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    Wyświetlanie 1-4 z 4
    Tytuł:
    Next-generation nutraceuticals: bioactive peptides from plant proteases
    Autorzy:
    Matkawala, Fatema
    Nighojkar, Sadhana
    Nighojkar, Anand
    Powiązania:
    https://bibliotekanauki.pl/articles/16648148.pdf
    Data publikacji:
    2022
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    ACE inhibitory
    antioxidant
    bioactive peptides
    nutraceuticals
    papain
    plant proteases
    Opis:
    Bioactive peptides are short and specific fragments of proteins with a wide range of biological activities that provide health benefits to the host. These natural peptides are safe and nontoxic and do not show any side effects. Nowadays, the production and characterization of bioactive peptides have been a key area of research as they show great potential as nutraceuticals and functional foods. Thus, bioactive peptides are considered next generation therapeutic agents that can replace pharmaceutical products with profound adverse effects in the near future. So far, proteolytic hydrolysis has been used as the method of choice for the large-scale production of bioactive peptides. Studies have reported that peptides with specific characteristics can be generated using a particular type of protease. Microbial proteases are the predominantly used ones because of the ease in their production and purification. However, recently, plant proteases have gained a renewed interest as they offer diversity and better specificity compared with other proteases. This review highlights the potential of plant proteases for the production of bioactive peptides and also describes the benefits of bioactive peptides as nutraceuticals.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2022, 103, 4; 397-408
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Theoretical studies of binding modes of two covalent inhibitors of cysteine proteases.
    Autorzy:
    Drabik, Piotr
    Politowska, Ewa
    Czaplewski, Cezary
    Kasprzykowski, Franciszek
    Łankiewicz, Leszek
    Ciarkowski, Jerzy
    Powiązania:
    https://bibliotekanauki.pl/articles/1044228.pdf
    Data publikacji:
    2000
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    cysteine proteases
    covalent protease inhibitors
    constrained simulated annealing
    papain
    molecular dynamics
    Opis:
    Physiological and pathological roles of cysteine proteases make them important targets for inhibitor development. Although highly potent inhibitors of this group of enzymes are known, their major drawback is a lack of sufficient specificity. Two cysteine protease covalent inhibitors, viz. (i) Z-RL-deoxo-V-peptide-epoxysuccinyl hybrid, and (ii) Z-RLVG-methyl-, have been developed and modeled in the catalytic pocket of papain, an archetypal thiol protease. A number of configurations have been generated and relaxed for each system using the AMBER force field. The catalytic pockets S3 and S4 appear rather elusive in view of the observed inhibitors' flexibility. This suggest rather limited chances for the development of selective structure-based inhibitors of thiol proteases, designed to exploit differences in the structure of catalytic pockets of various members of this family.
    Źródło:
    Acta Biochimica Polonica; 2000, 47, 4; 1061-1066
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Anisakis simplex stage III larvae upon the activity of proteases under in vitro conditions
    Autorzy:
    Dziekonska-Rynko, J
    Rokicki, J.
    Jablonowski, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/837165.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    protease activity
    stage
    papain
    pepsin
    trypsin
    larva
    Anisakis simplex
    in vitro
    Opis:
    The larvae of Anisakis simplex had the largest influence upon decreasing the activity of porcine pepsin. The activity of that enzyme in tests, where the larvae were present during the entire period of incubation, was lower than in the controls. No similar trends were observed in case of the solutions with bovine and porcine trypsin. The activity of those enzymes in the solutions containing the larvae was higher than in the controls. Only the activity of porcine trypsin after 10 h of incubation was slightly lower in the experimental sample than in the control, however, during the later hours the dynamics of the activity decrease of that enzyme in the controls was higher than in the experimental samples. The recorded activity of papain in the samples containing the larvae was higher than that in the controls during the entire time of the experiment.
    Źródło:
    Annals of Parasitology; 2002, 48, 2
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Influence of Anisakis simplex stage III larvae upon the activity of proteases under in vitro conditions
    Autorzy:
    Dziekońska-Rynko, J.
    Rokicki, J.
    Jabłonowski, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147699.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    protease activity
    stage
    papain
    pepsin
    trypsin
    larva
    Anisakis simplex
    in vitro
    Opis:
    The larvae of Anisakis simplex had the largest influence upon decreasing the activity of porcine pepsin. The activity of that enzyme in tests, where the larvae were present during the entire period of incubation, was lower than in the controls. No similar trends were observed in case of the solutions with bovine and porcine trypsin. The activity of those enzymes in the solutions containing the larvae was higher than in the controls. Only the activity of porcine trypsin after 10 h of incubation was slightly lower in the experimental sample than in the control, however, during the later hours the dynamics of the activity decrease of that enzyme in the controls was higher than in the experimental samples. The recorded activity of papain in the samples containing the larvae was higher than that in the controls during the entire time of the experiment.
    Źródło:
    Wiadomości Parazytologiczne; 2002, 48, 2; 217-223
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-4 z 4

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