- Tytuł:
- Effects of granulocyte colony-stimulating factor therapy for osteogenesis imperfecta: a case report
- Autorzy:
-
Paszko-Patej, G.
Sienkiewicz, D.
Kułak, W.
Okurowska-Zawada, B.
Wojtkowski, J.
Kalinowska, A.
Okulczyk, K.
Sochoń, K.
Dmitruk, E.
Mirska, A. - Powiązania:
- https://bibliotekanauki.pl/articles/1918408.pdf
- Data publikacji:
- 2017
- Wydawca:
- Uniwersytet Medyczny w Białymstoku
- Tematy:
-
Osteogenesis imperfecta
granulocyte colony-stimulating factor
muscle strength - Opis:
- Introduction: Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and low bone mass. OI type IV. Materials and methods: We examined the safety and effectiveness of a low dose of analog granulocyte colony-stimulating factor (G-CSF) in a 15-year-old girl OI type IV. G-CSF 5 μg/kg was given subcutaneously, for 5 days/month for 3, 6 and 12 months. Laboratory tests, including blood, biochemical tests were performed, in addition to clinical examination.Results: Clinical examination revealed an increase of muscle strength in the upper and lower limbs between base line and day 6 and 12 months. We found no serious adverse events. Leukocyte levels remained below 38,000/μL. Low dose G-CSF was safe and well tolerated by the patient. Conclusions: A significant increase in muscle strength in this patient may indicate beneficial effects of G-CSF factor in this disorder. These results are inspiring and warrant further studies.
- Źródło:
-
Progress in Health Sciences; 2017, 7(1); 205-208
2083-1617 - Pojawia się w:
- Progress in Health Sciences
- Dostawca treści:
- Biblioteka Nauki
Artykuł