- Tytuł:
- Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
- Autorzy:
-
Reiter, Russel
Tan, Dun-xian
Mayo, Juan
Sainz, Rosa
Leon, Josefa
Czarnocki, Zbigniew - Powiązania:
- https://bibliotekanauki.pl/articles/1043401.pdf
- Data publikacji:
- 2003
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
neurodegeneration
respiratory distress
melatonin
sepsis
free radicals
antioxidant enzymes
antioxidant - Opis:
- This brief resume enumerates the multiple actions of melatonin as an antioxidant. This indoleamine is produced in the vertebrate pineal gland, the retina and possibly some other organs. Additionally, however, it is found in invertebrates, bacteria, unicellular organisms as well as in plants, all of which do not have a pineal gland. Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiency of other antioxidants. There may be other functions of melatonin, yet undiscovered, which enhance its ability to protect against molecular damage by oxygen and nitrogen-based toxic reactants. Numerous in vitro and in vivo studies have documented the ability of both physiological and pharmacological concentrations to melatonin to protect against free radical destruction. Furthermore, clinical tests utilizing melatonin have proven highly successful; because of the positive outcomes of these studies, melatonin's use in disease states and processes where free radical damage is involved should be increased.
- Źródło:
-
Acta Biochimica Polonica; 2003, 50, 4; 1129-1146
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł