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    Tytuł:
    Adipose-derived stem cells: a review of osteogenesis differentiation
    Autorzy:
    Skubis, Aleksandra
    Sikora, Bartosz
    Zmarzły, Nikola
    Wojdas, Emilia
    Mazurek, Urszula
    Powiązania:
    https://bibliotekanauki.pl/articles/764811.pdf
    Data publikacji:
    2016
    Wydawca:
    Uniwersytet Łódzki. Wydawnictwo Uniwersytetu Łódzkiego
    Tematy:
    mesenchymal stem cells
    regenerative medicine
    adipose tissue
    Opis:
    Komórki macierzyste to komórki posiadające zdolność nieograniczonych podziałów oraz umiejętność do wielokierunkowego różnicowania. Mezenchymalne komórki macierzyste (MSC) to somatyczne komórki występujące w tkankach i narządach dorosłego organizmu takich jak: szpik kostny, tkanka tłuszczowa oraz mięśnie. Ulegają one różnicowaniu w kierunku komórek pochodzących z jednego listka zarodkowego jakim jest mezoderma. To pozwala na wykorzystanie ich w regeneracji chrząstki, kości lub wypełnienia ubytków tkanką tłuszczowa między innymi w chirurgi plastycznej. Obecnie głównym źródłem z którego pozyskiwano MSC był szpik kostny, jednak coraz szersze zastosowanie wykazuje tkanka tłuszczowa. Komórki z niej pochodzące wykazują takie same właściwości jak te pochodzące z szpiku kostnego, a procedura izolacji jest dużo mniej inwazyjna dla pacjenta. Bardzo często natomiast ich ilość jest nieporównywanie większa. Stąd też niniejsza praca porusza  temat wykorzystania MSC z tkanki tłuszczowej w regeneracji tkanki kostnej.
    This review article provides an overview on adipose-derived stem cells (ADSCs) for implications in bone tissue regeneration. Firstly this article focuses on mesenchymal stem cells (MSCs) which are object of interest in regenerative medicine. Stem cells have unlimited potential for self-renewal and develop into various cell types. They are used for many therapies such as bone tissue regeneration. Adipose tissue is one of the main sources of mesenchymal stem cells (MSCs). Regenerative medicine intends to differentiate ADSC along specific lineage pathways to effect repair of damaged or failing organs. For further clinical applications it is necessary to understand mechanisms involved in ADSCs proliferation and differentiation. Second part of manuscript based on osteogenesis differentiation of stem cells. Bones are highly regenerative organs but there are still many problems with therapy of large bone defects. Sometimes there is necessary to make a replacement or expansion new bone tissue. Stem cells might be a good solution for this especially ADSCs which manage differentiate into osteoblast in in vitro and in vivo conditions.
    Źródło:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica; 2016, 12; 38-47
    1730-2366
    2083-8484
    Pojawia się w:
    Acta Universitatis Lodziensis. Folia Biologica et Oecologica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Stem cells and their derivatives – hopes and challenges in regenerative medicine
    Autorzy:
    Zuba-Surma, E. K.
    Powiązania:
    https://bibliotekanauki.pl/articles/284472.pdf
    Data publikacji:
    2014
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    regenerative medicine
    tissue engineering
    biomaterials
    Opis:
    Major goals of contemporary regenerative medicine focus on improvement of irreversible damage of multiple organs and tissues by employing several approaches including recent achievements of cellbased therapies and tissue engineering. Several types of stem cells (SCs) such as bone marrow (BM)- derived mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs) as well as SCs with multi- and pluripotent characteristics (PSCs) have been postulated as potential source of cells for therapy. Recently, embryonic stem cells (ESCs) and so called induced pluripotent stem cells (iPS cells) representing “genetically induced” SCs with high differentiation potential, have brought great hope to the field of regenerative medicine and clinical applications. When combined with modern accomplishments of tissue engineering including biocompatible carriers and scaffolds, SCs become leading targets for cell -based regenerative applications. Although the variety of stem/ progenitor cells have been applied in experimental therapies of several organs injuries, there is still no agreement in scientific and clinical world which subpopulation/s of cells would be the most efficient in such treatment. Moreover, multiple obstacles needs to be overcome prior to optimal application of SCs in regeneration including optimization of ex vivo isolation and expansion conditions or limiting vast adverse features of some SC fractions such as teratogenic potential of ESCs and iPS cells. Recently, stem cell- derived bioactive components such as cellular microvesicles (MVs) are postulated to play important role in mediating SC activity following transplantation. MVs representing bioactive components carrying SC- derived transcripts (mRNA, miRNA), proteins, enzymes and receptors may participate in tissue regeneration via stimulation of endogenous repair mechanism by activating endogenous target cells in damaged organs. Thus, the newest trends in regenerative medicine would focus not only on combined applications of biocompatible materials with SC subpopulations, but also with their bioactive acellular components including microvesicles. Unquestionably, successful applications of stem/ progenitor cells and their derivatives in regenerative medicine would need to be safe, ethically acceptable and therapeutically efficient. Sources and application protocols for such optimal stem cell therapy are still being optimized and need scientific discussion.
    Źródło:
    Engineering of Biomaterials; 2014, 17, no. 128-129; 102
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Prospects for the use of the achievements of regenerative medicine in otorhinolaryngology
    Autorzy:
    Ciechanowicz, Andrzej K
    Powiązania:
    https://bibliotekanauki.pl/articles/1400044.pdf
    Data publikacji:
    2017
    Wydawca:
    Index Copernicus International
    Tematy:
    regenerative medicine
    pluripotent stem cells
    embryonic stem cells
    very small embryonic-like stem cells
    tissue engineering
    Opis:
    Regenerative medicine is focusing on searching for stem cells, which can be efficiently and safely used for regeneration of damaged tissues and organs. Pluripotent stem cells would be ideal for this purpose. It is because they have the ability to differentiate into cells of all three germ layers (ecto-, meso- and endoderm). One of the sources of their isolation are embryos. For many years, they are made unsuccessful attempts to use of very controversial embryonic stem cells that are isolated from embryos. So strong ethical controversy forced scientists to look for other, undoubted ethically, sources of pluripotent stem cells. Induced pluripotent stem cells are proposed, as a more promising alternative to cells isolated from embryos. Unfortunately, both embryonic stem cells and induced pluripotent stem cells tend to genetic instability leading to the formation of teratomas. In parallel studies scientists try to use of stem cells isolated from adult tissues (e.g. bone marrow cells or adipose tissue) in the regeneration of parenchymal organs. Unfortunately, there is no convincing evidence for most of these cells that can regenerate damaged parenchymal organs. Regenerative medicine more frequently is employed in the otorhinolaryngological therapies. More and more researchers’ efforts are put into the development of an effective method of stimulation (in vitro) of pluripotent stem cells isolated from adult tissue for differentiation of the renewable progenitor stem cells which can keep their potential after transplantation into the recipient (e.g. in the treatment of imbalances or hearing loss). Moreover, there are promising methods for employing of the stem cells potential in tissue engineering as they are more effectively introduced as a clinical therapies.
    Źródło:
    Polski Przegląd Otorynolaryngologiczny; 2017, 6, 1; 1-7
    2084-5308
    2300-7338
    Pojawia się w:
    Polski Przegląd Otorynolaryngologiczny
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cell therapy for regenerative medicine: facts and controversy
    Fakty i kontrowersje związane z terapią komórkową w medycynie regeneracyjnej
    Autorzy:
    Sarnowska, Anna
    Machaliński, Bogusław
    Radoszkiewicz, Klaudia
    Bużańska, Leonora
    Powiązania:
    https://bibliotekanauki.pl/articles/2121315.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    cell therapy
    regenerative medicine
    human mesenchymal stem cells
    human induced pluripotent stem cells
    Opis:
    Cellular therapy, as a part of regenerative medicine, implies to the treatment of human disorders with cells as a medical product, so called – “living drugs”. Usually such therapy is applied when other alternative efficient pharmacological therapies are not available. Stem cells of different origin: 1) tissue specific e.g. hematopethic, epithelial, neuronal, limbal; 2) mesenchymal stem cells (MSC) harvested from variety of tissues; 3) pluripotent stem cells: embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC) – serve as a source of cells for regenerative medicine application, depending upon disease and application re- quirements. Currently MSC are the type of stem cells that are most frequently used in registered regenerative medicine clinical trials. In this paper we provide the information on the application of cell therapy in orthopedics, hematology, ophthalmology, dermatology, gastrology and neurology. The influence of origin of MSCs and iPSCs on their mode of action as therapeutic, regenerative agents are discussed. Advantages and disadvantages of application of different cell types for cell therapy are underlined. Last, but not least current low regulations in Poland and requirements of European regulatory bodies for cell therapy are pointed out and discussed.
    Źródło:
    Nauka; 2021, 4; 67-92
    1231-8515
    Pojawia się w:
    Nauka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Current status and future prospects of genome-scale metabolic modeling to optimize the use of mesenchymal stem cells in regenerative medicine and biomaterials
    Autorzy:
    Sigurjonsson, Olafur E.
    Powiązania:
    https://bibliotekanauki.pl/articles/1844931.pdf
    Data publikacji:
    2020
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    regenerative medicine
    biomaterials
    mesenchymal stem cells
    medycyna regeneracyjna
    biomateriały
    metabolizm
    Opis:
    Mesenchymal stem cells are a promising source for externally grown tissue replacements and patient-specific immunomodulatory treatments. This promise has not yet been fulfilled in part due to production scaling issues and the need to maintain the correct phenotype after reimplantation. One aspect of extracorporeal growth that may be manipulated to optimize cell growth and differentiation is metabolism. The metabolism of MSCs changes during and in response to differentiation and immunomodulatory changes. MSC metabolism may be linked to functional differences but how this occurs and influences MSC function remains unclear. Understanding how MSC metabolism relates to cell function is however important as metabolite availability and environmental circumstances in the body may affect the success of implantation. Genome-scale constraint based metabolic modelling can be used as a tool to fill gaps in knowledge of MSC metabolism, acting as a framework to integrate and understand various data types (e.g., genomic, transcriptomic and metabolomic). These approaches have long been used to optimize the growth and productivity of bacterial production systems and are being increasingly used to provide insights into human health research. Production of tissue for implantation using MSCs requires both optimized production of cell mass and the understanding of the patient and phenotype specific metabolic situation. This review considers the current knowledge of MSC metabolism and how it may be optimized along with the current and future uses of genome scale constraint based metabolic modelling to further this aim.
    Źródło:
    Engineering of Biomaterials; 2020, 23, 158 spec. iss.; 7
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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