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    Wyświetlanie 1-6 z 6
    Tytuł:
    Wrazliwosc na mikonazol i itrakonazol szczepow grzybow z rodzaju Candida wyodrebnionych od pacjentow hospitalizowanych i leczonych w trybie ambulatoryjnym
    Susceptibility to miconazole and itraconazole of Candida strains isolated from hospitalized and outpatient clinic patients
    Autorzy:
    Kurnatowska, A.K.
    Kwasniewska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/840111.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    mikonazol
    wrazliwosc na leki
    itrakonazol
    Candida
    parazytologia lekarska
    leczenie szpitalne
    pacjenci
    leki przeciwgrzybicze
    szczepy grzybow
    leczenie ambulatoryjne
    grzybice
    Źródło:
    Annals of Parasitology; 2009, 55, 4; 415-423
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wrażliwość na mikonazol i itrakonazol szczepów grzybów z rodzaju Candida wyodrębnionych od pacjentów hospitalizowanych i leczonych w trybie ambulatoryjnym
    Susceptibility to miconazole and itraconazole of Candida strains isolated from hospitalized and outpatient clinic patients
    Autorzy:
    Kurnatowska, A.K.
    Kwaśniewska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2143561.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    mikonazol
    wrazliwosc na leki
    itrakonazol
    Candida
    parazytologia lekarska
    leczenie szpitalne
    pacjenci
    leki przeciwgrzybicze
    szczepy grzybow
    leczenie ambulatoryjne
    grzybice
    Opis:
    It is known that fungi representing different genera and species can cause organ-limited or systemic infections after disrupting of the natural defense mechanisms in a human organism. The treatment of mycoses still encounters considerable difficulties. Therefore, in vitro assessment of the susceptibility of fungal strains to the antifungal agents now in use and to new drugs is needed more urgently than ever before. It should be emphasized that we treat the fungal susceptibility to antifungal drugs as a quantitative feature of the strain examined. The aim of the presently reported study was the evaluation of the antimycotic action of two azole compounds – miconazole and itraconazole (Janssen) against 205 Candida strains isolated from the various biological specimens of two groups of patients – hospitalized (group 1) and examined in outpatient clinic (group 2); differentiation of species and codes of these strains; analysis of dose-response curves and parameters of polygons of the azoles minimal inhibitory concentrations (MIC). The susceptibility to miconazole and itraconazole was estimated with the agar diffusion test on 3% Sabouraud’s agar – the method developed in our laboratory, using several different concentrations of the drug, which made the plotting of dose-response curves possible. The lowest concentration inhibiting the growth of fungal strain (MIC) was calculated using a transformed equation of rectilinear regression according to Kadłubowski. Species and fungal codes of isolated strains were evaluated according to the guidelines worked out in our department with the use of different media and biochemical tests (bioMérieux). Among 89 strains isolated from the hospitalized patients, six species of the genus Candida genus were found; one strain belonged to Trichosporon cutaneum species. The most frequently encountered species was Candida albicans (73%), which significantly dominated over C. tropicalis, C. parapsilosis, C. glabrata, C. lipolytica and C. famata. All strains from the second group of patients belonged to C. albicans species. In all C. albicans strains from both groups of patients, the most frequent assimilation code (2576174) was found. The miconazole MIC values for Candida strains isolated from the group 1 were characterized by a wide range of variation, from 0.0247mg/l to 6.826 mg/l, from group 2 – 0.0277 to 0.719 mg/l. The itraconazole MIC values were 0.011 to 2.813 mg/l, and 0.0103 to 0.718 mg/l, respectively. The analysis of mean values (x) of miconazole and itraconazole MICs and other parameters allowed us to find that the strains isolated from the patients of group 1 were significantly less susceptible to both drugs in comparison with the strains of the group 2 patients. Also, C. albicans strains from this group of patients had a significantly lower (x) MIC in comparison to the mean values for the most of Candida species isolated from the hospitalized patients (P<0.001). In conclusion, we have found that the most Candida strains from both groups of patients were susceptible to the examined antifungal agents. The strains isolated from the outpatient clinic patients were generally more susceptible especially to itraconazole in comparison with strains from hospitalized patients.
    Źródło:
    Wiadomości Parazytologiczne; 2009, 55, 4; 415-423
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Charakterystyka cech fenotypowych gatunkowych i wewnątrzgatunkowych szczepów grzybów wyodrębnionych z wybranych ontocenoz narządowych osób po przeszczepach nerek
    Autorzy:
    Kurnatowska, A.
    Kurnatowska, I.
    Kacprzyk, F.
    Chrzanowski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/2147753.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zmiennosc wewnatrzgatunkowa
    zmiennosc gatunkowa
    cechy fenotypowe
    zakazenia grzybicze
    nerki
    przeszczepy narzadowe
    parazytologia lekarska
    pacjenci
    szczepy grzybow
    narzady wewnetrzne
    Opis:
    Characteristics or phenotypic specific and intraspecific reatures of fungal strains isolated from the organ ontocenoses in patients after renal transplantation. The aim of present study was to describe 60 specific and intraspecific features of fungal strains isolated from the organ ontocenoses: oral cavity, rectum and genital organs in 32 patients undergoing permanent immunosupression after renal transplantation. Fungal strains identified using API 20 C and API 20 C AUX (bioMérieux). The activity or 19 hydrolases was investigated using API ZYM. Among 41 strains of fungi the following were found: Candida albicans (31 strains), C. glabrata (5), C. guilliermondii (2), C. krusei (2) and Saccharomyces cerevisiae (1). The number of fungal strains isolated from the oral cavity was the highest (21), less numerous from rectum (12) and the least from the genital organs (8). The enzymograms were described for all strains and the highest activity was noted in case of: e₆ -leucine arylamidase, e₁₁-phosphatase acid, e₃-esterase (C4), e₁₂-naphtol-AS-BI-phosphohydrolase. The activity of these enzymes is connected with higher pathogenicity of C. albicans strains.
    Źródło:
    Wiadomości Parazytologiczne; 2002, 48, 4; 425-433
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Charakterystyka cech fenotypowych gatunkowych i wewnatrzgatunkowych szczepow grzybow wyodrebnionych z wybranych ontocenoz narzadowych osob po przeszczepach nerek
    Autorzy:
    Kurnatowska, A
    Kurnatowska, I.
    Kacprzyk, F.
    Chrzanowski, W.
    Powiązania:
    https://bibliotekanauki.pl/articles/837373.pdf
    Data publikacji:
    2002
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    zmiennosc wewnatrzgatunkowa
    zmiennosc gatunkowa
    cechy fenotypowe
    zakazenia grzybicze
    nerki
    przeszczepy narzadowe
    parazytologia lekarska
    pacjenci
    szczepy grzybow
    narzady wewnetrzne
    Opis:
    Characteristics or phenotypic specific and intraspecific reatures of fungal strains isolated from the organ ontocenoses in patients after renal transplantation. The aim of present study was to describe 60 specific and intraspecific features of fungal strains isolated from the organ ontocenoses: oral cavity, rectum and genital organs in 32 patients undergoing permanent immunosupression after renal transplantation. Fungal strains identified using API 20 C and API 20 C AUX (bioMérieux). The activity or 19 hydrolases was investigated using API ZYM. Among 41 strains of fungi the following were found: Candida albicans (31 strains), C. glabrata (5), C. guilliermondii (2), C. krusei (2) and Saccharomyces cerevisiae (1). The number of fungal strains isolated from the oral cavity was the highest (21), less numerous from rectum (12) and the least from the genital organs (8). The enzymograms were described for all strains and the highest activity was noted in case of: e₆ -leucine arylamidase, e₁₁-phosphatase acid, e₃-esterase (C4), e₁₂-naphtol-AS-BI-phosphohydrolase. The activity of these enzymes is connected with higher pathogenicity of C. albicans strains.
    Źródło:
    Annals of Parasitology; 2002, 48, 4; 425-433
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena aktywnosci kwasnej proteazy asparaginowej szczepow Candida wyizolowanych z jamy ustnej u pacjentow z podwyzszonym ryzykiem zakazenia grzybami
    Autorzy:
    Rozga, A
    Kurnatowska, A.J.
    Raczynska-Witonska, G.
    Loga, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/841502.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    nowotwory
    aktywnosc proteolityczna
    choroby czlowieka
    rak krtani
    aktywnosc enzymatyczna
    Candida
    parazytologia lekarska
    pacjenci
    kwasna proteaza asparaginowa
    wymazy z jamy ustnej
    szczepy grzybow
    zaburzenia immunologiczne
    Opis:
    We have evaluated the activity of acid aspartic protease in 195 strains of Candida isolated from the oral cavity of three groups of patients. The first group comprised patients with cancer of the larynx qualified for surgery, the second- patients with neoplastic disease (Hodgkin's disease, lymphoma, acute granulocytic leukaemia, lymphatic leukaemia, lung cancer, multiple myeloma, stomach cancer, breast cancer) who were not treated, the third group- patients with neoplastic diseases treated by chemotherapy. The strains of fungi were differentiated using API 20C and Api 20C AUX tests according to the protocol adopted at the Department of Medical Parasitology and Biology, Medical University of Łódż. The activity of acid protease was studied by Staib method in Rózga modification. Almost all strains showed high and very high proteolytic activity. The rang of proteolysis zone of Candida strains from the three groups of patients varied from 2,5 to 12,5 mm. We have found the mean proteolytic zones of strains isolated from groups Iand III differed statistically significantly (p<0,001). Similarly, statisticall sihnificant difference was seen between these parameters for groups II and III (p<0,05), while there was no difference between strains from group I and II.
    Źródło:
    Annals of Parasitology; 2001, 47, 4; 883-890
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena aktywności kwaśnej proteazy asparaginowej szczepów Candida wyizolowanych z jamy ustnej u pacjentów z podwyższonym ryzykiem zakażenia grzybami
    EVALUTION OF ACTIVITY OF ACID ASPARTIC PROTEINASE IN CANDIDA STRAINS . ISOLATED FROM ORAL CAVITY OF PATIENTS WITH INCREASED RISK OF MYCOSIS
    Autorzy:
    Rózga, A.
    Kurnatowska, A.J.
    Raczyńska-Witońska, G.
    Loga, G.
    Powiązania:
    https://bibliotekanauki.pl/articles/2148245.pdf
    Data publikacji:
    2001
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    nowotwory
    aktywnosc proteolityczna
    choroby czlowieka
    rak krtani
    aktywnosc enzymatyczna
    Candida
    parazytologia lekarska
    pacjenci
    kwasna proteaza asparaginowa
    wymazy z jamy ustnej
    szczepy grzybow
    zaburzenia immunologiczne
    Opis:
    We have evaluated the activity of acid aspartic protease in 195 strains of Candida isolated from the oral cavity of three groups of patients. The first group comprised patients with cancer of the larynx qualified for surgery, the second- patients with neoplastic disease (Hodgkin's disease, lymphoma, acute granulocytic leukaemia, lymphatic leukaemia, lung cancer, multiple myeloma, stomach cancer, breast cancer) who were not treated, the third group- patients with neoplastic diseases treated by chemotherapy. The strains of fungi were differentiated using API 20C and Api 20C AUX tests according to the protocol adopted at the Department of Medical Parasitology and Biology, Medical University of Łódż. The activity of acid protease was studied by Staib method in Rózga modification. Almost all strains showed high and very high proteolytic activity. The rang of proteolysis zone of Candida strains from the three groups of patients varied from 2,5 to 12,5 mm. We have found the mean proteolytic zones of strains isolated from groups Iand III differed statistically significantly (p<0,001). Similarly, statisticall sihnificant difference was seen between these parameters for groups II and III (p<0,05), while there was no difference between strains from group I and II.
    Źródło:
    Wiadomości Parazytologiczne; 2001, 47, 4; 883-890
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-6 z 6

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