- Tytuł:
- Toxicity of Some Phenolic Derivatives : In Vitro Studies
- Autorzy:
- Zapór, L.
- Powiązania:
- https://bibliotekanauki.pl/articles/89791.pdf
- Data publikacji:
- 2004
- Wydawca:
- Centralny Instytut Ochrony Pracy
- Tematy:
-
phenol
catechol
resorcinol
hydroquinone
phloroglucinol
cytotoxicity
fenol
hydrochinon
badania in vitro
działanie toksyczne
substancje toksyczne
rezorcynol
zagrożenia chemiczne - Opis:
- Cytotoxicity of 5 phenol derivatives (phenol, catechol, resorcinol, hydroquinone and phloroglucinol) wastested using a mouse 3T3 fibroblast cell line. Its relationships with structural and physicochemical properties were investigated. Linear regression analysis and Pearson’s correlation coefficient were used to characterise the relationship between cytotoxicity (expressed by IC50 values) and physicochemical parameters of compounds or their toxicity in vivo expressed by LD50 values. The studies showed that physicochemical properties of compounds seemed to have less influence on their cytotoxic potency than structural properties. Cytotoxicity of the compounds probably depends on the number of -OH groups and their location in the aromatic ring more than on physicochemical properties of compounds. The best correlation was obtained for IC50 values and LD50 values determined following rabbit skin administration and experimental skin irritation score.
- Źródło:
-
International Journal of Occupational Safety and Ergonomics; 2004, 10, 4; 319-331
1080-3548 - Pojawia się w:
- International Journal of Occupational Safety and Ergonomics
- Dostawca treści:
- Biblioteka Nauki
Artykuł