Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "liver" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-12 z 12
    Tytuł:
    Circulating cytokeratin-18 and tumour necrosis factor-α in patients with alcoholic liver cirrhosis
    Autorzy:
    Prystupa, Andrzej
    Kiciński, Paweł
    Niedziałek, Jarosław
    Toruń-Jurkowska, Anna
    Boguszewska-Czubara, Anna
    Luchowska-Kocot, Dorota
    Ochal, Andrzej
    Jojczuk, Mariusz
    Sak, Jarosław
    Powiązania:
    https://bibliotekanauki.pl/articles/972347.pdf
    Data publikacji:
    2016
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    liver cirrhosis
    alcohol
    apoptosis markers
    Opis:
    Aims. The aim of the study was to assess the usefulness of TNF-α and CK-18 as diagnostic markers of alcoholic liver cirrhosis. Additionally, the effects of the stage of liver cirrhosis on concentrations of TNF-α and CK-18, as well as their correlation, were evaluated. Materials and method. Sixty-two patients with alcoholic liver cirrhosis treated in various hospitals were randomly enrolled. The stage of cirrhosis was assessed according to the Child-Turcotte-Pugh scoring system. The control group consisted of 31 healthy people without liver disease. Concentrations of TNF-α and cytokeratin-18 in blood plasma of patients and controls were measured using the sandwich enzyme immunoassay technique, with commercially available quantitative ELISA test kits. Results. The concentration of CK-18 was statistically higher in patients with alcoholic liver cirrhosis, compared to the control group. The concentration of TNF-α was significantly higher in patients with alcoholic liver cirrhosis, compared to the control group. Higher concentrations of TNF-α were found only in patients with stage C and B alcoholic liver cirrhosis, compared to healthy persons. Conclusions. The levels of TNF-α and total CK-18 were higher in patients with alcoholic liver cirrhosis than in healthy individuals. No correlation was found between the level of CK-18 and stage of liver cirrhosis.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2016, 10, 2; 87-90
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Arginase isoenzymes in human cirrhotic liver
    Autorzy:
    Chrzanowska, Alicja
    Gajewska, Beata
    Barańczyk-Kuźma, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1040542.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    arginase activity
    liver cirrhosis
    isoenzyme expression
    Opis:
    Cirrhosis leads to an inability of the liver to perform its biochemical functions. It can also lead to hepatocellular carcinoma in which, as we showed lately, arginase isoenzyme pattern changes. The present work presents our results on arginase isoenzymes and their possible role in liver cirrhosis. The study was performed on tissues obtained during liver transplantation from 60 patients with liver cirrhosis, and on samples of histologically normal liver (control) from 40 patients with benign or colorectal cancer liver metastases removed during surgery, 6-7 cm from the tumor border. Arginase isoenzymes AI (so-called liver-type arginase) and AII (called extrahepatic arginase) were identified by Western blotting and isolated by ion-exchange chromatography. Their expression on mRNA level was studied by RT-PCR. A significant decrease in arginase activity, dependent of the liver clinical stage, was observed in cirrhotic tissue. Arginase AI activity and its mRNA level were significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII were concurrently raised, as compared to normal liver. Since arginase AI is a key enzyme of the urea cycle, whereas arginase AII most probably takes part in the biosynthesis of ornithine and polyamines, the defective ammonia inactivation and increased collagen biosynthesis observed in cirrhotic liver may be related to the changes in arginase AI and AII levels, respectively.
    Źródło:
    Acta Biochimica Polonica; 2009, 56, 3; 465-469
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Features of pharmacotherapy of hepatic encephalopathy manifestations in liver cirrhosis
    Autorzy:
    Maretskyi, V.
    Lobanets, N.
