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Tytuł:
Processes of lipids peroxidation and antioxidant activity of the oral fluid for patients with acute odontogenic osteomielitis complicated with phlegmons of different location
Autorzy:
Pohodenko-Chudakova, I. O.
Kabanova, A. A.
Powiązania:
https://bibliotekanauki.pl/articles/285451.pdf
Data publikacji:
2011
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
phlegmons
lipid peroxidation
biomaterials
Źródło:
Engineering of Biomaterials; 2011, 14, no. 109-111 spec. iss.; 6-9
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The reactions of hypochlorous acid, the reactive oxygen species produced by myeloperoxidase, with lipids.
Autorzy:
Spickett, Corinne
Jerlich, Andreas
Panasenko, Oleg
Arnhold, Juergen
Pitt, Andrew
Stelmaszyńska, Teresa
Schaur, R.
Powiązania:
https://bibliotekanauki.pl/articles/1044206.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
lipid chlorohydrins
lipids
unsaturated fatty acids
hypochlorous acid
lipid peroxidation
low density lipoprotein
Opis:
Myeloperoxidase (MPO), an abundant enzyme in phagocytes, has been implicated in the pathogenesis of various inflammatory diseases including atherosclerosis. The major oxidant produced by MPO, hypochlorous acid (HOCl), is able to modify a great variety of biomolecules by chlorination and/or oxidation. In this paper the reactions of lipids (preferentially unsaturated fatty acids and cholesterol) with either reagent HOCl or HOCl generated by the MPO-hydrogen peroxide-chloride system are reviewed. One of the major issues has been whether the reaction of HOCl with lipids of low density lipoprotein (LDL) yields predominantly chlorohydrins or lipid hydroperoxides. Electrospray mass spectrometry provided direct evidence that chlorohydrins rather than peroxides are the major products of HOCl- or MPO-treated LDL phosphatidylcholines. Nevertheless lipid peroxidation is a possible alternative reaction of HOCl with polyunsaturated fatty acids if an additional radical source such as pre-formed lipid hydroperoxides is available. In phospholipids carrying a primary amino group such as phosphatidylethanolamine chloramines are the preferred products compared to chlorohydrins. Cholesterol can be converted by HOCl to great variety of oxysterols besides three isomers of chlorohydrins. For the situation in vivo it appears that the type of reaction occurring between HOCl and lipids would very much depend on the circumstances, e.g. the pH and the presence of radical initiators. The biological effects of lipid chlorohydrins are not yet well understood. It has been shown that chlorohydrins of both unsaturated fatty acids as well as of cholesterol may cause lysis of target cells, possibly by disruption of membrane structures.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 889-899
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipid radicals: Properties and detection by spin trapping.
Autorzy:
Stolze, Klaus
Udilova, Natascha
Nohl, Hans
Powiązania:
https://bibliotekanauki.pl/articles/1044212.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
DEPMPO
spin trapping
linoleic acid hydroperoxide
free radicals
lipid peroxidation
ESR
lipid radicals
Opis:
Unsaturated lipids are rapidly oxidized to toxic products such as lipid hydroperoxides, especially when transition metals such as iron or copper are present. In a Fenton-type reaction Fe2+ converts lipid hydroperoxides to the very short-lived lipid alkoxyl radicals. The reaction was started upon the addition of Fe2+ to an aqueous linoleic acid hydroperoxide (LOOH) emulsion and the spin trap in the absence of oxygen. Even when high concentrations of spin traps were added to the incubation mixture, only secondary radical adducts were detected, probably due to the rapid rearrangement of the primary alkoxyl radicals. With the commercially available nitroso spin trap MNP we observed a slightly immobilized ESR spectrum with only one hydrogen splitting, indicating the trapping of a methinyl fragment of a lipid radical. With DMPO or 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO) adducts were detected with carbon-centered lipid radical, with acyl radical, and with the hydroxyl radical. We also synthesized lipophilic derivatives of the spin trap DEPMPO in order to detect lipid radical species generated in the lipid phase. With all spin traps studied a lipid-derived carbon-centered radical was obtained in the anaerobic incubation system Fe2+/LOOH indicating the trapping of a lipid radical, possibly generated as a secondary reaction product of the primary lipid alkoxyl radical formed. Under aerobic conditions an SOD-insensitive oxygen-centered radical adduct was formed with DEPMPO and its lipophilic derivatives. The observed ESR parameters were similar to those of alkoxyl radical adducts, which were independently synthesized in model experiments using Fe3+-catalyzed nucleophilic addition of methanol or t-butanol to the respective spin trap.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 923-930
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Prognostic efficiency of inflammatory complications development of dental implantation based on indicators of lipid peroxidation (LPO) of oral fluid
Autorzy:
Pohodenko-Chudakova, I. O.
Karsyuk, Y. V.
Powiązania:
https://bibliotekanauki.pl/articles/284842.pdf
Data publikacji:
2017
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
dental implants
complications
lipid peroxidation
Opis:
The frequency of complications of dental implantation at the present stage varies from 6% to 23%, what determined the relevance of this examination. The aim of this work is to determine the predictive effectiveness of the development of inflammatory complications of dental implantation on the basis of indicators of lipid peroxidation (POL) of the oral fluid (level of malondialdehyde (MDA) and the activity level of superoxide dismutase (SOD)). We examined 49 patients 25-59 years old which had no traumas, operations and diseases requiring medical rehabilitation, inflammatory disease in the maxillofacial area and the gastrointestinal tract, as well as other factors that can affect qualitative and quantitative content of the oral fluid. These patients underwent delayed dental implantation (one implant in one segment of the jaw). The POL indices were determined twice: before operation of dental implantation and 3 days after operation. The effectiveness of the proposed method was determined in accordance to the clinical and economic studies requirements. Prognostic efficiency in accordance with the procedure of conducting clinical and economic examinations on the basis of MDA level was 78%, and based on the level of SOD activity – 76%, which classifies it as high and allow to reduce the number of complications and diagnostic mistakes including in the planning and execution of invasive procedures associated with the installation of dental implants.
Źródło:
Engineering of Biomaterials; 2017, 20, no. 143 spec. iss.; 13
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Arabidopsis lipocalins AtCHL and AtTIL have overlapping functions essential for lipid protection and seed longevity
Autorzy:
Simona, B.
Powiązania:
https://bibliotekanauki.pl/articles/80754.pdf
Data publikacji:
2013
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
conference
Arabidopsis
lipocalin
oxidative stress
photooxidative stress
lipid peroxidation
photosensitivity
polyunsaturated lipid
seed longevity
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2013, 94, 2
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Species- and substrate-specific stimulation of human plasma paraoxonase 1 (PON1) activity by high chloride concentration.
Autorzy:
Bełtowski, Jerzy
Wójcicka, Grażyna
Marciniak, Andrzej
Powiązania:
https://bibliotekanauki.pl/articles/1043697.pdf
Data publikacji:
2002
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
paraoxonase
arylesterase
lipid peroxidation
oxidative stress
Opis:
Paraoxonase 1 (PON1), contained in plasma high-density lipoproteins, plays an important role in the protection of plasma lipoproteins and cell membranes from oxidative damage. Previous studies indicate that human PON1 is stimulated by high NaCl concentrations. The aim of this study was to characterize in more detail the effect of salts on serum PON1. Paraoxon-hydrolyzing activity of human serum was stimulated by 81.6% following the addition of 1 M NaCl. The effect of NaCl was dose-dependent between 0.5 and 2 M. PON1 activity toward phenyl acetate was reduced by 1 M NaCl by 55.2%. Both the paraoxon- and phenyl acetate-hydrolysing activity was slightly lower in heparinized plasma than in serum, but NaCl had similar stimulatory and inhibitory effects on these activities, respectively. In rat, rabbit, and mouse, NaCl reduced PON1 activity. KCl had a similar effect on human PON1 as NaCl. Sodium nitrite also stimulated human PON1 but much less effectively than chloride salts. In contrast, sucrose, sodium acetate and sodium lactate had no significant effect. NaBr was a less effective PON1 activator than NaCl, whereas the effect of NaJ was non-significant. The activity of human PON1 toward homogentisic acid lactone and γ-decanolactone was unaltered by NaCl. These data indicate that: 1) high concentrations of chlorides stimulate human PON1 activity toward paraoxon but not other substrates, 2) PON1 is inhibited by Cl- in other mammalian species, 3) the potency of human PON1 activation by halogene salts increases with decreasing atomic mass of the halide anion.
Źródło:
Acta Biochimica Polonica; 2002, 49, 4; 927-936
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tough sprouting - impact of cadmium on physiological state and germination rate of soybean seeds
Autorzy:
Chmielowska-Bak, J.
Holubek, R.
Frontasyeva, M.
Zinicovscala, I.
Isidogru, S.
Deckert, J.
Powiązania:
https://bibliotekanauki.pl/articles/2130694.pdf
Data publikacji:
2020
Wydawca:
Polskie Towarzystwo Botaniczne
Tematy:
metal stress
antioxidants
cell viability
lipid peroxidation
Opis:
Seed germination is the earliest process in plant development and is crucial for further plant growth and fitness. The process is regulated by various internal and external factors, including soil pollutants such as nonessential metals. In the present study, we examined in detail the impact of short-term imbibition in Cd solutions at several concentrations (5, 10, and 25 mg/L) on germination rate and physiological state of soybean seeds. The results showed that although Cd was readily absorbed by the seeds, the metal had no effect on seeds cell viability, oxidative stress intensity, or germination percentage. In contrast, imbibition in Cd solution led to slight reduction in antioxidant capacity of seeds. Seedlings grown from seeds pretreated with metal showed no differences in growth in relation to the control. Taken together, the results indicate that soybean seeds are relatively tolerant even to high Cd concentration (up to 25 mg/L).
Źródło:
Acta Societatis Botanicorum Poloniae; 2020, 89, 2
0001-6977
2083-9480
Pojawia się w:
Acta Societatis Botanicorum Poloniae
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Spectral fingerprinting revealed modulation of plant secondary metabolites in providing abiotic stress tolerance to invasive alien plants Lantana camara (L.), Parthenium hysterophorous (L.), Ricinus communis (L.), and Ageratum conyzoides (L.) (plant metabolites in stress tolerance to invasive plants)
Autorzy:
Sharma, A.D.
Kaur, J.
Chand, T.S.P.
Powiązania:
https://bibliotekanauki.pl/articles/2096781.pdf
Data publikacji:
2021
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
chemical fingerprinting
invasiveness
lipid peroxidation
secondary metabolites
Opis:
Invasive alien species are non-native plant species that displace native species and pose adverse effects to environment, ecosystem, economy, and human health by diminishing the growth of native plants and by exhibiting higher stress tolerance. In our present study, four invasive alien species, namely Lantana camara, Parthenium hysterophorous, Ricinus communis, and Ageratum conyzoides, were studied from different locations. Plants growing under natural environmental conditions were sampled at random in the vicinity of Jalandhar. To gain insights into the biochemical basis of invasiveness of these plants, the samples were subjected to chemical fingerprinting by using UV-Vis, fluorescent, and Fourier transform-infrared (FT-IR) techniques under natural abiotic stress conditions (moderate and hot conditions). Indices of oxidative stress, such as malondialdehyde (MDA), were also studied. MDA levels were enhanced under hot conditions. Elevated peaks (major and minor) were observed in UV fingerprinting during adverse abiotic conditions. Fluorescent spectroscopy also validated the enhanced levels of secondary metabolites. FT-IR spectroscopy confirmed the presence of alkaloids and phenolics during stress conditions. Peaks were identified as rutin, vanillic acid, ascorbic acid, and glutathione reduced. The obtained results showed that under stressful conditions, the studied plants may produce an increased level of metabolites that might play a role in minimizing the oxidative stress faced by these plants. It was concluded that the studied plants, namely P. hysterophorus, L. camara, R. communis, and A. conyzoides, have the potential to cope with abiotic stress such as high temperature, which could be the reason for their invasiveness and vast adaptability.
Źródło:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2021, 102, 3; 307-319
0860-7796
Pojawia się w:
BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line
Autorzy:
Łazarenkow, Andrzej
Michalska, Marta
Gorąca, Anna
Mirowski, Marek
Nawrot-Modranka, Jolanta
Piechota-Polanczyk, Aleksandra
Powiązania:
https://bibliotekanauki.pl/articles/1039590.pdf
Data publikacji:
2013
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hydrazone
chromone
phosphorohydrazone
HL-60
lipid peroxidation
bFGF
Opis:
Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).
Źródło:
Acta Biochimica Polonica; 2013, 60, 2; 259-262
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of electromagnetic field (1800 MHz) on lipid peroxidation in brain, blood, liver and kidney in rats
Autorzy:
Bodera, Paweł
Stankiewicz, Wanda
Antkowiak, Bożena
Paluch, Małgorzata
Kieliszek, Jarosław
Sobiech, Jaromir
Niemcewicz, Marcin
Powiązania:
https://bibliotekanauki.pl/articles/2177234.pdf
Data publikacji:
2015-06-09
Wydawca:
Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
Tematy:
electromagnetic field
lipid peroxidation
malondialdehyde
rats
analgesics
tramadol
Opis:
Objectives The aim of this study is the evaluation of the influence of repeated (5 times for 15 min) exposure to electromagnetic field (EMF) of 1800 MHz frequency on tissue lipid peroxidation (LPO) both in normal and inflammatory state, combined with analgesic treatment. Material and Methods The concentration of malondialdehyde (MDA) as the end-product of the lipid peroxidation (LPO) was estimated in blood, liver, kidneys, and brain of Wistar rats, both healthy and those with complete Freund’s adjuvant (CFA)-induced persistent paw inflammation. Results The slightly elevated levels of the MDA in blood, kidney, and brain were observed among healthy rats in electromagnetic field (EMF)-exposed groups, treated with tramadol (TRAM/EMF and exposed to the EMF). The malondialdehyde remained at the same level in the liver in all investigated groups: the control group (CON), the exposed group (EMF), treated with tramadol (TRAM) as well as exposed to and treated with tramadol (TRAM/EMF). In the group of animals treated with the complete Freund’s adjuvant (CFA) we also observed slightly increased values of the MDA in the case of the control group (CON) and the exposed groups (EMF and TRAM/EMF). The MDA values concerning kidneys remained at the same levels in the control, exposed, and not-exposed group treated with tramadol. Results for healthy rats and animals with inflammation did not differ significantly. Conclusions The electromagnetic field exposure (EMF), applied in the repeated manner together with opioid drug tramadol (TRAM), slightly enhanced lipid peroxidation level in brain, blood, and kidneys.
Źródło:
International Journal of Occupational Medicine and Environmental Health; 2015, 28, 4; 751-759
1232-1087
1896-494X
Pojawia się w:
International Journal of Occupational Medicine and Environmental Health
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Pain and mobility improvement and MDA plasma levels in degenerative osteoarthritis, low back pain, and rheumatoid arthritis after infrared A-irradiation
Autorzy:
Siems, Werner
Bresgen, Nikolaus
Brenke, Rainer
Siems, Renate
Kitzing, Manfred
Harting, Heike
Eckl, Peter
Powiązania:
https://bibliotekanauki.pl/articles/1040373.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
rheumatoid arthritis
infrared
malondialdehyde (MDA)
lipid peroxidation
pain
osteoarthritis
Opis:
Infrared (IR)-A irradiation can be useful in back and musculoskeletal pain therapy. In this study joint and vertebral column pain and mobility were measured during two weeks of IR-A irradiation treatment of patients suffering from degenerative osteoarthritis of hip and knee, low back pain, or rheumatoid arthritis. Additionally, before and after IR-A treatment MDA serum levels were measured to check if MDA variations accompany changes in pain intensity and mobility. Two-hundred and seven patients were divided into verum groups getting IR-irradiation, placebo groups getting visible, but not IR irradiation, and groups getting no irradiation. In osteoarthritis significant pain reduction according to Visual Analogue Scale and mobility improvements occurred in the verum group. Even though beneficial mean value changes occurred in the placebo group, the improvements in the placebo and No Irradiation groups were without statistical significance. In low back pain, pain and mobility improvements (by 35-40%) in the verum group were found, too. A delayed (2nd week) mobility improvement in rheumatoid arthritis was seen. However, pain relief was seen immediately. In patients suffering from low back pain or rheumatoid arthritis, the pain and mobility improvements were accompanied by significant changes of MDA serum levels. However, MDA appears not a sensitive biofactor for changes of the pain intensity in degenerative osteoarthritis. Nevertheless, unaffected or lowered MDA levels during intensive IR-A therapy argue against previous reports on free radical formation upon infrared. In conclusion, rapid beneficial effects of IR-A towards musculoskeletal pain and joint mobility loss were demonstrated.
Źródło:
Acta Biochimica Polonica; 2010, 57, 3; 313-319
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dynamics of estrogen-induced oxidative stress
Autorzy:
Kobiela, Jarek
Stefaniak, Tomasz
Krajewski, Jacek
Kalinska-Blach, Beata
Zurawa-Janicka, Dorota
Lachinski, Andrzej
Gackowski, Daniel
Olinski, Ryszard
Nowak, Jerzy
Knap, narcyz
Lipinska, Barbara
Sledzinski, Zbigniew
Wozniak, Michal
Powiązania:
https://bibliotekanauki.pl/articles/1041076.pdf
Data publikacji:
2007
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
8-oxodGuo
estradiol
protein oxidation
carcinogenesis
DNA damage
lipid peroxidation
Opis:
The objective of this study was to assess the dynamics of oxidative damage to cellular macromolecules such as proteins, lipids and DNA under conditions of oxidative stress triggering early stages of estrogen-dependent carcinogenesis. A rodent model of carcinogenesis was used. Syrian hamsters were sacrificed after 1, 3, 5 h and one month from the initial implantation of estradiol. Matching control groups were used. Kidneys as target organs for estradiol-mediated oxidative stress were excised and homogenized for biochemical assays. Subcellular fractions were isolated. Carbonyl groups (as a marker of protein oxidation) and lipid hydroxyperoxides were assessed. DNA was isolated and 8-oxodGuo was assessed. Electron paramagnetic resonance spectroscopy was used to confirm the results for lipid peroxidation. Exposition to estradiol in the rodent model leads to damage of macromolecules of the cell, including proteins and DNA, but not lipids. Proteins appear to be the primary target of the damage but are closely followed by DNA. It has previously been speculated that protein peroxides can increase DNA modifications. This time sequence was observed in our study. Nevertheless, the direct relation between protein and DNA damage still remains unsolved.
Źródło:
Acta Biochimica Polonica; 2007, 54, 2; 289-295
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ zastosowania seleninu sodu w eksperymentalnym modelu zatrucia glifosatem
The effect of sodium selenite treatment in an experimental model of acute glyphosphate poisoning
Autorzy:
Oliynyk, O.
Powiązania:
https://bibliotekanauki.pl/articles/2048939.pdf
Data publikacji:
2020
Wydawca:
Akademia Bialska Nauk Stosowanych im. Jana Pawła II w Białej Podlaskiej
Tematy:
lipid peroxidation
antioxidants
glyphosate poisoning
peroksydacja lipidów
antyoksydanty
zatrucie glifosatem
Opis:
Background. The aim of this study was to investigate the possibility of using sodium selenite as a treatment for acute glyphosate poisoning using the activity of the lipid peroxidation and antioxidant defence systems as a readout for efficacy. Material and methods. Experimental glyphosate poisoning and subsequent treatment using sodium selenite was performed in albino rats (105). Glyphosate was given in doses of 50, 100 and 130 mg/kg, and sodium selenite was administered at a dose of 2 μg/kg. The blood concentrations of lipid peroxidation markers including conjugates of diene andtrienoic and malondialdehyde were determined. The endogenous glutathione (reduced form) level and activities of catalase, superoxide dismutase and glutathione peroxidase in the serum were measured. Results. Glyphosate poisoning has been found to result in a significant increase in lipid peroxidation activity. For example, malonic dialdehyde demonstrates a 2.35 times increase at a glyphosate dose of 130 mg/kg. At the experimental glyphosate poisoning dose of 100 mg/kg the measurements of superoxide dismutase and glutathione peroxidase have been found to decrease 1.58 and 2.21 times, respectively. At a dose of 130 mg/kg, those values decreased 2.51 and 4.76 times, respectively, compared to untreated controls. Conclusions. The use of sodium selenite at a dose of 2 μg/kg after poisoning of white rats with glyphosate (at doses of 50, 100 and 130 mg/kg) normalizes the lipid peroxidation and antioxidant defence activities of the body.
Wprowadzenie. Celem niniejszej pracy było zbadanie możliwości zastosowania seleninu sodu w leczeniu ostrego zatrucia glifosatem wykorzystując aktywność peroksydacji lipidów oraz antyoksydacyjnych układów ochronnych jako wskaźnik skuteczności. Materiał i metody. 105 szczurów albinosów poddano eksperymentalnemu zatruciu glifosatem i leczeniu seleninem sodu. Glifosat został zastosowany w dawkach 50, 100 i 130 mg/kg. Selenin sodu podawano w dawce 2 μg/kg. Oznaczono stężenie markerów peroksydacji lipidów we krwi: koniugatów dien i trienoicznych oraz dwualdehydu maleinowego. Zbadano poziom endogennego glutationu (w zredukowanej formie) oraz aktywność katalazy, dysmutazy ponadtlenkowej i peroksydazy glutationowej w surowicy krwi. Wyniki. Stwierdzono, że zatrucie glifosatem powoduje znaczny wzrost aktywności peroksydacji lipidów. Przykładowo, poziom dwualdehydu maleinowego wzrósł 2,35 razy w przypadku dawki glifosatu wynoszącej 130 mg/kg. Stwierdzono również, że wskaźniki dysmutazy ponadtlenkowej i peroksydazy glutationowej zmniejszają się odpowiednio 1,58 i 2,21 w eksperymentalnym zatruciu glifosatem w dawce 100 mg/kg. Zaobserwowane wartości zmniejszyły się 2,51 i 4,76 razy podczas zastosowania dawki 130 mg/kg w porównaniu z grupą kontrolną zdrowych zwierząt. Wnioski. Zastosowanie seleninu sodu w dawce 2 μg/kg, aby przeciwdziałać zatruciu glifosatem w dawkach 50, 100 i 130 mg/kg u szczurów albinosów, normalizuje peroksydację lipidów i czynności obrony antyoksydacyjnej organizmu.
Źródło:
Health Problems of Civilization; 2020, 14, 2; 136-140
2353-6942
2354-0265
Pojawia się w:
Health Problems of Civilization
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells
Autorzy:
Radu, Mihaela
Munteanu, Maria
Petrache, Sorina
Serban, Andreea
Dinu, Diana
Hermenean, Anca
Sima, Cornelia
Dinischiotu, Anca
Powiązania:
https://bibliotekanauki.pl/articles/1040384.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
MRC-5 cells
antioxidant enzymes
glutathione
lipid peroxidation
hematite nanoparticles
Opis:
Particles generated from numerous anthropogenic and/or natural sources, such as crystalline α-Fe2O3 nanoparticles, have the potential to damage lung cells. In our study we investigated the effects of these nanoparticles (12.5 µg/ml) on lipid peroxidation and the antioxidative system in MRC-5 lung fibroblast cells following exposure for 24, 48 or 72h. Exposure to α-Fe2O3 nanoparticles increased lipid peroxidation by 81%, 189% and 110% after 24, 48 and 72h, respectively. Conversely, the reduced glutathione concentration decreased by 23.2% and 51.4% after 48 and 72h of treatment, respectively. In addition, an augmentation of the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione transferase and glutathione reductase within the interval between 48-72h was noticed. Taking into account that the reduced glutathione level decreased and the malondialdehyde level, a lipid peroxidation product, remained highly increased up to 72h of exposure, it would appear that the MRC-5 antioxidant defense mechanisms did not efficiently counteract the oxidative stress induced by exposure to hematite nanoparticles.
Źródło:
Acta Biochimica Polonica; 2010, 57, 3; 355-360
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Lipid peroxidation product 4-hydroxynonenal as factor of oxidative homeostasis supporting bone regeneration with bioactive glasses
Autorzy:
Mrakovcic, Lidija
Wildburger, Renate
Jaganjac, Morana
Cindric, Marina
Cipak, Ana
Borovic-Sunjic, Suzana
Waeg, Georg
Milankovic, Andrea
Zarkovic, Neven
Powiązania:
https://bibliotekanauki.pl/articles/1040400.pdf
Data publikacji:
2010
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
bone regeneration
4-hydroxynonenal
bioactive glass
oxidative homeostasis
lipid peroxidation
Opis:
Bone regeneration is a process of vital importance since fractures of long bones and large joints have a highly deleterious impact on both, individuals and society. Numerous attempts have been undertaken to alleviate this severe medical and social problem by development of novel bioactive materials, among which bioactive glass is the most attractive because of its osteoconductive and osteostimulative properties. Since lipid peroxidation is an important component of systematic stress response in patients with traumatic brain injuries and bone fractures, studies have been undertaken of the molecular mechanisms of the involvement of 4-hydroxynonenal (HNE), an end product of lipid peroxidation, in cellular growth regulation. We found that HNE generated in bone cells grown in vitro on the surfaces of bioactive glasses 45S5 and 13-93. This raises an interesting possibility of combined action of HNE and ionic bioglass dissolution products in enhanced osteogenesis probably through a mitogen-activated protein kinase (MAPK) pathway. While the proposed mechanism still has to be elucidated, the finding of HNE generation on bioglass offers a new interpretation of the osteoinducting mechanisms of bioglass and suggests the possibility of tissue engineering based on manipulations of oxidative homeostasis.
Źródło:
Acta Biochimica Polonica; 2010, 57, 2; 173-178
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
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