Autor: Luszczki, J.J. - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Interaction of tiagabine with clonazepam in the mouse pentylenetetrazole-induced seizure model: a type I isobolographic analysis for parallel log-probit dose-response relationship lines
Autorzy:: Luszczki, J.J.
Krzyzanowski, M.
Sielski, M.
Wojda, E.
Swiader, M.J.
Powiązania:: https://bibliotekanauki.pl/articles/3327.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: drug interaction
tiagabine
clonazepam
mouse
mice
pentylenetetrazole-induced seizure
isobolographic analysis
dose-response relationship
laboratory animal
experimental condition
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Interactions of levetiracetam with ethosuximide in the mouse 6 Hz psychomotor seizure model - a type II isobolographic analysis
Autorzy:: Luszczki, J.J.
Wlaz, A.
Kondrat-Wrobel, M.W.
Pyrka, D.
Florek-Luszczki, M.
Powiązania:: https://bibliotekanauki.pl/articles/3145.pdf
Data publikacji:: 2014
Wydawca:: Instytut Medycyny Wsi
Tematy:: 6 Hz psychomotor seizure model
antiepileptic drug
drug interaction
ethosuximide
levetiracetam
isobolographic analysis
Opis:: The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in combination with ethosuximide in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes; type II isobolographic analysis was used to characterize the consequent anticonvulsant interactions between the drug combinations for fixed-ratios of 1:1, 1:2, 1:5 and 1:10. With type II isobolographic analysis, the combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 were supra-additive (synergistic; P<0.05 and P<0.01, respectively) in terms of seizure suppression, while the combinations for the fixed-ratios of 1:1 and 1:2 were additive in the mouse 6 Hz psychomotor seizure model. The combinations of levetiracetam with ethosuximide for the fixed-ratios of 1:5 and 1:10 appear to be particularly favorable combinations exerting supra-additive interaction in the mouse 6 Hz psychomotor seizure model. Finally, it may be concluded that because of the synergistic interactions between levetiracetam and ethosuximide, the combination might be useful in clinical practice.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2014, 08, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Diltiazem enhances the protective activity of oxcarbazepine against maximal electroshock-induced seizures in mice
Autorzy:: Zadrozniak, A.
Trojnar, M.K.
Trojnar, M.P.
Kimber-Trojnar, Z.
Dudra-Jastrzebska, M.
Andres-Mach, M.M.
Luszczki, J.J.
Powiązania:: https://bibliotekanauki.pl/articles/3526.pdf
Data publikacji:: 2008
Wydawca:: Instytut Medycyny Wsi
Tematy:: calcium channel antagonist
diltiazem
protective activity
oxcarbazepine
maximal electroshock-induced seizure
mice
mouse
drug interaction
pharmacodynamic interaction
Źródło:: Journal of Pre-Clinical and Clinical Research; 2008, 02, 2
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Interactions of retigabine with topiramate in the mouse tonic-clonic seizure model and chimney test - an isobolographic analysis
Autorzy:: Zagaja, Mirosław
Miziak, Barbara
Kondrat-Wróbel, Maria W.
Andres-Mach, Marta
Wróblewska-Łuczka, Paula
Adamczuk, Piotr
Chmura, Robert
Czuczwar, Stanisław Jerzy
Łuszczki, Jarogniew J.
Powiązania:: https://bibliotekanauki.pl/articles/972722.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: maximal electro-shock
drug interaction
isobolographic analysis
Retigabine
Topiramate
Opis:: Introduction and objectives. Nowadays, one of the treatment options for patients with refractory epilepsy is polytherapy with two or more antiepileptic drugs (AEDs). Retigabine (RTG) is a novel third-generation AED with unique molecular mechanisms of action that has recently been approved as an add-on drug for the treatment of tonic-clonic seizures. To characterize types of interactions between RTG and topiramate (TPM – a second-generation AED), the maximal electroshock- induced seizure model (MES) and chimney test in mice were used. Materials and method. In the MES model, the anticonvulsant effects of the drugs in terms of suppression of tonic-clonic seizures in male albino Swiss mice were assessed. In the chimney test, the acute neurotoxic effects of the drugs with respect to impairment of motor coordination were determined. Type I isobolographic analysis for the combination of RTG and TPM was applied to assess the anticonvulsant and neurotoxic effects in both the MES and chimney tests. Total brain concentrations of RTG and TPM were measured to exclude any pharmacokinetic interaction between drugs. Results. The type I isobolographic analysis of interaction revealed that the combination of RTG with TPM produced additive interaction in the MES test and additivity, with a slight tendency towards antagonism in terms of acute neurotoxic effects in the chimney test. Neither RTG nor TPM mutually affected total brain concentrations in the experimental animals. Conclusions. The isobolographically analyzed combination of RTG with TPM is favourable and may be recommended to some patients with refractory epilepsy.
Źródło:: Journal of Pre-Clinical and Clinical Research; 2017, 11, 1; 61-65
1898-2395
Pojawia się w:: Journal of Pre-Clinical and Clinical Research
Dostawca treści:: Biblioteka Nauki

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