- Tytuł:
- The interaction of new oxicam derivatives with lipid bilayers as measured by calorimetry and fluorescence spectroscopy
- Autorzy:
-
Maniewska, Jadwiga
Gąsiorowska, Justyna
Szczęśniak-Sięga, Berenika
Michalak, Krystyna - Powiązania:
- https://bibliotekanauki.pl/articles/1038386.pdf
- Data publikacji:
- 2018
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
oxicam derivatives
NSAIDs analogues
piroxicam
1,2- benzothiazine derivatives synthesis
model lipid bilayers
differential scanning calorimetry (DSC)
fluorescence spectroscopy - Opis:
- The purpose of the present work was to assess the ability of five new oxicam analogues to interact with the lipid bilayers. To characterize the interaction of newly synthesized NSAIDs (non-steroidal anti-inflammatory drugs) analogues with DPPC lipid bilayers the two following techniques were applied - differential scanning calorimetry (DSC) and fluorescence spectroscopy. The results obtained by these experimental approaches show that new oxicams analogues interact with the lipid model membranes under consideration. As demonstrated both in calorimetric and spectroscopic studies, the greatest influence on the thermotropic properties of the lipid membrane and on the quenching of fluorescence of Laurdan and Prodan was exerted by a derivative named PR47 containing in its structure a two-carbon aliphatic linker with a carbonyl group, as well as bromine and trifluoromethyl substituents.
- Źródło:
-
Acta Biochimica Polonica; 2018, 65, 2; 185-191
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł