- Tytuł:
- Cd2+-promoted mitochondrial permeability transition: a comparison with other heavy metals.
- Autorzy:
-
Belyaeva, Elena
Glazunov, Vadim
Korotkov, Sergey - Powiązania:
- https://bibliotekanauki.pl/articles/1043302.pdf
- Data publikacji:
- 2004
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
copper
mercury
mitochondrial permeability transition
respiratory chain
cadmium - Opis:
- We compared action of Cd2+, Hg2+, and Cu2+ on isolated rat liver mitochondria in the absence of added Ca2+ and Pi. The heavy-metal ions produced dose-dependently: (1) enhanced membrane permeabilizaton manifested in mitochondrial swelling and activation of basal respiration, (2) inhibition of uncoupler-stimulated respiration, and (3) membrane potential dissipation. Among the metals, Cu2+ exhibited maximal stimulatory effect on basal respiration and minimal inhibitory action on DNP-uncoupled respiration whilst Cd2+ promoted the strongest depression of uncoupled respiration and the largest swelling in NH4NO3 medium. Dithiothreitol induced a basal respiration release if added after high [Cd2+] and [Hg2+], and the stimulation was CsA-insensitive.
- Źródło:
-
Acta Biochimica Polonica; 2004, 51, 2; 545-551
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł