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    Wyświetlanie 1-3 z 3
    Tytuł:
    Wrazliwosc na mikonazol i itrakonazol szczepow grzybow z rodzaju Candida wyodrebnionych od pacjentow hospitalizowanych i leczonych w trybie ambulatoryjnym
    Susceptibility to miconazole and itraconazole of Candida strains isolated from hospitalized and outpatient clinic patients
    Autorzy:
    Kurnatowska, A.K.
    Kwasniewska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/840111.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    mikonazol
    wrazliwosc na leki
    itrakonazol
    Candida
    parazytologia lekarska
    leczenie szpitalne
    pacjenci
    leki przeciwgrzybicze
    szczepy grzybow
    leczenie ambulatoryjne
    grzybice
    Źródło:
    Annals of Parasitology; 2009, 55, 4; 415-423
    0043-5163
    Pojawia się w:
    Annals of Parasitology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wrażliwość na mikonazol i itrakonazol szczepów grzybów z rodzaju Candida wyodrębnionych od pacjentów hospitalizowanych i leczonych w trybie ambulatoryjnym
    Susceptibility to miconazole and itraconazole of Candida strains isolated from hospitalized and outpatient clinic patients
    Autorzy:
    Kurnatowska, A.K.
    Kwaśniewska, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/2143561.pdf
    Data publikacji:
    2009
    Wydawca:
    Polskie Towarzystwo Parazytologiczne
    Tematy:
    mikonazol
    wrazliwosc na leki
    itrakonazol
    Candida
    parazytologia lekarska
    leczenie szpitalne
    pacjenci
    leki przeciwgrzybicze
    szczepy grzybow
    leczenie ambulatoryjne
    grzybice
    Opis:
    It is known that fungi representing different genera and species can cause organ-limited or systemic infections after disrupting of the natural defense mechanisms in a human organism. The treatment of mycoses still encounters considerable difficulties. Therefore, in vitro assessment of the susceptibility of fungal strains to the antifungal agents now in use and to new drugs is needed more urgently than ever before. It should be emphasized that we treat the fungal susceptibility to antifungal drugs as a quantitative feature of the strain examined. The aim of the presently reported study was the evaluation of the antimycotic action of two azole compounds – miconazole and itraconazole (Janssen) against 205 Candida strains isolated from the various biological specimens of two groups of patients – hospitalized (group 1) and examined in outpatient clinic (group 2); differentiation of species and codes of these strains; analysis of dose-response curves and parameters of polygons of the azoles minimal inhibitory concentrations (MIC). The susceptibility to miconazole and itraconazole was estimated with the agar diffusion test on 3% Sabouraud’s agar – the method developed in our laboratory, using several different concentrations of the drug, which made the plotting of dose-response curves possible. The lowest concentration inhibiting the growth of fungal strain (MIC) was calculated using a transformed equation of rectilinear regression according to Kadłubowski. Species and fungal codes of isolated strains were evaluated according to the guidelines worked out in our department with the use of different media and biochemical tests (bioMérieux). Among 89 strains isolated from the hospitalized patients, six species of the genus Candida genus were found; one strain belonged to Trichosporon cutaneum species. The most frequently encountered species was Candida albicans (73%), which significantly dominated over C. tropicalis, C. parapsilosis, C. glabrata, C. lipolytica and C. famata. All strains from the second group of patients belonged to C. albicans species. In all C. albicans strains from both groups of patients, the most frequent assimilation code (2576174) was found. The miconazole MIC values for Candida strains isolated from the group 1 were characterized by a wide range of variation, from 0.0247mg/l to 6.826 mg/l, from group 2 – 0.0277 to 0.719 mg/l. The itraconazole MIC values were 0.011 to 2.813 mg/l, and 0.0103 to 0.718 mg/l, respectively. The analysis of mean values (x) of miconazole and itraconazole MICs and other parameters allowed us to find that the strains isolated from the patients of group 1 were significantly less susceptible to both drugs in comparison with the strains of the group 2 patients. Also, C. albicans strains from this group of patients had a significantly lower (x) MIC in comparison to the mean values for the most of Candida species isolated from the hospitalized patients (P<0.001). In conclusion, we have found that the most Candida strains from both groups of patients were susceptible to the examined antifungal agents. The strains isolated from the outpatient clinic patients were generally more susceptible especially to itraconazole in comparison with strains from hospitalized patients.
    Źródło:
    Wiadomości Parazytologiczne; 2009, 55, 4; 415-423
    0043-5163
    Pojawia się w:
    Wiadomości Parazytologiczne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Leczenie grzybic powodowanych przez pleśnie i drożdżaki - przegląd piśmiennictwa
    Treatment of mycoses caused by moulds and yeasts - a literature review
    Autorzy:
    Gnat, Sebastian
    Łagowski, Dominik
    Powiązania:
    https://bibliotekanauki.pl/articles/22404501.pdf
    Data publikacji:
    2022
    Wydawca:
    Krajowa Izba Lekarsko-Weterynaryjna
    Tematy:
    mykologia weterynaryjna
    grzybice
    etiologia
    grzyby
    grzybice rozsiane
    eumycetoma
    keratomykoza
    kryptokokoza
    Malassezia pachydermatis
    leczenie
    leki przeciwgrzybicze
    drożdżaki
    pleśnie
    grzybice górnych dróg oddechowych
    grzybice worków powietrznych
    wrażliwość na leki
    fungi
    yeast
    mould
    treatment
    Opis:
    Veterinary medical mycology often differs from the human counterpart by the clinical aspects, the variety of fungi involved, and the antimycotic drugs available. Since the 1980s, there has been a significant increase in the number of humans affected by mycoses, and the spectrum of fungal species defined as pathogenic has broadened due to the increasing immunosuppression in the population. In veterinary mycology, this phenomenon has not been observed or is still insufficiently investigated. Only in the last few years the interest and awareness of the importance of animal mycoses and their treatment have increased. Convincing data present identification of previously human pathogens e.g. Cryptococcus gattii or Sporothrix brasiliensis, in animals. There are also revisions in taxonomy of some groups of fungi. The development of new antifungal drugs with better pharmacological properties, a broader spectrum of activity and fewer adverse effects was largely stimulated by the aforementioned increase of cases of fungal infections and the variety of causative agents. Some of these newly developed antifungal drugs are very expensive and, as is well known, economic considerations have a much greater influence on the decision to treat animals than it is in humans. Unfortunately, it is still often believed that the value of an animal is calculated in relation to the cost of therapy. This article reviews the literature on the treatment of fungal and yeast infections from the veterinary perspective of antifungal therapy. Particular attention was paid to the characteristics of disseminated mould mycoses in dogs, as there are numerous reports in the scientific literature in this field.
    Źródło:
    Życie Weterynaryjne; 2022, 97, 07; 453-459
    0137-6810
    Pojawia się w:
    Życie Weterynaryjne
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

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