduction
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 28

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies