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    Wyświetlanie 1-7 z 7
    Tytuł:
    Synthesis and potential cytotoxicity evaluation of carboxymethyl chitosan hydrogels
    Autorzy:
    Kłosiński, Karol K.
    Girek, Małgorzata K.
    Wach, Radosław A.
    Czechowska-Biskup, Renata
    Arkuszewski, Piotr T.
    Szymański, Paweł B
    Pasieka, Zbigniew
    Powiązania:
    https://bibliotekanauki.pl/articles/1034588.pdf
    Data publikacji:
    2017
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    PEGDA
    XTT
    carboxymethyl chitosan
    cytotoxicity
    hydrogel
    radiation crosslinking
    Opis:
    The aim of the research was to employ radiation to produce flexible carboxymethyl chitosan (CMCS) based hydrogels of uniform structure to characterise their swelling properties and cytocompatibility for potential applications as hydrogel wound dressings. CMCS in aqueous solution was irradiated with an electron beam in the presence of a poly(ethylene glycol) diacrylate (PEGDA) macromonomer as a crosslinker, at 12 different compositions, i.e. 3–20% CMCS, 3 and 5% PEGDA. The obtained hydrogels were subjected to sol–gel analysis. The amount of insoluble fraction (up to 100%) rose with an increase in the PEGDA/polysaccharide ratio. Moreover, the equilibrium degree of swelling, ca. 15 to 200 g of water per g of gel, which was higher for lower content of crosslinker, decreased with the delivered dose, which was associated with an increase in crosslinking density. The in vitro XTT cell viability assay (murine fibroblasts, L929 cell line) showed no significant cytotoxicity of CMCS gels.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2017, 22; 82-96
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Synthesis of chitosan and carboxymethyl chitosan hydrogels by electron beam irradiation
    Autorzy:
    Czechowska-Biskup, Renata
    Wach, Radosław
    Stojek, Piotr
    Kamińska, Martyna
    Rosiak, Janusz M.
    Ulański, Piotr
    Powiązania:
    https://bibliotekanauki.pl/articles/1034681.pdf
    Data publikacji:
    2016
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    PEGDA
    carboxymethyl chitosan
    chitosan
    hydrogel
    radiation crosslinking
    Opis:
    Solutions of chitosan (CS) and carboxymethyl chitosan (CMCS) were subjected to irradiation by electron beam in presence of a crosslinking agent (poly(ethylene glycol) diacrylate - PEGDA) in order to produce carboxymethyl chitosan- and chitosan-based hydrogels. PEGDA macromonomer itself undergoes simultaneous polymerization and crosslinking either in neutral water or in acidic medium. Acidic solutions of chitosan of 0.5, 1 and 2% can be effectively crosslinked with PEGDA to form a gel. Although CMCS undergoes radiation-initiated crosslinking only at high concentration in water (over 10%), the presence of PEGDA in solution facilitated hydrogel formation even at lower concentration of CMCS. Formation of CS and CMCS hydrogels required irradiation doses lower than those needed for sterilization, i.e. 25 kGy, in some cases even as low as 200 Gy. Sol-gel analysis revealed relatively high gel fraction of obtained hydrogels, up to 80%, and good swelling ability. Both parameters can be easily controlled by composition of the initial solution and irradiation dose. Possible mechanisms of crosslinking reactions were proposed, involving addition of the polysaccharide macroradicals to a terminal double bond of PEGDA.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2016, 21; 27-45
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Preparation and characterization of a new generation of chitosan hydrogels containing pyrimidine ribonucleotides
    Autorzy:
    Pieklarz, Katarzyna
    Tylman, Michał
    Modrzejewska, Zofia
    Powiązania:
    https://bibliotekanauki.pl/articles/1034023.pdf
    Data publikacji:
    2020
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    biomaterial
    chitosan
    hydrogel
    neural tissue regeneration
    Opis:
    Damage to the nervous system, in particular spinal cord injuries, is a burden for the patient and is usually the cause of irreversible disability. The progress observed in the last decade in the fields of biology, biomaterial engineering and neurosurgery has created new treatment solutions while preventing further neurodegenerative processes. The most important research is focused on the implementation of polymer structures in clinical practice, especially chitosan hydrogels, which are the scaffolds for regenerating axons. This article presents a new generation of biomaterials that have the ability to gel in response to temperature changes; they are intended for injectable scaffolds for nerve cell cultures. Two types of hydrogels were prepared based on chitosan lactate and chitosan chloride using uridine 5’-monophosphate disodium salt. The structure of the systems was observed under a scanning electron microscope and examined using Fourier transform infrared spectroscopy. In addition, thermal properties were tested using differential scanning calorimetry.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 192-200
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Structural characteristics of thermosensitive chitosan glutaminate hydrogels
    Autorzy:
    Modrzejewska, Zofia
    Nawrotek, Katarzyna
    Zarzycki, R
    Douglas, Timothz
    Powiązania:
    https://bibliotekanauki.pl/articles/1035319.pdf
    Data publikacji:
    2013
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    chitosan
    hydrogel
    natural polymer
    structural properties
    Opis:
    Hydrogels that possess the ability of gelling in response to changes in the local environment, such as pH or temperature, have been examined extensively recently. In this paper the properties of thermosensitive chitosan hydrogels prepared with the use of chitosan glutaminate and -glycerophosphate are presented. The sol/gel transition point was determined based on the rheological properties. The structure of gels was observed under the Scanning Electron Microscopy (SEM) and was investigated by thermogravimetric (TG) and differential themogravimetric (DTG) analy¬sis and infrared (IR) spectroscopy. The crystallinity of gel structure was determined by X-ray Diffraction analysis (XRD).
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 93-105
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Wpływ substancji czynnych na własności reologiczne hydrożeli chitozanowych w pobliżu granicy przejścia fazowego zol-żel
    Influence of active substances on rheological properties of chitosan hydrogels near sol-gel phase transition
    Autorzy:
    Owczarz, P.
    Modrzejewska, Z.
    Powiązania:
    https://bibliotekanauki.pl/articles/2071912.pdf
    Data publikacji:
    2012
    Wydawca:
    Stowarzyszenie Inżynierów i Techników Mechaników Polskich
    Tematy:
    chitozan
    hydrożele
    reologia hydrożeli
    matryce polimerowe
    chitosan
    hydrogel
    rheology of hydrogels
    polymeric network
    Opis:
    W pracy przedstawiono wyniki badań Teologicznych hydrożeli chitozanowych tworzących matrycę polimerową dla substancji czynnych. Jako substancje czynne stosowano albuminę wołową oraz wankomycynę. Inhibitorem przejścia fazowego zol-żel była zmiana temperatury roztworu. Wyznaczone własności reologiczne oraz krzywe temperaturowe roztworów wykazały, że w przypadku albuminy otrzymany roztwór zachowuje podobne własności jak wyjściowy roztwór chitozanu. W przypadku wankomycyny zainicjowany zmianą temperatury proces żelowania prowadzi do wytworzenia nieodwracalnej struktury.
    Rheological properties of chitosan hydrogels forming polymeric network for active substances are presented in the paper. Bovine serum albumin and vancomycin were used as active substances. A change in solution tem-perature acted as an inhibitor of sol-gel phase transition. The determined rheological properties and temperature curves of solutions showed properties similar to those of initial chitosan solution. In case of vancomycin the gelation process initiated by a temperature change led to the formation of irreversible structure.
    Źródło:
    Inżynieria i Aparatura Chemiczna; 2012, 6; 364-365
    0368-0827
    Pojawia się w:
    Inżynieria i Aparatura Chemiczna
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Double crosslinking of chitosan/vanillin hydrogels as a basis for mechanically strong gradient scaffolds for tissue engineering
    Autorzy:
    Hunger, Martyna
    Domalik-Pyzik, Patrycja
    Reczyńska, Katarzyna
    Chłopek, Jan
    Powiązania:
    https://bibliotekanauki.pl/articles/1844976.pdf
    Data publikacji:
    2020
    Wydawca:
    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
    Tematy:
    hydrogel
    chitosan
    vanillin
    tripolyphosphate
    tissue engineering
    Opis:
    Polysaccharides, such as chitosan (CS), are widely used in many biomedical applications. However, they require crosslinking agents to achieve chemical stability and appropriate mechanical properties. In this work, chitosan-based hydrogels were crosslinked using vanillin and/or sodium tripolyphosphate, as chemical and physical crosslinking agents, respectively. Microstructural (digital microscope, SEM), structural (FTIR-ATR), mechanical (static compression test), and in vitro biological (chemical stability and swelling ratio in PBS, cytotoxicity) properties of the obtained materials were evaluated to assess materials potential as biomedical scaffolds. The optimal ratio of vanillin to chitosan (DD = 89%) to crosslink the polymer was found to be 1.2:1. Moreover, the double crosslinking with vanillin caused a two-time increase in the compression strength of the samples and led to the slower biodegradability. Cytotoxicity studies showed that the cells prefer double vanillin crosslinked hydrogels over those treated with TPP. Further studies, such as bioactivity are required to determine the specific functionality of the hydrogels and the specific tissue which may be treated with the tested materials. The optimal material was chosen to the next step of the study, which may be obtaining composite hydrogels with hydroxyapatite and/or graphene oxide to tailor or improve properties towards specific tissue regeneration.
    Źródło:
    Engineering of Biomaterials; 2020, 23, 155; 2-11
    1429-7248
    Pojawia się w:
    Engineering of Biomaterials
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Cytotoxicity of chitosan based thermo-sensitive hydrogels intended for nervous tissue engineering
    Autorzy:
    Nawrotek, Katarzyna
    Modrzejewska, Zofia
    Paluch, Danuta
    Zarzycki, Roman
    Rusak, Agnieszka
    Powiązania:
    https://bibliotekanauki.pl/articles/1034899.pdf
    Data publikacji:
    2015
    Wydawca:
    Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
    Tematy:
    Chitosan
    biomaterial
    hydrogel
    nervous tissue regeneration
    Opis:
    The damage to the central nervous system is one of the most difficult cases of trauma to treat. Over the last few years, increasing attention has been focused on the development of strategies based on biomaterials for regeneration and repair of the spinal cord injury. In particular, materials in the form of hydrogels based on chitosan are being actively investigated due to their intrinsic properties that are favorable in spinal cord tissue regeneration. The purpose of this study was to develop a thermo-gelling chitosan solution that will be prepared with the use of acids that naturally occur in the human nervous tissue. For this purpose, two types of chitosan gels were prepared based on chitosan glutamate and chitosan lactate. In order to reduce toxic action of the system obtained gels were conditioned in distilled water with pH 5.00. The changes in the structures of systems obtained were determined with the use of FTIR method. Biocompatibility was primarily evaluated through cytotoxicity testing by MTT assay with respect to mouse fibroblast cells.
    Źródło:
    Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 222-235
    1896-5644
    Pojawia się w:
    Progress on Chemistry and Application of Chitin and its Derivatives
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-7 z 7

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