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Wyświetlanie 1-2 z 2
Tytuł:
Comprehensive tackling to the safe handling of hazardous drugs: a multidisciplinary approach to clinical practice
Autorzy:
Vuelta-Arce, María
Chiapella-Micó, Carlos
Mestre-Prad, Maria T.
Teixidó-Huerta, Xavier
del Estal-Jiménez, Jorge
Rodríguez-Gías, Ester
Guinovart-Alemany, Montserrat
Powiązania:
https://bibliotekanauki.pl/articles/2116528.pdf
Data publikacji:
2020-09-17
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
occupational exposure
drug safety
personal protective equipment
hazardous drugs
safe handling
drug compounding
Opis:
ObjectivesThe aim of this study is to present the adaptation and implementation of the recommendations of the National Institute for Safety and Health at Work (Instituto Nacional de Seguridad y Salud en el Trabajo – INSHT) in the authors’ hospital to achieve a safer handling of hazardous drugs.Material and MethodsIn 2016, INSHT published the first document on hazardous drugs in Spain. In the authors’ center, a project was developed to implement the recommendations presented in that document in 2 phases: 1) analysis: to identify drugs and processes susceptible to not being handled as hazardous, and to search for safer alternatives and preventive measures; and 2) development: to ensure information, training, the adaptation of standardized work procedures, the minimization of risks associated with handling, safety devices, personal protective equipment (PPE), as well as health monitoring.ResultsThe authors detected 80 commercial presentations manipulated without adhering to safety conditions, mainly oral (74%) from lists 1 (7.5%), 2 (37.5%) and 3 (55%) of the National Institute for Occupational Safety and Health. The following measures were envisaged to reduce the risk: introducing new presentations (4 lower doses, 1 liquid dose) and centralizing new preparations in the pharmacy service (11 oral formulas, 6 parenteral drugs). Management, spillage and exposure procedures were adapted. Safety measures were included in the prescription and administration applications, and there were some indications of risks in the storage. Overall, 48 referents and 690 nurses were trained. Each unit was provided with PPE and safety devices (e.g., closed systems, RX CRUSH®). The steps prior to the administration were moved to the patient’s bedside to align patient and professional safety. During the first 6 months after the implementation, 22 cases of pregnancy (64% among the nursing staff), 4 cases of lactation, and 1 case of conceiving problems were reported. In the cases of oxytocin and the repackaging of list 3, risk management was applied.ConclusionsThe multidisciplinary approach has allowed to achieve a global and safer control of hazardous drugs with a minimal impact on the center. It is important to continuously evaluate the effects of these measures, and to take into account the data of this analysis and any possible new evidence.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2020, 33, 5; 621-634
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Assessment of buccal mucosa genotoxicity in insecticide-exposed urban fumigators in Cali, Colombia
Autorzy:
Londoño-Velasco, Elizabeth
Asencio-Santofimio, Helberg
Ortega-Avila, Jose G.
Rosero-Caldón, Aldair B.
Aristizabal-Grisales, Juan C.
Rey-Henao, Laura
Vargas-Rivera, Jairo A.
Vergara-Escudero, Enrique
Powiązania:
https://bibliotekanauki.pl/articles/28762056.pdf
Data publikacji:
2024-03-05
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
insecticides
occupational exposure
buccal micronucleus cytome assay
DNA damage
biomarker
personal protective equipment
Opis:
Objectives This study aimed to evaluate cytogenetic damage in the buccal mucosa of non-exposed subjects (N = 33) and insecticide-exposed fumigators (N = 31) in the urban area of Cali, Colombia. Material and Methods Through a questionnaire sociodemographic data, anthropometric measurements, state of health, and lifestyle were collected. Buccal micronucleus cytome (BMCyt) assay was using for evaluate cytogenetic damage. Results The study showed that all fumigators used adequate personal protective equipment (PPE) and had low alcohol consumption. The authors did not find significant differences in BMCyt biomarkers between the groups (p > 0.05). Multivariate analysis showed a 13% increase in micronucleus (MN) frequency for every year of increasing age (OR = 1.13, p = 0.029), and higher MN with the decrease in daily fruit consumption (OR = 4.71, p = 0.084), without statistical significance. Conclusions The results between groups could be related to healthy habits and PPE use among the subjects.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2024, 37, 1; 128-137
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-2 z 2

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