- Tytuł:
- Cyanidin and peonidin inhibit SPCA-1 growth in vitro via inducing Cell Cycle Arrest and Apoptosis
- Autorzy:
-
Yue, Heng
Xu, Qianqian
Lv, Liuzhuang
Xu, Jianfeng
Fan, Hua
Wang, Wenhan - Powiązania:
- https://bibliotekanauki.pl/articles/895348.pdf
- Data publikacji:
- 2019-06-28
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
Lung cancer
apoptosis
cell cycle
SPCA-1
cyanidin
peonidin - Opis:
- Non-small cell lung cancer (NSCLC) accounts for the majority (85%) of all lung cancers. Although many therapies are available, 35–50% of patients with stage I or II NSCLC develop recurrence and metastasis. This study was designed to investigate the anti-tumor activity of cyanidin (Cy) and peonidin (Pn) on NSCLC cells (SPCA-1). SPCA-1 cell proliferation, cell cycle and early apoptosis were investigated after treatment with Cy and Pn. The underlying signaling mechanism was also explored by detecting the levels of apoptosis-related proteins using enzyme-linked immunosorbent assay (ELISA). Cy and Pn inhibited the viability of SPCA-1 cells with an IC50 of 141.08 μg/mL and 161.31 μg/mL, respectively. Meanwhile, Cy and Pn induced cell cycle arrest at G2/M phase. Cy and Pn treatment significantly increased the levels of Bax, P53, and Caspase-3, while decreasing that of Bcl-2, thereby inhibiting the growth of SPCA-1 cells. In conclusion, Cy and Pn induced early apoptosis of NSCLC cells through regulation of the levels on Caspase-3, Bax, Bcl-2, and P53. These results suggest Cy and Pn as potential anticancer drugs for the treatment of lung cancer.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 503-509
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł