- Tytuł:
- Modulation of the human preadipocyte mitochondrial activity by beta-carotene
- Autorzy:
-
Śliwa, Agnieszka
Góralska, Joanna
Czech, Urszula
Gruca, Anna
Polus, Anna
Zapała, Barbara
Dembińska-Kieć, Aldona - Powiązania:
- https://bibliotekanauki.pl/articles/1039768.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
oxidative phosphorylation
preadipocytes
mitochondria
beta-carotene - Opis:
- Increased ROS generation by the overload by metabolic substrates mitochondria paralleled by decrease of antioxidant activity are typical events found in metabolic syndrome and diabetes type 2. Metabolites of beta-carotene (BC) such as retinoic acid (RA), as well as low concentration of reactive oxygen species (ROS) modify the mitochondrial bioenergetic function. The aim of the study was to investigate the effect of beta-carotene on mitochondrial activity in human preadipocytes. BC used in concentrations, 10 or 30 µM, decreased mitochondrial membrane potential, inhibited mitochondrial respiration and decreased cellular ATP content. We conclude, that BC, the known antioxidant may decrease oxidative phosphorylation capacity of mitochondria.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 1; 39-41
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł