Temat: melanoma - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Current clinical management of malignant melanoma – diagnosis process and innovative therapies
Autorzy:: Kwiatkowski, Stanisław
Przystupski, Dawid
Kotowski, Krzysztof
Kolasińska, Karolina
Saczko, Jolanta
Kulbacka, Julita
Powiązania:: https://bibliotekanauki.pl/articles/1177464.pdf
Data publikacji:: 2018
Wydawca:: Przedsiębiorstwo Wydawnictw Naukowych Darwin / Scientific Publishing House DARWIN
Tematy:: AJCC
Melanoma malignum
dabrafenib
electrochemotherapy
ipilimumab
melanoma
melanoma staging
pembrolizumab
photodynamic therapy
vemurafenib
Opis:: Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
Źródło:: World Scientific News; 2018, 102; 30-46
2392-2192
Pojawia się w:: World Scientific News
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
Autorzy:: Drzewiecka, Agnieszka
Urbańska, Krystyna
Matuszak, Zenon
Pineiro, Marta
Arnaut, Luis
Habdas, Jan
Ratuszna, Alicja
Stochel, Grażyna
Powiązania:: https://bibliotekanauki.pl/articles/1044198.pdf
Data publikacji:: 2001
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: melanoma
porphyrins
photodynamic therapy
Opis:: We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off <630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm2 dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
Źródło:: Acta Biochimica Polonica; 2001, 48, 1; 277-282
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Indocyanine green as a prospective sensitizer for photodynamic therapy of melanomas.
Autorzy:: Urbanska, Krystyna
Romanowska-Dixon, Bożena
Matuszak, Zenon
Oszajca, Janusz
Nowak-Sliwinska, Patrycja
Stochel, Grażyna
Powiązania:: https://bibliotekanauki.pl/articles/1043767.pdf
Data publikacji:: 2002
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: melanoma
photodynamic therapy
indocyanine green
Opis:: Spectroscopic, photochemical and biological properties of indocyanine green (ICG) are presented. Light over 800 nm is effectively absorbed by ICG. This property as well as photochemical behaviour of ICG make it a very suitable dye for photodynamic treatment of melanoma cells. Cytotoxicity of ICG itself and the effect of photodynamic therapy (PDT) were evaluated by following the growth of human (SKMEL 188) and mouse (S91) melanoma cells. The surviving fraction of the cells irradiated (λex = 830 nm) vs non-irradiated, treated with the same dose of ICG, is significantly decreased (5- to 10-fold). These results show that ICG is a very promising dye for photodynamic therapy of melanomas.
Źródło:: Acta Biochimica Polonica; 2002, 49, 2; 387-391
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Photodynamic effects of two water soluble porphyrins evaluated on human malignant melanoma cells in vitro.
Autorzy:: Szurko, Agnieszka
Krämer-Marek, Gabriela
Wideł, Maria
Ratuszna, Alicja
Habdas, Jan
Kuś, Piotr
Powiązania:: https://bibliotekanauki.pl/articles/1043409.pdf
Data publikacji:: 2003
Wydawca:: Polskie Towarzystwo Biochemiczne
Tematy:: malignant melanoma
tumour megacolonies in vitro
necrosis
photodynamic therapy
synthetic porphyrins
apoptosis
Opis:: Two water soluble porphyrins: meso-tetra-4-N-methylpyridyl-porphyrin iodide (P1) and 5,10-di-(4-acetamidophenyl)-15,20-di-(4-N-methylpyridyl) porphyrin (P2) were synthesised and evaluated in respect to their photochemical and photophysical properties as well as biological activity. Cytotoxic and phototoxic effects were evaluated in human malignant melanoma Me45 line using clonogenic assay, cytological study of micronuclei, apoptosis and necrosis frequency and inhibition of growth of megacolonies. Both porphyrins were characterised by high UV and low visible light absorptions. Dark toxicity measured on the basis of the clonogenic assay and inhibition of megacolony growth area indicated that P1 was non-toxic at concentrations up to 50 μg/ml (42.14 μM) and P2 at concentrations up to 20 μg/ml (16.86 μM). The photodynamic effect induced by red light above 630 nm indicated that both porphyrins were able to inhibit growth of melanoma megacolonies at non-toxic concentrations. Cytologic examination showed that the predominant mode of cell death was necrosis.
Źródło:: Acta Biochimica Polonica; 2003, 50, 4; 1165-1174
0001-527X
Pojawia się w:: Acta Biochimica Polonica
Dostawca treści:: Biblioteka Nauki

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