- Tytuł:
- Isolation, characterization and evaluation of anti-proliferative properties of andrographolide isolated from Andrographis paniculata on cultured HaCaT cells
- Autorzy:
-
Jindal, S.
Awasthi, R.
Singare, D.
Kulkarni, G.T. - Powiązania:
- https://bibliotekanauki.pl/articles/2049322.pdf
- Data publikacji:
- 2021
- Wydawca:
- Instytut Włókien Naturalnych i Roślin Zielarskich
- Tematy:
-
Andrographis paniculata
andrographolide
psoriasis
inflammatory skin disease
proliferation
keratinocyte
epidermis
andrografolid
brodziuszka wiechowata
łuszczyca
keratynocyty naskórka
działanie antyproliferacyjne - Opis:
- Introduction: Psoriasis is an inflammatory skin disease characterized by hyper-proliferation, abnormal epidermal keratinocytes and inflammatory infiltration. It affects approximately 4% of the population globally. Herbal extracts have better results with less toxic effects than the synthetic drugs in the treatment of psoriasis. Objective: Present study was aimed to access the anti-psoriatic effect of andrographolide extracted from Andrographis paniculate (A. paniculata). Method: We extracted, characterized, and screened the extracted andrographolide for anti-proliferative characteristics using cultured cell model of human HaCaT keratinocyte. Results: Andrographolide at 31.25 µg/mL (90 µM) demonstrated significant inhibitory effect on human HaCaT keratinocytes proliferation in cell culture. To our best knowledge, we reported the anti-proliferative potency of andrographolide extracted from A. paniculata for the first time. Conclusion: The results suggest that the andrographolide extracted from A. paniculata plant may have potential to be used in the management of psoriasis.
- Źródło:
-
Herba Polonica; 2021, 67, 1; 35-45
0018-0599 - Pojawia się w:
- Herba Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł