- Tytuł:
- Preparation, quality control and biodistribution studies of [61Cu]-oxinate for PET tumor imaging
- Autorzy:
-
Jalilian, A. R.
Zolghadri, S.
Faghihi, R.
Yousefnia, H.
Garousi, J.
Shafaii, K.
Bolourinovin, F. - Powiązania:
- https://bibliotekanauki.pl/articles/148094.pdf
- Data publikacji:
- 2009
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
copper-61
8-hydroxyquinoline
positron emission tomography
fibrosarcoma - Opis:
- Targeting apoptosis is an interesting issue in molecular imaging and various modalities have been presented. However, recent experiences in nuclear pharmacy demonstrated the application of small tracer molecules is more desired. This work was conducted for production of a radiolabeled copper complex, i.e. 61Cu-oxinate as a potential PET tracer for apoptosis imaging in oncology. Cu-61 was prepared by natural zinc target irradiation with 22 MeV protons (150 miA) via the natZn(p, xn)61Cu nuclear reaction with a yield of 3.33 mCi/miAh. In order to obtain the best labeling method, optimization reactions were performed for pH, temperature and concentration followed by solid phase extraction. Biodistribution of the tracer was studied in wild-type and fibrosarcoma bearing mice. Under the optimized conditions, radio-thin-layer chromatography (RTLC) and HPLC showed radiochemical purities of 99.99% and 97% respectively (with a minimum specific activity of 16 Ci/mM). Biodistribution of the tracer in fibrosarcoma bearing mice demonstrated a significant tumor uptake after 3 h. Tumor:blood and tumor:muscle ratios were 2.0 and 6.0 after 3 h, respectively.
- Źródło:
-
Nukleonika; 2009, 54, 3; 175-179
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł