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    Wyświetlanie 1-9 z 9
    Tytuł:
    Antivirals - current trends in fighting influenza
    Autorzy:
    Król, Ewelina
    Rychłowska, Małgorzata
    Szewczyk, Bogusław
    Powiązania:
    https://bibliotekanauki.pl/articles/1039254.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    influenza virus
    antivirals
    novel anti-influenza drugs
    antiviral therapy
    inhibitors
    Opis:
    Influenza virus infection is a major source of morbidity and mortality worldwide. Due to the variable effectiveness of existing vaccines, especially in the early stages of an epidemic, antiviral drugs represent the first line of defense against the virus. Currently, there are two major classes of anti-influenza drugs approved by the FDA for clinical use: M2 protein inhibitors (amantadine and rimantadine) and neuraminidase inhibitors (zanamivir and oseltamivir). However, increasing resistance to these available influenza antivirals among circulating influenza viruses highlights the need to develop alternative approaches for the prevention and/or treatment of influenza. This review presents an overview of currently available drugs for influenza treatment as well as summarizes some new antiviral strategies that are now being tested covering agents targeting both the viral proteins and the host-virus interaction. We discuss their mechanisms of action, resistance and the therapeutic potential as new antiviral drug for use in future influenza pandemics. Additionally, combination therapy based on these drugs is also described.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 495-504
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural biology of the influenza virus fusion peptide
    Autorzy:
    Worch, Remigiusz
    Powiązania:
    https://bibliotekanauki.pl/articles/1039239.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    influenza virus
    viral entry
    membrane fusion
    fusion peptide
    peptide-lipid interactions
    Opis:
    The release of influenza RNA inside the host cell occurs through the fusion of two membranes, the viral envelope and that of the cellular endosome. The fusion is mediated by the influenza hemagglutinin protein (HA), in particular by the fusion peptide (HAfp) located in the N-terminal fragment of HA2 subunit. This protein fragment anchors in the internal endosomal membrane, whereas the C-terminal HA2 part comprises a transmembrane domain (TMD) embedded in the viral envelope. A drop of pH in the endosome acts as the main trigger for HA2 large conformational change that leads to anchoring of the fusion peptide, close contact of the membranes and the subsequent fusion. Throughout the years the major research effort was focused on a 20-aminoacid fragment (HAfp1-20), shown by NMR to adopt a 'boomerang'-like structure. However, recent studies showed that extending HAfp1-20 by three highly conserved residues W21-Y22-G23 leads to formation of a unique, tight helical hairpin structure. This review summarizes recently discovered structural aspects of influenza fusion peptides and their relations with the membrane fusion mechanism.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 421-426
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Mapping of the influenza A hemagglutinin serotypes evolution by the ISSCOR method
    Autorzy:
    Radomski, Jan
    Słonimski, Piotr
    Zagórski-Ostoja, Włodzimierz
    Borowicz, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1039244.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    ISSCOR descriptors
    phylogenetic analysis
    influenza virus
    hemagglutinin
    phylogenetic maps
    Opis:
    Analyses and visualizations by the ISSCOR method of influenza virus hemagglutinin genes of different A-subtypes revealed some rather striking temporal relationships between groups of individual gene subsets. Based on these findings we consider application of the ISSCOR-PCA method for analyses of large sets of homologous genes to be a worthwhile addition to a toolbox of genomics - allowing for a rapid diagnostics of trends, and ultimately even aiding an early warning of newly emerging epidemiological threats.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 441-451
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antiviral activity of novel oseltamivir derivatives against some influenza virus strains
    Autorzy:
    Kocik, Janusz
    Kołodziej, Marcin
    Joniec, Justyna
    Kwiatek, Magdalena
    Bartoszcze, Michał
    Powiązania:
    https://bibliotekanauki.pl/articles/1039256.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    influenza virus
    neuraminidase inhibitors
    oseltamivir
    antiviral activity
    cytotoxicity
    Opis:
    The aim of this study was to investigate the in vitro cytotoxicity of oseltamivir derivatives and determine their activity against A/H1N1/PR/8/34 and A/H3N2/HongKong/8/68 - strains of influenza virus. Antiviral activity of these compounds was determined by using two methods. MTT staining was used to assess the viability of MDCK cells infected with influenza viruses and treated with various concentrations of drugs. In parallel, the effect of drugs on viral replication was assessed using the hemagglutination test. The most toxic compounds were: OS-64, OS-35, OS-29, OS-27 and OS-25, whereas OS-11, OS-20 and OS-23 were the least toxic ones. Statistically significant antiviral effect at a higher virus dose was shown by compounds: OS-11, OS-20, OS-27, OS-35, and OS-64. H3N2 virus was sensitive to 10-times lower concentrations of OS-11 and OS-35 than H1N1. At a lower infection dose, the antiviral activity was observed for OS-11, OS 27, OS-35 and OS-20. OS-64 turned out to be effective only at a high concentration. OS-23 showed no antiviral effect.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 509-513
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Detection and differentiation of Newcastle disease virus and influenza virus by using duplex real-time PCR
    Autorzy:
    Nidzworski, Dawid
    Wasilewska, Edyta
    Smietanka, Krzysztof
    Szewczyk, Bogusław
    Minta, Zenon
    Powiązania:
    https://bibliotekanauki.pl/articles/1039554.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Newcastle disease virus
    influenza virus
    detection
    differentiation
    real-time PCR
    duplex
    Opis:
    Newcastle disease virus (NDV), member of the Paramyxoviridae family and avian influenza virus (AIV), member of the Orthomyxoviridae family, are two main avian pathogens causing serious economic problems in poultry health. Both are enveloped, single-stranded, negative-sense RNA viruses and cause similar symptoms, ranging from sub-clinical infections to severe diseases, including decrease in egg production, acute respiratory syndrome, and high mortality. Similar symptoms hinder the differentiation of infection with the two viruses by standard veterinary procedures like clinical examination or necropsy. To overcome this problem, we have developed a new duplex real-time PCR assay for the detection and differentiation of these two viruses. Eighteen NDV strains, fourteen AIV strains, and twelve other (negative control) strains viruses were isolated from allantoic fluids of specific pathogen-free (SPF), embryonated eggs. Four-weeks-old SPF chickens were co-infected with both viruses (NDV - LaSota and AIV - H7N1). Swabs from cloaca and trachea were collected and examined. The results obtained in this study show that by using duplex real-time PCR, it was possible to detect and distinguish both viruses within less than three hours and with high sensitivity, even in case a bird was co-infected. Additionally, the results show the applicability of the real-time PCR assay in laboratory practice for the identification and differentiation of Newcastle disease and influenza A viruses in birds.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 3; 475-480
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    A universal flu vaccine
    Autorzy:
    Kesik-Brodacka, Malgorzata
    Plucienniczak, Grazyna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039259.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    universal vaccine
    flu vaccine
    influenza virus
    Opis:
    Influenza is a global health concern. The single most effective way of protecting people against influenza infection and disease is vaccination. However, currently available vaccines against influenza induce only strain-specific immunity, and do not elicit long-lasting serum antibody titers. Therefore, they are ineffective in the case of possible pandemics. There is an urgent need for a new generation vaccine which would induce broad and long-lasting immune protection against antigenically distinct flu viruses. The paper presents recent achievements and the challenges in the field of universal vaccine construction.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 3; 523-530
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Characterization of mAb6-9-1 monoclonal antibody against hemagglutinin of avian influenza virus H5N1 and its engineered derivative, single-chain variable fragment antibody
    Autorzy:
    Sawicka, Róża
    Siedlecki, Paweł
    Kalenik, Barbara
    Radomski, Jan
    Sączyńska, Violetta
    Porębska, Anna
    Szewczyk, Bogusław
    Sirko, Agnieszka
    Góra-Sochacka, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1038689.pdf
    Data publikacji:
    2017
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    influenza virus
    monoclonal antibody
    scFv
    hemagglutinin
    antigenic epitope
    Opis:
    Hemagglutinin (HA), as a major surface antigen of influenza virus, is widely used as a target for production of neutralizing antibodies. Monoclonal antibody, mAb6-9-1, directed against HA of highly pathogenic avian influenza virus A/swan/Poland/305-135V08/2006(H5N1) was purified from mouse hybridoma cells culture and characterized. The antigenic specificity of mAb6-9-1 was verified by testing its cross-reactivity with several variants of HA. The mimotopes recognized by mAb6-9-1 were selected from two types of phage display peptide libraries. The comparative structural model of the HA variant used for antibody generation was developed to further facilitate epitope mapping. Based on the sequences of the affinity- selected polypeptides and the structural model of HA the epitope was located to the region near the receptor binding site (RBS). Such localization of the epitope recognized by mAb6-9-1 is in concordance with its moderate hemagglutination inhibiting activity and its antigenic specificity. Additionally, total RNA isolated from the hybridoma cell line secreting mAb6-9-1 was used for obtaining two variants of cDNA encoding recombinant single-chain variable fragment (scFv) antibody. To ensure high production level and solubility in bacterial expression system, the scFv fragments were produced as chimeric proteins in fusion with thioredoxin or displayed on a phage surface after cloning into the phagemid vector. Specificity and affinity of the recombinant soluble and phage-bound scFv were assayed by suitable variants of ELISA test. The observed differences in specificity were discussed.
    Źródło:
    Acta Biochimica Polonica; 2017, 64, 1; 85-92
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    К вопросу экологии природноочаговых болезней (концептуально-аналитические исследования)
    To the issue of the ecology of environmental focal diseases (conceptual-analytical study)
    Autorzy:
    Golubyatnikov, M.
    Sidenko, V.
    Powiązania:
    https://bibliotekanauki.pl/articles/1032516.pdf
    Data publikacji:
    2014
    Wydawca:
    Uniwersytet Kazimierza Wielkiego w Bydgoszczy
    Tematy:
    природноочаговые болезни
    вирус гриппа
    эпидемический процесс
    environmental focal diseases
    influenza virus
    epidemic processes.
    Opis:
    К вопросу экологии природноочаговых болезней (концептуально-аналитические исследования) Проведены научно-аналитические исследования по проблеме экологии природноочаговых болезней. Основываясь на современных данных молекулярной биологии, вирусологии, иммунологии и эпидемиологии, авторы полагают, что происхождение биогенетических межвидовых экологических связей основывается на сапронозной природе, в частности, вирусов гриппа. На предадаптивной стадии миграционного процесса может стимулироваться возникновение некоторых вариантов, к которым восприимчивы околоводные птицы, а также отдельные млекопитающие, в том числе и человек. Разработка мер, препятствующих реассортации ныне является основой профилактики этой вирусной инфекции в будущем.
    To the issue of the ecology of environmental focal diseases (conceptual-analytical study) There was conducted the scientific-analytical study on the problem of the ecology of environmental focal diseases. Substantiated on the modern data of molecular biology, virology, immunology and epidemiology, the authors suggests that the origin of biogenetic interspecies associations are based on the sapronotic nature of influenza virus, particularly. On the preadaptive stage of migration process there are stimulated the occurrence of the variants whereas the water birds and mammalians, including humans, are susceptible. The development of the measures preventing reassociation is a base of the prevention of this viral infection in the future.
    Źródło:
    Journal of Health Sciences; 2014, 4, 1; 41-50
    1429-9623
    Pojawia się w:
    Journal of Health Sciences
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Zakażenia wirusowe układu oddechowego w środowisku pracy służby zdrowia
    Virus infections of the respiratory system in the occupational environment of health care employees
    Autorzy:
    Roży, A.
    Jaguś, P.
    Chorostowska-Wynimko, J.
    Powiązania:
    https://bibliotekanauki.pl/articles/179611.pdf
    Data publikacji:
    2014
    Wydawca:
    Centralny Instytut Ochrony Pracy
    Tematy:
    zakażenia wirusowe
    wirusy oddechowe
    wirus grypy
    personel medyczny
    viral infections
    respiratory viruses
    influenza virus
    health care workers
    Opis:
    Infekcje wirusowe dróg oddechowych stanowią poważny problem zdrowotny i ekonomiczny na całym Świecie wysoka zakaźność tej grupy wirusów bezpośrednio wynika z łatwości transmisji, szczególnie w większych skupiskach ludzkich, takich jak placówki medyczne i oświatowe, duże zakłady pracy czy środki transportu. Ryzyko zakażenia dla tych grup zawodowych, a zwłaszcza pracowników ochrony zdrowia fest więc znacząco wyższe. Konieczne jest świadome stosowanie zasad profilaktyki czynnej (szczepienia ochronne), a w okresie wzrostu zapadalności również profilaktyki biernej (izolacja zakażonych, higiena). Niski poziom wyszczepialności przeciw grypie w populacji polskiej, w tym również wśród pracowników opieki zdrowotnej stanowi istotny problem, niosący znaczące ryzyko dla zdrowotności społeczeństwa i gospodarki kraju.
    Respiratory viral infections pose a significant health and economic burden all over the world. Due to their easy transmission. respiratory viruses are highly infective, particularly in the larger human groupings, such as medical and educational facilities, larger industrial units and public transportation. Therefore, respective professional groups are regarded as the high risk population In those groups, in particular in medical staff, the premeditated proactive flu prophylaxis by means of regular immunization is strongly advised. A secondary prophylaxis, the strict isolation of infected patients must be introduced in health care facilities during flu season or epidemic. The unexceptionally low flu vaccination rate in Poland, both in general population and medical staff is of particular concern as a potential serious treat for society's state of health but also country economy.
    Źródło:
    Bezpieczeństwo Pracy : nauka i praktyka; 2014, 4; 27-29
    0137-7043
    Pojawia się w:
    Bezpieczeństwo Pracy : nauka i praktyka
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-9 z 9

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