- Tytuł:
-
Inhibitory cholinoesteraz w terapii choroby Alzheimera
Cholinesterase inhibitors in Alzheimer disease therapy - Autorzy:
-
Zawadzka, A.
Czarnocki, Z. - Powiązania:
- https://bibliotekanauki.pl/articles/172066.pdf
- Data publikacji:
- 2015
- Wydawca:
- Polskie Towarzystwo Chemiczne
- Tematy:
-
choroba Alzheimera
inhibitory cholinoesteraz
leki hybrydowe
związki o wielokierunkowym działaniu
Alzheimer's disease
cholinesterase inhibitors
hybrid drugs
multi target directed ligands
MTDLs - Opis:
- In recent years, a progressive increase in age-related disorders could be observed in most western countries, among which Alzheimer’s disease (AD) is one of the most challenging. The progress of AD is characterized by a severe loss in memory and cognition, leading to behavioral changing, depression and death. Currently approved treatments, including the acetylcholinesterase inhibitors (AChEIs) donepezil, galantamine and rivastigmine and N-methyl-d-aspartate (NMDA) antagonist memantine, do not halt the progression of the disease. The discovering of multifunctional compounds considering that several dual binding site AChEIs were able to reach different targets, guided the development of new drug design strategy, the multi-target-directed ligand (MTDL) approach. This review shows briefly summaries past and present research on the cholinesterase inhibitors (ChIs) able to interact with other targets contributing in aetiology of Alzheimer’s disease.
- Źródło:
-
Wiadomości Chemiczne; 2015, 69, 9-10; 767-788
0043-5104
2300-0295 - Pojawia się w:
- Wiadomości Chemiczne
- Dostawca treści:
- Biblioteka Nauki
Artykuł