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Wyszukujesz frazę "lipid membrane" wg kryterium: Temat


Wyświetlanie 1-3 z 3
Tytuł:
The dynamics of the surface layer of lipid membranes doped by vanadium complex : computer modeling and EPR studies
Autorzy:
Olchawa, R.
Man, D.
Pytel, B.
Powiązania:
https://bibliotekanauki.pl/articles/147585.pdf
Data publikacji:
2015
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
EPR probe
lipid membrane
membrane fluidity
Monte Carlo simulation
Opis:
Penetration of the liposome membranes doped with vanadium complex formed in the liquid-crystalline phase from egg yolk lecithin (EYL) by the TEMPO (2,2,6,6-tetramethylpiperidine-1-oxyl) spin probes has been investigated. The penetration process was followed by 360 hours at 24◦C, using the electron spin resonance (EPR) method. The spectroscopic parameter of the partition (F) of this probe indicated that a maximum rigidity of the membrane was at 3% concentration of the vanadium complex. Computer simulations showed that the increase in the rigidity of the membrane corresponds to the closure of gaps in the surface layer of the membrane, and indicates the essential role of the membrane surface in transport processes.
Źródło:
Nukleonika; 2015, 60, No. 3, part 1; 395-398
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Molecular modelling of membrane activity of amphotericin B, a polyene macrolide antifungal antibiotic
Autorzy:
Baginski, Maciej
Sternal, Kamil
Czub, Jacek
Borowski, Edward
Powiązania:
https://bibliotekanauki.pl/articles/1041370.pdf
Data publikacji:
2005
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
antifungal agents
lipid membrane
cholesterol
amphotericin B
molecular modelling
ergosterol
Opis:
Amphotericin B (AmB) is a well known polyene macrolide antibiotic used to treat systemic fungal infections. Despite its toxicity AmB is still regarded as a life-saving drug. The lack of adequate knowledge of the AmB mechanism of action is a serious obstacle to efficient development of new less toxic derivatives. Complementary to various experimental approaches, computational chemistry methods were used to study AmB mechanism of action. A programme lasting for a decade, that was run by our group covered studies of: i) molecular properties of AmB and its membrane targets, ii) structure and properties of AmB membrane channels, and iii) interaction of AmB with the membrane.
Źródło:
Acta Biochimica Polonica; 2005, 52, 3; 655-658
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Wpływ anestetyków wziewnych na modelową błonę biologiczną
Influence of inhalation anesthetics on a model biological membrane
Autorzy:
Horochowska, Martyna
Cieślik-Boczula, Katarzyna
Rospenk, Maria
Powiązania:
https://bibliotekanauki.pl/articles/171702.pdf
Data publikacji:
2019
Wydawca:
Polskie Towarzystwo Chemiczne
Tematy:
anestetyki wziewne
anestezja
słabe oddziaływania międzycząsteczkowe
błona lipidowa
inhalation anesthetics
anesthesia
weak intermolecular interactions
lipid membrane
Opis:
General anesthesia is defined as impairment of the central nervous system (UON) caused by intravenous or volatile anesthetics. The state of loss of consciousness or even amnesia and the disappearance of perception into external stimuli is achieved by the use of a large group of chemical compounds. The use of nitrous oxide in 1844 revolutionized surgery and medicine at that time. From that moment, anesthesiology develops dynamically, allowing more and more complex procedures. Despite more than 170 years of history of anesthesia, understanding the mechanism of reversible loss of awareness and sensitivity to pain caused by the action of general anesthetics is one of the greatest challenges of modern pharmacology and neuroscience. Incredibly high diversity of anesthetics, including both noble gases and complex steroids, combined with human sensation makes the above problem extremely difficult to solve. The reversibility of the anesthesia phenomenon suggests that the analyzed phenomenon is based on disturbance of weak intermolecular interactions, such as hydrogen bond or van der Walls forces. Anesthetic molecules may bind directly to the hydrophobic region of protein, which causes its conformational changes or disturb ion channel activity by anesthetic-induced perturbations of lipid bilayers. The mechanism of anesthesia is thus very often attributed to both protein and lipid membrane targets. The influence of anesthetic molecules on biomolecular systems can be studied successfully using many different physico-chemical methods, such as, infrared, fluorescence or nuclear magnetic resonance spectroscopy. Vibrational circular dichroism as well as differential scanning calorimetry can also be used.
Źródło:
Wiadomości Chemiczne; 2019, 73, 3-4; 263-285
0043-5104
2300-0295
Pojawia się w:
Wiadomości Chemiczne
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-3 z 3

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