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    Wyświetlanie 1-2 z 2
    Tytuł:
    Anticancer activity of some polyamine derivatives on human prostate and breast cancer cell lines
    Autorzy:
    Szumilak, Marta
    Galdyszynska, Malgorzata
    Dominska, Kamila
    Stanczak, Andrzej
    Piastowska-Ciesielska, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1038652.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    polyamine derivatives
    prostate cancer
    breast cancer
    mitochondrial potential
    cell cycle
    apoptosis
    Opis:
    The aim of this study was to expand our knowledge about anticancer activity of some polyamine derivatives with quinoline or chromane as terminal moieties. Tested compounds were evaluated in vitro towards metastatic human prostate adenocarcinoma (PC3), human carcinoma (DU145) and mammary gland adenocarcinoma (MCF7) cell lines. Cell viability was estimated on the basis of mitochondrial metabolic activity using water-soluble tetrazolium WST1 to establish effective concentrations of the tested compounds under experimental conditions. Cytotoxic potential of polyamine derivatives was determined by the measurement of lactate dehydrogenase activity released from damaged cells, changes in mitochondrial membrane potential, the cell cycle distribution analysis and apoptosis assay. It was revealed that the tested polyamine derivatives differed markedly in their antiproliferative activity. Bischromane derivative 5a exhibited a rather cytostatic than cytotoxic effect on the tested cells, whereas quinoline derivative 3a caused changes in cell membrane integrity, inhibited cell cycle progression, as well as induced apoptosis of prostate and breast cancer cells which suggest its potential application in cancer therapy.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 2; 307-313
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    The influence of Viburnum opulus polyphenolic compounds on metabolic activity and migration of HeLa and MCF cells
    Autorzy:
    Zakłos-Szyda, Małgorzata
    Pawlik, Nina
    Powiązania:
    https://bibliotekanauki.pl/articles/105848.pdf
    Data publikacji:
    2019
    Wydawca:
    Centrum Badań i Innowacji Pro-Akademia
    Tematy:
    Viburnum opulus
    polyphenols
    cancer cells migration
    mitochondrial potential
    antioxidant effect
    polifenole
    migracja komórek rakowych
    potencjał mitochondrialny
    działanie przeciwutleniające
    Opis:
    In recent years, research of antitumor activity of natural compounds isolated from plant material has increased. Polyphenols have gained significant attention due to their proapoptotic abilities and their involvement in migration and inhibition of metastasis processes. The anticancer effects of polyphenolic extracts of Viburnum opulus fruit against human breast (MCF-7) and cervical (HeLa) cancer cell lines have been confirmed in this study. It was demonstrated that the tested preparations (methanol – M and acetone – A from pomace, juice – J and juice after extraction to the solid phase SPE – PF) show cytotoxic activity and regulate the migration process of cancer cells. The degree of inhibition of cell migration was measured at two times - 24 h and 48 h after addition of the tested preparations. The highest toxicity towards both cell lines was demonstrated by the polyphenol fraction obtained after juice purification SPE (IC50 values at concentration of 63,541 and 19,380 μg/mL for HeLa and MCF cell lines, respectively). At the same time, the same preparation inhibited cell migration the most (nearly 70% compared to controls at both times at the concertation of 15 and 30 μg/mL). All preparations showed the antioxidant ability, but the Viburnum opulus juice (200 and 350 μg/mL) and the preparation after its purification (15 and 30 μg/mL) have larger ability to inhibit the intracellular oxidative stress (30-40%) than preparation obtained from pomace (nearly by 20% at concentration of 20 and 50 μg/mL of M and A). Despite the antioxidative capacity of the preparations, they simultaneously decreased cellular mitochondrial potential. The results obtained indicate the high potential of components of Viburnum opulus polyphenolic compounds can be used in the production of innovative dietary supplements or pharmacological preparations for people with an increased risk or inclination towards developing breast or cervical cancer.
    Źródło:
    Acta Innovations; 2019, 31; 33-42
    2300-5599
    Pojawia się w:
    Acta Innovations
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-2 z 2

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