    Powiązania:
    https://bibliotekanauki.pl/articles/2052423.pdf
    Data publikacji:
    2015
    Wydawca:
    Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
    Tematy:
    hepatic encephalopathy
    liver cirrhosis
    psychometric test
    Opis:
    The aim of this work is to study the effect of drug mebikar on the clinical manifestations of hepatic encephalopathy in patients with liver cirrhosis. The study involved 34 patients with cirrhosis of different etiologies. The average age of the examined patients was (48.5±0.9) years, that prevailed patients of working age, indicating the medical and social significance of the problem of early diagnosis and adequate treatment of cirrhosis. One of the most frequent complications of cirrhosis is hepatic encephalopathy. In addition to conventional clinical and laboratory findings in patients with liver cirrhosis, severities of hepatic encephalopathy were determined according to West-Haven criteria before and after treatment. In patients with liver cirrhosis was established the presence of latent or clinically expressed hepatic encephalopathy. The treatment of the control group of patients consisted of the following drugs: essential phospholipids, mixture of sorbitol and major ions, arginine glutamate, furosemide, verospiron, lactulose, amoxicillin trihydrate and lansoprazole. In the complex treatment of the main group of patients medicine mebikar was administered additionally. Analysis of the clinical manifestations of hepatic encephalopathy showed a marked improvement in patients who received additional treatment with mebikar. Specifically, the incidences of mood changes as well as anxiety decreased in this group on average of 38% compared with those patients without an additional treatment with mebikar. Also, sleep disturbances in the main group was observed to be lower by 7.2% compared to those in the control group. Inclusion in the treatment of patients with liver cirrhosis, the drug mebikar – a daytime tranquilizer with anxiolytic properties reduces neurotic disorders, improves emotional state which may indicate a regression in the manifestations of hepatic encephalopathy thereby improving the quality of life of patients and thus substantiating an expedient inclusion of mebikar an anxiolytic drug to the complex therapy of patients with liver cirrhosis.
    Źródło:
    Health Problems of Civilization; 2015, 09, 2; 31-34
    2353-6942
    2354-0265
    Pojawia się w:
    Health Problems of Civilization
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wybrane aspekty opieki pielęgniarskiej wobec pacjentki z marskością wątroby w przebiegu choroby Wilsona
    Selected aspects of nursing care for a patient with liver cirrhosis in the course of Wilsons disease
    Autorzy:
    Szambelan, Julita
    Haor, Beata
    Pietrzak, Monika
    Powiązania:
    https://bibliotekanauki.pl/articles/1029624.pdf
    Data publikacji:
    2018
    Wydawca:
    Państwowa Uczelnia Zawodowa we Włocławku
    Tematy:
    wilson's disease
    nursing process
    icnp®
    liver cirrhosis
    Opis:
    Introduction. Wilson's disease is a real threat to patients' quality of life. It leads to significant neurological deficits, psychiatric disorders and mainly severe liver dysfunctions. Aim. The aim of the study is to analyse selected aspects of nursing care for a patient in the course of Wilson's disease, using terms derived from ICNP®. Case study. The case report concerns a patient at a young age ,hospitalised due to exacerbation of Wilson's disease symptoms. Discussion. Wilson's disease mainly affects young people. Therefore, it is necessary to design such nursing care, which, apart from solving the somatic problems of the patient, does not affect their autonomy and minimizes deficits in the scope of social roles performed so far. Conclusions. The use of ICNP® in the planning of nursing care for a patient in the course of Wilson's disease may significantly support the implementation of systematic actions aimed at improving the quality of her life.
    Wstęp. Choroba Wilsona stanowi realne zagrożenie dla jakości życia pacjentów. Prowadzi bowiem do istotnych deficytów neurologicznych, zaburzeń o podłożu psychiatrycznym a głównie poważnych dysfunkcji wątroby. Cel pracy. Celem opracowania analiza wybranych aspektów opieki pielęgniarskiej wobec pacjentki w przebiegu choroby Wilsona, z wykorzystaniem terminów zaczerpniętych z ICNP®. Prezentacja przypadku. Opis przypadku dotyczy pacjentki w młodym wieku hospitalizowanej w związku z zaostrzeniem objawów choroby Wilsona. Dyskusja. Choroba Wilsona dotyczy głównie osób młodych. Niezbędne jest zatem projektowanie takiej opieki pielęgniarskiej, która poza rozwiązywaniem somatycznych problemów chorego, nie narusza ich autonomii i minimalizuje deficyty w zakresie dotychczas pełnionych ról społecznych. Wnioski. Zastosowanie ICNP® w planowaniu opieki pielęgniarskiej wobec pacjentki w przebiegu choroby Wilsona może istotnie sprzyjać wdrażaniu systematycznych działań służących poprawie jakości jej życia.
    Źródło:
    Innowacje w Pielęgniarstwie i Naukach o Zdrowiu; 2018, 3, 1; 82-103
    2451-1846
    Pojawia się w:
    Innowacje w Pielęgniarstwie i Naukach o Zdrowiu
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Spontaneous large hematoma of rectus abdominis muscle as complication of plasma coagulation disorders in 32-year-old man with terminal liver cirrhosis
    Samoistny duży krwiak mięśnia prostego brzucha jako powikłanie osoczowych zaburzeń krzepnięcia u 32-letniego mężczyzny z marskością wątroby w stadium terminalnym
    Autorzy:
    Jakubiak, Grzegorz K.
    Pietrzak, Mikołaj
    Stanek, Agata
    Cieślar, Grzegorz
    Powiązania:
    https://bibliotekanauki.pl/articles/52376303.pdf
    Data publikacji:
    2024-10-29
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    liver cirrhosis
    alcoholic liver disease
    hemorrhagic diathesis
    hematoma
    marskość wątroby
    alkoholowa choroba wątroby
    skaza krwotoczna
    krwiak
    Opis:
    Liver cirrhosis and its complications constitute one of the most important causes of hospitalization in internal medicine departments. Liver cirrhosis is not a homogeneous disease entity, but is the final stage of many different liver diseases, and the most important causes leading to the development of liver cirrhosis are alcoholic liver disease and viral hepatitis. One of the typical complications of liver cirrhosis are symptoms of bleeding diathesis. The most common bleeding complication in patients with liver cirrhosis is bleeding from the upper gastrointestinal tract. The aim of this publication is to present a case report of a 32-year-old man in the terminal stage, hospitalized due to decompensated alcoholic cirrhosis of the liver, who during hospitalization developed a spontaneous large hematoma in the rectus abdominis muscle on the left side. The presented case report shows that in the care of patients with decompensated liver cirrhosis, vigilance must be maintained to recognize bleeding complications, including those with an atypical clinical course.
    Marskość wątroby oraz jej powikłania stanowią jedną z najważniejszych przyczyn hospitalizacji na oddziałach internistycznych. Marskość wątroby nie stanowi jednorodnej jednostki chorobowej, lecz jest końcowym stadium wielu różnych chorób wątroby, a najważniejszymi przyczynami prowadzącymi do jej rozwoju są alkoholowa choroba wątroby oraz wirusowe zapalenia wątroby. Jednym z typowych powikłań marskości wątroby są objawy skazy krwotocznej. Najczęstszym powikłaniem krwotocznym u chorych z marskością wątroby jest krwawienie z górnego odcinka przewodu pokarmowego. Celem niniejszej pracy jest przedstawienie opisu przypadku 32-letniego mężczyzny w stadium terminalnym, hospitalizowanego z powodu niewyrównanej alkoholowej marskości wątroby, u którego w trakcie hospitalizacji wystąpił samoistny duży krwiak w obrębie mięśnia prostego brzucha po stronie lewej. Opisany przypadek pokazuje, że w opiece nad chorymi z niewyrównaną marskością wątroby należy zachowywać czujność pod kątem rozpoznania powikłań krwotocznych, również takich o nietypowym przebiegu klinicznym.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2024, 78; 282-286
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Pathogenesis and clinical consequences of iron overload in chronic hepatitis C - impact of host and viral factors related to iron metabolism
    Autorzy:
    Sikorska, K.
    Romanowski, T.
    Bielawski, K.P.
    Powiązania:
    https://bibliotekanauki.pl/articles/80838.pdf
    Data publikacji:
    2011
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    antiviral therapy
    chronic hepatitis C
    clinical consequence
    fibrosis
    hepatocellular carcinoma
    infection
    interferon
    iron metabolism
    iron overload
    liver cirrhosis
    liver disease
    liver transplantation
    pathogenesis
    ribavirin
    virus replication
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2011, 92, 1
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Sclerotherapy of esophageal varices in hemophilia patients with liver cirrhosis – a prospective, controlled clinical study
    Autorzy:
    Szczepanik, Andrzej B
    Pielaciński, Konrad
    Oses-Szczepanik, Anna M
    Huszcza, Sławomir
    Misiak, Andrzej
    Dąbrowski, Wojciech P
    Gajda, Sławomir
    Powiązania:
    https://bibliotekanauki.pl/articles/1392541.pdf
    Data publikacji:
    2018
    Wydawca:
    Index Copernicus International
    Tematy:
    hemophilia
    esophageal varices
    bleeding
    endoscopic sclerotherapy
    liver cirrhosis
    Opis:
    Introduction: Bleeding from esophageal varices is a serious clinical condition in hemophilia patients due to congenital deficiency or lack of clotting factors VIII (in hemophilia A) and IX (in hemophilia B), decreased clotting factor II, VII, IX, X synthesis in the course of chronic liver disease and hipersplenic thrombocytopenia. The aim of this study was to assess the efficacy and safety of endoscopic sclerotherapy in acute esophageal variceal bleeding and in secondary prophylaxis of hemorrhage. The aim was also to investigate the optimal activity of deficiency factors VIII or IX and duration of replacement therapy required to ensure proper hemostasis after sclerotherapy procedures. Material and methods: 22 hemophilia patients (A-19, B-4) with coexistent liver cirrhosis and active esophageal variceal bleeding treated with endoscopic sclerotherapy were subjected to prospective analysis. The patients who survived were qualified to repeated sclerotherapy procedures every 3 weeks within secondary prophylaxis of bleeding (investigated group). A 3-day substitution therapy enhanced the infusion of the deficient or lacking factor in doses allowing to reach 80-100% of normal value activity of factor VIII on the 1st day and 60-80% in the next two days. The desired activity of factor IX was 60-80% and 40-60% respectively. The control group consisted of 20 non-hemophiliac patients with liver cirrhosis comparable in terms of age, sex, stage of advancement of liver cirrhosis, who underwent the same medical proceedings as the investigated group. Results: Active esophageal bleeding was stopped in 21 of 22 (95%) hemophilia patients. Complications were observed in 3 patients; 2 patients died. The rate of hemostasis, complications and deaths in the control group were comparable and no statistical differences were found. In hemophilia patients subjected to secondary prophylaxis of hemorrhage, in 18 of 20 (80%), complete eradication of esophageal varices was achieved after 4 to 7 sclerotherapy procedures in 1 patient (average 5.4). Recurrent bleeding was observed in 15% of patients, complication in 20%; 1 patient died. Time lapse from bleeding to eradication was 12-21 weeks (average 15.2). In the control group the rate of variceal eradication, complication and deaths was comparable and no statistical differences were found. The usage of factor VIII concentrates was as follows: in hemophilia A, in a severe form - 80.9 U/kg b.w./day, in hemophilia A in a severe form with an inhibitor <5 BU – 95.2 U/kg b.w./day, in mild form – 64.2 U/kg b.w./day and in severe hemophilia B – 91.6 U/kg b.w./day. Conclusions: Sclerotherapy is an effective method in the management of esophageal variceal bleeding in hemophilia patients. It is also effective for total eradication of varices when applied as a secondary prophylaxis of hemorrhage. In our opinion, a 3-day replacement therapy at the applied doses is sufficient to ensure hemostasis and avoid bleeding complications.
    Źródło:
    Polish Journal of Surgery; 2018, 90, 1; 29-34
    0032-373X
    2299-2847
    Pojawia się w:
    Polish Journal of Surgery
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Severe gynaecomastia associated with spironolactone treatment in a patient with decompensated alcoholic liver cirrhosis - case report
    Autorzy:
    Schab, K.
    Prystupa, A.
    Mulawka, D.
    Mulawka, P.
    Powiązania:
    https://bibliotekanauki.pl/articles/3042.pdf
    Data publikacji:
    2015
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    gynaecomastia
    spironolactone
    treatment
    patient
    alcoholic disease
    liver cirrhosis
    Opis:
    Gynaecomastia is uni- or bilateral breast enlargement in males associated with benign hyperplasia of the glandular, fibrous and adipose tissue resulting from oestrogen-androgen imbalance. Asymptomatic gynaecomastia is a common finding in healthy male adults and does not have to be treated, while symptomatic gynaecomastia might be the symptoma of many pathological conditions and requires meticulous diagnosis and therapeutic management. The commonest causes of gynaecomastia in the Polish population include liver cirrhosis and drugs used to treat its complications. The current study presents the case of severe painless gynaecomastia in a patient with decompensated alcoholic liver cirrhosis, treated with spironolactone because of ascites. Breast enlargement assessed a IIb according to the Simon’s Scale or III according to the Cordova-Moschella classification, developed slowly over the two-year period of low-dose spironolactone therapy The course and dynamics of disease are described and the main mechanisms leading to its development discussed. The importance of effective treatment of patients with severe gynecomastia is emphasized as the disease may result in significant psychosocial problems.
    Źródło:
    Journal of Pre-Clinical and Clinical Research; 2015, 09, 1
    1898-2395
    Pojawia się w:
    Journal of Pre-Clinical and Clinical Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Relationships between serum selenium and zinc concentrations versus profibrotic and proangiogenic cytokines (FGF-19 and endoglin) in patients with alcoholic liver cirrhosis
    Autorzy:
    Prystupa, Andrzej
    Kiciński, Paweł
    Luchowska-Kocot, Dorota
    Błażewicz, Anna
    Kurys-Denis, Ewa
    Niedziałek, Jarosław
    Sak, Jarosław
    Panasiuk, Lech
    Powiązania:
    https://bibliotekanauki.pl/articles/990858.pdf
    Data publikacji:
    2017
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    liver cirrhosis
    alcohol
    selenium
    zinc
    fibroblast growth factor-19
    endoglin
    Opis:
    Introduction and objective. Liver cirrhosis is a disease involving the liver parenchyma, which is characterised by fibrosis. and impaired architectonics of the parenchyma with regenerative nodules. The aim of the study was to determine the relationship between stage of alcoholic liver cirrhosis, concentrations of selenium, zinc and profibrotic and proangiogenic cytokines (FGF-19, ENG). Materials and method. The study included 99 patients with alcoholic cirrhosis and 20 healthy subjects. Ion chromatography with UV/VIS detection was used for determination of zinc ions in the previously mineralized serum samples. The measurements of selenium were performed with the ContrAA700 high-resolution continuum source graphite tube atomic absorption spectrometer. ELISA was used to determine concentration of FGF-19 and ENG in serum samples. Results. Concentrations of zinc and selenium were significantly decreased in cirrhotic patients (p<0.001 for both). The highest concentration of FGF-19 was found in Child-Pugh stage C liver cirrhosis patients (806.9±650.3 pg/ml), and was significantly higher than observed in controls (p=0.005) and stage A patients (compensated cirrhosis) (p=0.02). The highest concentration of ENG was demonstrated in the control group (3.24±148 ng/ml) while the lowest in patients with decompensated cirrhosis (7.32±5.39 ng/ml and 7.92±4.18 ng/ml for stage B and C; p=0.03 and p=0.02, respectively). The use of the multiple-variable model demonstrated that the independent factors affecting the concentration of ENG were the concentration of bilirubin (p=0.02), INR (p=0.01) and duration of alcohol abuse (p=0.02). The independent determinants of FGF-19 concentrations were found to be the stage (severity) of liver cirrhosis (p=0.04) and INR (p=0.03). Conclusions. Concentrations of zinc and selenium in serum of patients with alcoholic liver cirrhosis are not independently related to concentrations of FGF-19 and ENG.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2017, 24, 3
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Glutathione and GSH-dependent enzymes in patients with liver cirrhosis and hepatocellular carcinoma
    Autorzy:
    Czeczot, Hanna
    Ścibior, Dorota
    Skrzycki, Michał
    Podsiad, Małgorzata
    Powiązania:
    https://bibliotekanauki.pl/articles/1041298.pdf
    Data publikacji:
    2006
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    malondialdehyde
    glutathione S-transferase
    glutathione reductase
    liver cirrhosis
    glutathione peroxidase
    glutathione
    hepatocellular carcinoma
    Opis:
    We investigated glutathione level, activities of selenium independent GSH peroxidase, selenium dependent GSH peroxidase, GSH S-transferase, GSH reductase and the rate of lipid peroxidation expressed as the level of malondialdehyde in liver tissues obtained from patients diagnosed with cirrhosis or hepatocellular carcinoma. GSH level was found to be lower in malignant tissues compared to adjacent normal tissues and it was higher in cancer than in cirrhotic tissue. Non-Se-GSH-Px activity was lower in cancer tissue compared with adjacent normal liver or cirrhotic tissue, while Se-GSH-Px activity in cancer was found to be similar to its activity in cirrhotic tissue and lower compared to control tissue. An increase in GST activity was observed in cirrhotic tissue compared with cancer tissue, whereas the GST activity in cancer was lower than in adjacent normal tissue. The activity of GSH-R was similar in cirrhotic and cancer tissues, but higher in cancer tissue compared to control liver tissue. An increased level of MDA was found in cancer tissue in comparison with control tissue, besides its level was higher in cancer tissue than in cirrhotic tissue. Our results show that the antioxidant system of cirrhosis and hepatocellular carcinoma is severely impaired. This is associated with changes of glutathione level and activities of GSH-dependent enzymes in liver tissue. GSH and enzymes cooperating with it are important factors in the process of liver diseases development.
    Źródło:
    Acta Biochimica Polonica; 2006, 53, 1; 237-242
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    PDGF-BB homodimer serum level – a good indicator of the severity of alcoholic liver cirrhosis
    Autorzy:
    Kurys-Denis, E.
    Prystupa, A.
    Luchowska-Kocot, D.
    Krupski, W.
    Bis-Wencel, H.
    Panasiuk, L.
    Powiązania:
    https://bibliotekanauki.pl/articles/2085441.pdf
    Data publikacji:
    2020
    Wydawca:
    Instytut Medycyny Wsi
    Tematy:
    alcohol
    liver cirrhosis
    Child-Pugh score
    platelet derived growth factor AA
    platelet growth factor AB
    platelet derived
    growth factor BB
    Opis:
    Introduction. Liver cirrhosis is a chronic disease in which progressive fibrosis is noted. This process leads to changed architectonics of the liver parenchyma and the appearance of regenerative nodules, all of which are caused by pathological activation of the hepatic stellate cells. This process is enhanced on a molecular level by many cytokines, with platelet-derived growth factors (PDGFs) playing the key role. Objective. The aim of the study was to assess serum concentrations of PDGFs active biodymers (PDGF-AA, PDGF-BB and PDGF-AB) in patients with alcoholic liver cirrhosis, and to correlate them with the stage of disease. Materials and method. 64 patients with alcoholic cirrhosis and a control group of 16 healthy individuals were analysed. Liver cirrhosis was determined based on clinical image, history of the patients’ alcohol consumption, laboratory findings and abdominal ultrasonography. The serum PDGF-AA, PDGF-BB and PDGF-AB concentrations were determined using ELISA kits. Results. Serum concentration of PDGF-AA and PDGF-BB homodimers increases in patients with alcoholic liver cirrhosis (p=0.034 and p<0.0001, respectively), unlike the serum concentration of PDGF-AB heterodimer (p>0.05). When the stage of the disease increases, the concentrations of PDGF-AA and PGFD-BB in blood also oncrease. Furthermore, the serum level of both PDGF-AA and PDGF-BB correlates significantly with the severity of alcoholic liver cirrhosis (measured by Pugh-Child’s scale), the correlation being stronger in the case of PDGF-BB levels than PDGF-AA (R=0.28; p=0.027 and R=0.26; p=0.038, respectively). Conclusions. The plasma levels of PDGF-AA and -BB may be indicators of alcohol-induced liver fibrosis process, and might be considered as future possible treatment targets, with PDGF-BB levels being an even better indicator than PDGF-AA levels.
    Źródło:
    Annals of Agricultural and Environmental Medicine; 2020, 27, 1; 80-85
    1232-1966
    Pojawia się w:
    Annals of Agricultural and Environmental Medicine
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Ocena częstości występowania patologii w obrębie górnego odcinka przewodu pokarmowego u chorych ze zdekompensowaną marskością wątroby i żylakami przełyku
    Evaluation of prevalence of pathology in upper gastrointestinal tract in patients with decompensated cirrhosis and esophageal varices
    Autorzy:
    Kowalski, Marek Konrad
    Cok, Aleksandra
    Domżał-Magrowska, Danuta
    Gąsiorowska, Anita
    Powiązania:
    https://bibliotekanauki.pl/articles/1035106.pdf
    Data publikacji:
    2014
    Wydawca:
    Śląski Uniwersytet Medyczny w Katowicach
    Tematy:
    żylaki przełyku
    ciemnosine znamiona
    marskość wątroby
    gastropatia wrotna
    żylaki dna żołądka
    klasyfikacja
    omed
    krwawienie z górnego odcinka przewodu pokarmowego
    esophageal varices
    red spots
    liver cirrhosis
    portal gastropathy
    gastric varices
    omed classification
    upper
    gastrointestinal bleeding
    Opis:
    INTRODUCTION Esophageal varices are formed as a result of increased blood pressure in the portal vein. They usually develop as a result of liver cirrhosis. Liver cirrhosis may be accompanied by other endoscopic changes in the mucous mem-branes of the upper gastrointestinal tract e.g. portal gastropathy, gastric varices, as well as gastritis. AIM OF THE STUDY The aim of the paper is to evaluate the prevalence of other pathologies in upper gastrointestinal endoscopy in patients with esophageal varices and to assess the endoscopic features which indicate the risk of variceal bleeding. MATERIALS AND METHODS An analysis of 300 records of patients with endoscopic esophageal varices was conducted . Endoscopy was performed in the years 2006–2012 in the Department of Digestive Tract Diseases, Medical University of Lodz. OMED classification was used to evaluate the severity of esophageal varices. RESULTS In this research during endoscopy, esophageal varices in OMED stage I were found in 25.4% of cases, in stage II 39.3% of cases, stage III 27% of cases, and in OMED stage IV in 8.3% of cases. The mean age was 58 years (±12.6 SD), 43% of the study group were women. The most common upper GI pathology was gastritis (36.3%). Furthermore, portal gastropathy was found in 34% of cases, gastric varices in 14.3% of cases and gastric polips in 7.7% of cases. Gastric varices occurred more frequently in patients with esophageal varices in OMED stage IV (40%), than in the other groups (12%). In this group, gastric polyps were also more frequently observed than in the others (7.3%). The incidence of red spots on the mucosa of the esophagus was increased due to the severity of esophageal varices. Red spots are known to be a risk marker of bleeding. Furthermore, esophageal mucosal ulceration was observed in 4.3% of cases and oesophagitis in 1.3% of cases. CONCLUSIONS The analysis found that in patients with esophageal varices, other changes in upper gastrointestinal endoscopy were often accompanied. The most commonly reported pathologies were gastritis and portal gastropathy. The incidence of gastric fundus varices, gastric polyps or endoscopic signs of bleeding risk, was increased due to the severity of esophageal varices.
    WSTĘP Żylaki przełyku powstają w wyniku wzrostu ciśnienia w układzie wrotnym. Do ich rozwoju dochodzi głównie w przebiegu marskości wątroby, której mogą towarzyszyć także inne zmiany endoskopowe w obrębie błony śluzowej górnego odcinka przewodu pokarmowego (GOPP), takie m.in. jak: gastropatia wrotna, żylaki dna żołądka, zapalenie błony śluzowej żołądka. CEL PRACY Celem pracy jest ocena częstości współwystępowania innych patologii w endoskopii GOPP u chorych z żylakami przełyku, a także ocena cech endoskopowych żylaków wskazujących na ryzyko krwawienia. MATERIAŁY I METODY Dokonano analizy 300 opisów badań endoskopowych pacjentów z żylakami przełyku. Badania przeprowadzono w latach 2006–2012 w Klinice Chorób Przewodu Pokarmowego UM w Łodzi. Do oceny stopnia zaawansowania żylaków przełyku wykorzystano klasyfikację OMED. WYNIKI W przeprowadzonych badaniach endoskopowych żylaki w stopniu I według OMED stwierdzono w 25,4% przypadków, w stopniu II w 39,3%, w stopniu III w 27%, zaś w stopniu IV w 8,3%. Średni wiek badanych wynosił 58 lat (±12,6 SD), 43% grupy badanej stanowiły kobiety. Najczęstszą współwystępującą patologią GOPP było zapalenie błony śluzowej żołądka (36,3%). Ponadto stwierdzono gastropatię wrotną (34% przypadków), żylaki dna żołądka (14,3%) i polipy żołądka (7,7%). Żylaki dna żołądka współwystępowały najczęściej u pacjentów z żylakami przełyku w stopniu IV OMED (n = 40%), istotnie częściej niż w pozostałych grupach (n = 12%). W grupie tej obserwowano również częstsze niż u pozostałych (7,3%) występowanie polipów żołądka (12%). Wraz ze wzrostem zaawansowania żylaków przełyku według skali OMED obserwowano częstsze występowanie ciemnosinych znamion na błonie śluzowej przełyku, czyli endoskopowych markerów ryzyka krwawienia. Ponadto w obrębie błony śluzowej przełyku obserwowano owrzodzenia (4,3%) oraz zapalenie błony śluzowej przełyku (1,3%). WNIOSKI Przeprowadzona analiza wykazała częste współistnienie zmian endoskopowych GOPP u pacjentów z rozpoznanymi żylakami przełyku, najczęściej były to zapalenie błony śluzowej żołądka oraz gastropatia wrotna. Wzrostowi stopnia zaawansowania żylaków przełyku towarzyszyło częstsze występowanie żylaków dna żołądka, polipów żołądka i endoskopowych objawów ryzyka krwawienia.
    Źródło:
    Annales Academiae Medicae Silesiensis; 2014, 68, 1; 16-22
    1734-025X
    Pojawia się w:
    Annales Academiae Medicae Silesiensis
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-12 z 12

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies