Temat: cancer, - Katalog OPAC zbiorów

Skocz do pozycji: 1.

Tytuł:: Knowledge and Awareness of Colorectal Cancer
Autorzy:: Lewandowski, Miłosz
Lipiński, Przemysław
Bednarski, Igor
Mik, Michał
Dziki, Adam
Powiązania:: https://bibliotekanauki.pl/articles/1391790.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: awareness
colon cancer
colonoscopy
colorectal cancer
rectal cancer
stomy
Opis:: Introduction: Colorectal cancer (CRC) is the third most common malignancy in men and the second most common in women. The disease constitutes a significant civilization and social problem. The aim: The aim of the study is to assess the sudy group’s awareness and knowledge about CRC, as well as about its diagnostics and treatment. Material and methods: An online questionaire form was distributed in the study group regarding issues related to CRC, and followed by statistical analysis and interpretation of the obtained survey results. Results: After analysis, we found that a significant percentage of the surveyed sample group had basic knowledge and awareness in the area of CRC, whereas about half of the respondents did not consider themselves sufficiently informed about the disease. Conclusions: Considering the scale of the problem posed by CRC, it is necessary to undertake broader action to promote knowledge about this disease and to carry out this type of research on a larger and more socioeconomically diverse population.
Źródło:: Polish Journal of Surgery; 2020, 92, 2; 34-41
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 2.

Tytuł:: Young Patient Age as the Cause of Delayed Diagnosis of Gastrointestinal Carcinoma
Autorzy:: Zaręba, Konrad
Bandurski, Roman
Kędra, Bogusław
Powiązania:: https://bibliotekanauki.pl/articles/1396688.pdf
Data publikacji:: 2012-06-01
Wydawca:: Index Copernicus International
Tematy:: pancreatic cancer
gastric cancer
colorectal cancer
young patient age
Opis:: Most patients diagnosed with gastrointestinal carcinomas are older people. The above-mentioned fact may lead to an erroneous finding that the problem does not concern patients aged between 20 and 30 years. Unfortunately, this assumption is often the reason for late diagnosis and delayed treatment of these malignancies. The study presented an example of three patients subject to surgical management of gastrointestinal carcinomas at the II Department of General and Gastroenterological Surgery, Medical University in Białystok.
Źródło:: Polish Journal of Surgery; 2012, 84, 6; 317-321
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 3.

Tytuł:: Assessment of changes in body composition measured with bioelectrical impedance in patients operated for pancreatic, gastric and colorectal cancer
Autorzy:: Dzierżek, Przemysław
Kurnol, Krzysztof
Hap, Wojciech
Frejlich, Ewelina
Diakun, Agata
Karwowski, Adrian
Kotulski, Krzysztof
Rudno-Rudzińska, Julia
Kielan, Wojciech
Powiązania:: https://bibliotekanauki.pl/articles/1391802.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: body composition
cioelectrical impedance
colorectal cancer
pancreatic cancer
stomach cancer
Opis:: ntroduction: A proper level of nutrition is significant in the period of convalescence in patients subject to major surgical procedures, particularly due to neoplastic disease. Bioelectrical Impedance Analysis, or BIA is a widely used method in assessing body mass composition. BIA measurement is easy, quick, cheap and repetitive. Material and methods: We assessed the body composition of 56 patients (25 women and 31 men) hospitalized and operated at the Department of General and Oncological Surgery of the Wroclaw Medical University in the years 2017–2018 using bioelectric impedance. Results: The average body weight loss in the 4th postoperative day was 1.32% of body mass and on the day of release from hospital – 4.23% of body mass in relation to body mass upon admission. The percentage of body fat (FM – Fat Mass) in patients admitted to the department is above the normal range. The change in body composition in hospitalized patients mainly concerns the amount of adipose tissue and the amount of extracellular and intracellular water (ECW – Extracellular Water; ICW – Intracellular Water). Conclusions: Bioelectrical impedance can be an easy and effective method of assessing body composition and its change in patients undergoing major surgery. Amongst the analyzed groups, patients operated for pancreatic cancer lose the largest percentage of body weight until discharge from the department. Loss of body mass mainly occurs as loss of fat mass (FM).
Źródło:: Polish Journal of Surgery; 2020, 92, 2; 8-11
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 4.

Tytuł:: Symptoms of colorectal cancer contributes to its localization and advancement
Autorzy:: Nizioł, M.
Kostrzewska, B.
Kamińska, D.
Domurat, M.
Zińczuk, J.
Misiura, M.
Guzińska-Ustymowicz, K.
Pryczynicz, A.
Powiązania:: https://bibliotekanauki.pl/articles/1918846.pdf
Data publikacji:: 2019-08-26
Wydawca:: Uniwersytet Medyczny w Białymstoku
Tematy:: Cancer localization
colorectal cancer
symptoms
Opis:: Introduction: Colorectal cancer is one of the most common cancers occurring in Poland. Unfortunately, this cancer is most often diagnosed at the time of great advancement. This is caused by the appearance of specific symptoms only in the late stages of cancer. Also, such low detection of early stages of adenocarcinoma may be caused by disregarding of slight symptoms. Purpose: To analyse symptoms in patients with colorectal cancer and correlate with chosen clinical-pathological parameters. Materials and methods: The study group consisted of 46 patients diagnosed with colorectal cancer. Information on symptoms associated with cancer (subjective and objective) have been selected from patients' medical history. The presence of these symptoms was correlated with the age and sex of patients, tumor location, histological type of cancer, grade of histological malignancy (G), stage of tumor (T stage), presence of lymph node metastases and distant metastases. Results: It has been shown that the presence of pain complaints described by the patient are associated with the occurrence of cancer in the colon. The painfulness and pathological resistance diagnosed by the physician are more often associated with cancer located in the colon. In the case of tumors located in the rectum, faecal admixtures appear more frequently. It has also been shown that the presence of admixtures of blood and mucus in the stool is associated with more advanced local tumors, infiltrating pericolorectal tissues (T3 + T4). Conclusions: Familiarity with clinical symptoms of colorectal cancer could make patients more sensitive to more often screening for cancer. Analysis of these symptoms could indicate to the physician the location or stage of the cancer.
Źródło:: Progress in Health Sciences; 2019, 1; 76-82
2083-1617
Pojawia się w:: Progress in Health Sciences
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 5.

Tytuł:: Synchronous Gastric and Rectal Cancer in a 50 Year-Old Man – Case Report
Autorzy:: Pierko, Jacek
Łukaszewicz, Jerzy
Sawicka-Pierko, Anna
Hady, Hady Razak
Dadan, Jacek
Powiązania:: https://bibliotekanauki.pl/articles/1396903.pdf
Data publikacji:: 2012-12-01
Wydawca:: Index Copernicus International
Tematy:: synchronous tumor
gastric cancer
colorectal cancer
Opis:: The occurrence of synchronous tumors of the gastrointestinal tract is rarely observed in general surgery, diagnosis is frequently incidental, often intraoperatively. The aim of this study was to present a case of a 50 year-old male patient admitted to the Department of Gastroenterology, University Hospital in Białystok, due to abdominal pain, significant weakness and excretion of tarry stools. Imaging diagnostics revealed the presence of a large gastric tumor (histopathological type - adenocarcinoma), and single metastasis to the liver. The patient was qualified for total gastrectomy. Surgery was performed at the 1st Department of General and Endocrinological Surgery, University Hospital in Białystok. Rectal cancer, which was observed during the operation was removed simultaneously.
Źródło:: Polish Journal of Surgery; 2012, 84, 11; 582-584
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 6.

Tytuł:: Prognostic significance of p53 protein accumulation in cancer cells obtained from selected group of patients with sporadic colorectal cancer
Autorzy:: Paluszkiewicz, P
Karski, J.
Berbec, H.
Pawlowska-Wakowicz, B.
Cybulski, M.
Karski, M.
Paszkowska, A.
Powiązania:: https://bibliotekanauki.pl/articles/2043897.pdf
Data publikacji:: 1999
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: patient
cancer cell
monoclonal antibody
p53 protein
cancer prognosis
immunohistochemistry
sporadic colorectal cancer
accumulation
colorectal cancer
Źródło:: Journal of Applied Genetics; 1999, 40, 2; 135-144
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 7.

Tytuł:: Age at diagnosis of cancer as predictor of mutation accurrence in families suspected of HNPCC
Autorzy:: Kurzawski, G
Debniak, T.
Kladny, J.
Lubinski, J.
Powiązania:: https://bibliotekanauki.pl/articles/2041741.pdf
Data publikacji:: 2001
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: diagnosis
mutation
age
colorectal cancer
mutational analysis
cancer
Źródło:: Journal of Applied Genetics; 2001, 42, 3; 359-366
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 8.

Tytuł:: Sirt3 regulates the level of mitochondrial DNA repair activity through deacetylation of NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 in colorectal cancer
Autorzy:: Kabziński, Jacek
Walczak, Anna
Mik, Michał
Majsterek, Ireneusz
Powiązania:: https://bibliotekanauki.pl/articles/1391859.pdf
Data publikacji:: 2020
Wydawca:: Index Copernicus International
Tematy:: cancer
colorectal cancer
DNA damage/repair
genetics
proteins
Opis:: Colorectal cancer (CRC) is one of the most common malignant tumors. One of the factors increasing the risk of its occurrence may be the reduced efficiency of repairing DNA damage, both nuclear and mitochondrial. The main mechanism for repairing oxidative damage is the BER system (in mitochondria mtBER), whose key proteins NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 obtain full efficiency only at the appropriate level of acetylation. Sirtuin 3 is a key protein for mitochondrial homeostasis, regulating a number of metabolic processes related mainly to the control of the level of reactive oxygen species. Because Sirt3 possesses acetylase activity, it can modulate the level of activity of mtBER proteins by their deacetylation. The conducted study showed that the tested proteins NEIL1, NEIL2, OGG1, MUTYH, APE1 and LIG3 are the substrate for the enzymatic deacetylation activity of Sirt3, which may lead to modulation of the risk of CRC, and in cancer cells may be a potential therapeutic target enhancing the action of cytostatic drugs.
Źródło:: Polish Journal of Surgery; 2020, 92, 1; 1-4
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 9.

Tytuł:: Profilaktyka w systemie ochrony zdrowia – walka z nowotworami i chorobami układu krążenia
Prevention in the Health Protection System – Fight against Cancer and Cardiovascular Diseases
Autorzy:: Paszkiewicz, Dorota
Piotrkowski, Jan
Powiązania:: https://bibliotekanauki.pl/articles/417004.pdf
Data publikacji:: 2017-08
Wydawca:: Najwyższa Izba Kontroli
Tematy:: prophylaxis
health care system
breast cancer
cervical cancer
colorectal cancer
diseases of modern civilisation
Opis:: Observing its importance to human health, NIK, on its own initiative, conducted an audit whose main objective was to evaluate health prevention in the areas of gastroenterology, gynaecology and cardiology, related to prevention of cancer and cardiovascular diseases, as well as the effects of these diseases. The audit covered secondary prevention that consists in early detection of pathological processes/changes. In their article, the authors present the detailed findings of the audit.
Źródło:: Kontrola Państwowa; 2017, 62, 4 (375); 77-96
0452-5027
Pojawia się w:: Kontrola Państwowa
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 10.

Tytuł:: Assessment Of the surgical treatment results IN patients with colorectal cancer IN A district hospital versus treatment results IN A highly specialized center
Autorzy:: Ciesielski, Przemysław
Berut, Maciej
Górnicki, Krzysztof
Skoczylas, Jacek
Gorajska, Maja
Żuk, Marcin
Rutkowski, Andrzej
Dłubek, Justyna
Powiązania:: https://bibliotekanauki.pl/articles/1393874.pdf
Data publikacji:: 2016
Wydawca:: Index Copernicus International
Tematy:: colorectal cancer
the results of treatment of colon cancer
Opis:: In Poland there there are about 15‑16 thousand cases of colon cancer per year. The health care system allows the treatment of patients with colorectal cancer in highly specialized hospitals, oncology centers and district hospitals. The results of treatment within different reference level differ. The aim of the study was to evaluate the results of surgical treatment of patients with colorectal cancer at a district hospitals compared with the results of highly specialized center. Material and methods. A retrospective study. The material consisted of 171 consecutively operated patients diagnosed with colorectal cancer treated in the Department of Surgery, District Hospital in Wołomin. The control group consisted of 200 patients treated surgically at the Department of General and Colorectal Surgery, University Hospital in Łódź. In both centers, the patients were operated on by surgeons with experience in operations on the large bowel. The demographic data, information on the type of indication (elective vs emergent), and the severity of the disease by AJCC / TNM scale were collected. In the district hospital there were patients with more advanced disease (p <0.001), older (p = 0.0001), and often operated under emergent indication (p = 0.0001). The telephone survey collected data on survival or the date of death of the patient and set the percentage of five-year survival. Results. The proportion of five-year survival in the study group and control group was respectively 46% and 71% (p <0.0001). The percentage of five-year survival among patients undergoing elective procedure in both centers were respectively for Wołomin and Łódź 58% and 73% (p = 0.008). The proportion of 5-year survival among “younger” patients (<70) was respectively in Wołomin and Łódź 64% and 81% (p = 0.004) for “older” patients with (> 70) 50% and 60% (p = 0.6747) Conclusions. Overall results of surgical treatment of patients with colorectal cancer in the district hospital are inferior to treatment results in a highly specialized center. The population treated in the district hospital is statistically significantly different in comparison to patients treated in highly specialized center. The following differences were captured: severity of the disease, age and type of indication (elective vs emergent). The diffrences has an influence on the outcomes. The five years survival for patients > 70 years undergoing elective procedure is not statistically different between the district hospital and highly specialized center.
Źródło:: Polish Journal of Surgery; 2016, 88, 4; 188-195
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 11.

Tytuł:: Prevalence of Cryptosporidium sp. In Patients with Colorectal Cancer
Autorzy:: Sulżyc-Bielicka, Violetta
Kołodziejczyk, Lidia
Jaczewska, Sylwia
Bielicki, Dariusz
Kładny, Józef
Safranow, Krzysztof
Powiązania:: https://bibliotekanauki.pl/articles/1396664.pdf
Data publikacji:: 2012-07-01
Wydawca:: Index Copernicus International
Tematy:: Cryptosporidium
colorectal cancer
Opis:: Parasitic protozoans of the Cryptosporidium genus are intracellular intestinal parasites of mammals, causing cryptosporidiosis. Clinically, cryptosporidiosis manifests as chronic diarrhoea. Individuals with immune disorders, including those with neoplasms, are at risk of symptomatic invasion.The aim of the study was the evaluation of Cryptosporidium sp. prevalence in patients with diagnosed colorectal cancer.Material and methods. The studied group encompassed 87 patients with diagnosed colorectal cancer, undergoing surgery at the Department of General and Oncological Surgery, Pomeranian Medical University, in the years 2009-2010. Immunoenzymatic tests for Cryptosporidium sp. on faeces samples were performed with the use of commercial test kit, ProSpecT®Cryptosporidium Microplate Assay (Remel Inc).Results. The presence of Cryptosporidium sp. was found in 12.6% of studied patients with colorectal cancer. The performed statistical analysis did not reveal any correlation between Cryptosporidium sp. infection and gender, age, neoplasm advancement stage as per Astler-Coller scale, neoplasm differentiation grade, or neoplastic tumour localisation in relation to the splenic flexure.Conclusions. There was found high prevalence of Cryptosporidium sp. in patients with colorectal cancer. It was comparable to the prevalence reported for patients with immune deficiency.
Źródło:: Polish Journal of Surgery; 2012, 84, 7; 348-351
0032-373X
2299-2847
Pojawia się w:: Polish Journal of Surgery
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 12.

Tytuł:: Ocena znaczenia białka YKL-40 jako biomarkera w raku jelita grubego oraz jego powiązań z wybranymi parametrami kliniczno-patologicznymi
Assessment of importance of YKL-40 protein as biomarker in colorectal cancer and its relation to selected clinical and pathological parameters
Autorzy:: Nadbrzeżna-Barczyk, Dorota
Waniczek, Dariusz
Świętochowska, Elżbieta
Nowakowska-Zajdel, Ewa
Copija, Angelika
Raźnikiewicz, Aleksandra
Rykaczewska-Czerwińska, Monika
Lorenc, Zbigniew
Powiązania:: https://bibliotekanauki.pl/articles/1955194.pdf
Data publikacji:: 2021-12-31
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: rak jelita grubego
YKL-40
lokalizacja raka okrężnicy
biomarker nowotworowy
colorectal cancer
colon cancer localization
cancer biomarker
Opis:: WSTĘP: Rak jelita grubego (colorectal cancer – CRC) jest jednym z najczęstszych nowotworów na świecie – odpowiada za 10% rocznej globalnej zapadalności na raka. Przez długi czas może pozostać bezobjawowy i mimo postępu medycyny zbyt często zostaje zdiagnozowany za późno. Białko YKL-40 jest czynnikiem wzrostu stymulującym migrację komórek śródbłonka, odgrywającym rolę w stanach zapalnych oraz nowotworowych. Celem pracy była ocena znaczenia YKL-40 jako biomarkera w CRC oraz określenie powiązań stężeń YKL-40 w surowicy u chorych na CRC z wybranymi parame-trami kliniczno-patologicznymi. MATERIAŁ I METODY: W badaniu prospektywnym, obejmującym 133 osoby powyżej 50 roku życia, oznaczono stężenie białka YKL-40 w surowicy metodą ELISA. Pacjentów podzielono na dwie grupy: 91 osób chorujących na CRC oraz 42 osoby zdrowe. W analizie statystycznej wykorzystano testy t-Studenta dla danych niezależnych, U Manna-Whitneya i regresję logistyczną.WYNIKI: Stężenie YKL-40 w surowicy było znacznie wyższe u chorych na CRC (163 ± 36 μg/l) niż u osób zdrowych (54 ± 20 μg/l; p < 0,0001). U osób z CRC nie wykazano zależności między parametrami klinicznymi, tj. płcią, wiekiem i wskaźnikiem masy ciała (body mass index – BMI), a stężeniem białka YKL-40 w surowicy. U chorych z CRC stężenie YKL-40 w surowicy statystycznie istotnie różniło się we wczesnym i średniozaawansowanym stadium nowotworowym. WNIOSKI: Białko YKL-40 wydaje się obiecującym biomarkerem CRC. Jego stężenie w surowicy jest skorelowane ze stopniem zaawansowania nowotworu zależnie od głębokości nacieku w stosunku do błony podśluzowej i może być czynnikiem rokowniczo niepomyślnym dla tego nowotworu.
INTRODUCTION: Colorectal cancer (CRC) is one of the most common cancers in the world, accounting for 10% of the annual global cancer incidence. This malignant neoplasm can remain asymptomatic for a long time and, despite medical advances, is too frequently diagnosed too late. The YKL-40 protein is a growth factor that stimulates endothelial cell migration, and plays a role in inflammation and neoplasia. The aim of the study was to assess the significance of YKL-40 as a biomarker in CRC and to determine the correlation between the serum YKL-40 levels in CRC patients and selected clinical and pathological parameters. MATERIAL AND METHODS: In a prospective study involving 133 patients over the age of 50, the serum YKL-40 protein level concentration was determined by the ELISA method. The patients were divided into two groups: 91 with CRC and 42 healthy. For the statistical analysis Student's t-test for independent data, the Mann-Whitney U test, and logistics regression were used. RESULTS: The YKL-40 serum concentration was significantly higher in the CRC patients (163 ± 36 μg/l) than the healthy patients (54 ± 20 μg/l; p < 0.0001). There was a statistically significant difference in the serum YKL-40 concentration between the early and intermediate stages of CRC. There was no correlation between the clinical parameters, i.e. sex, age and BMI and the serum YKL-40 protein concentration in the people with CRC. CONCLUSIONS: The YKL-40 protein seems to be a promising CRC biomarker. Its serum concentration is correlated with the stage of the cancer depending on the depth of the growth relative to the submucosa and may be a prognostic factor for an adverse prognosis of this cancer.
Źródło:: Annales Academiae Medicae Silesiensis; 2021, 75; 136-146
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 13.

Tytuł:: Akceptacja choroby u pacjentów z rakiem jelita grubego
Acceptance of disease in patients with colorectal cancer
Autorzy:: Kaleta-Pilarska, Angelina
Powiązania:: https://bibliotekanauki.pl/articles/2047871.pdf
Data publikacji:: 2022-06-03
Wydawca:: Śląski Uniwersytet Medyczny w Katowicach
Tematy:: rak jelita grubego
akceptacja
choroba nowotworowa
colorectal cancer
acceptance
cancer
Opis:: WSTĘP: Ze względu na znaczenie dla zdrowia publicznego problemu, jakim jest poznanie czynników psychologicznych mogących mieć znaczenie dla przebiegu choroby nowotworowej, zrealizowano badanie, którego celem była ocena czę-stości i uwarunkowań akceptacji choroby u pacjentów z rakiem jelita grubego w okresie bezpośrednio poprzedzającym interwencję chirurgiczną. MATERIAŁ I METODY: W badaniu kwestionariuszowym wzięło udział 200 pacjentów z rozpoznanym rakiem jelita grubego. W celu zidentyfikowania ostatecznych predyktorów mających wpływ na akceptację choroby nowotworowej wykonano analizę regresji logistycznej wraz z weryfikującą parametryzacją za pomocą automatycznej selekcji wstecznej. WYNIKI: Nieco ponad połowa badanych (56,5%) z rakiem jelita grubego w okresie bezpośrednio poprzedzającym interwencję chirurgiczną nie akceptuje swojej choroby. Wpływ na akceptację choroby miały zmienne: występowanie raka jelita grubego w rodzinie oraz zadowolenie z opieki medycznej. WNIOSKI: Częstsza akceptacja choroby nowotworowej jelita grubego występuje u pacjentów deklarujących zadowolenie z opieki medycznej oraz u pacjentów, u których rak jelita grubego występował w rodzinie.
INTRODUCTION: Because of the importance of the problem for public health, which is the knowledge of psychological factors that may affect the course of cancer, a study was carried out to assess the frequency and determinants of disease acceptance in patients with colorectal cancer in the period immediately preceding the surgical intervention. MATERIAL AND METHODS: 200 patients with colorectal cancer participated in the questionnaire study. In order to identify the final predictors influencing the acceptance of cancer, logistic regression analysis was performed along with the verification of parametrization using the automatic backward selection method. RESULTS: Slightly more than half of the respondents (56.5%) with colorectal cancer do not accept their disease in the period immediately preceding the surgical intervention. Among the determinants influencing the acceptance of the disease were the following variables: family history of colorectal cancer and satisfaction with medical care. CONCLUSIONS: More frequent acceptance of colorectal cancer occurs in patients who declare satisfaction with medical care and among patients with a family history of colorectal cancer.
Źródło:: Annales Academiae Medicae Silesiensis; 2022, 76; 47-52
1734-025X
Pojawia się w:: Annales Academiae Medicae Silesiensis
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 14.

Tytuł:: Incidence of hereditary non-polyposis colorectal cancer [HNPCC] in the city of Szczecin, north-western Poland
Autorzy:: Kladny, J
Lubinski, J
Powiązania:: https://bibliotekanauki.pl/articles/2046601.pdf
Data publikacji:: 1997
Wydawca:: Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:: incidence
Polska
Szczecin city
hereditary non-polyposis colorectal cancer
colorectal cancer
Opis:: The study population consisted of 140 consecutive colorectal cancer patients, inhabitants of the city of Szczecin, north-west Poland, who were histopathologically diagnosed in the period of 2 years - 1991-1992. Family history was obtained in 124 (88.6%) of patients. A definitive diagnosis of HNPCC was established if requirements of the International Collaborative Group on HNPCC (ICG- HNPCC) were met. Suspected HNPCC were recognised according to criteria described by Ponz de Leon or Mecklin or Kunitomo. HNPCC as defined by International Collaborative Group on HNPCC was identified in 2 (1.6%) families. Suspected HNPCC were recognised in 16.9%, 3.2% and 4.0% of patients if Ponz de Leon or Mecklin or Kunitomo criteria were applied, respectively. In our series in 19 of 124 cases, colorectal carcinomas were diagnosed in patients under 50 years of age. Only in one of these cases, features characteristic of HNPCC other than young age were found which suggests that in our region the frequency of somatic or germ line de novo mutations in genes predisposing to colorectal cancer may be high. Our results suggest that the frequency of HNPCC inherited from ancestors in Poland and other countries is approximately similar and this syndrome is common disease everywhere.
Źródło:: Journal of Applied Genetics; 1997, 38, 1; 103-114
1234-1983
Pojawia się w:: Journal of Applied Genetics
Dostawca treści:: Biblioteka Nauki

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Skocz do pozycji: 15.

Tytuł:: Occurrence of BK Virus and Human Papilloma Virus in colorectal cancer
Autorzy:: Jarzyński, Adrian
Zając, Przemysław
Żebrowski, Remigiusz
Boguszewska, Anastazja
Polz-Dacewicz, Małgorzata
Powiązania:: https://bibliotekanauki.pl/articles/990851.pdf
Data publikacji:: 2017
Wydawca:: Instytut Medycyny Wsi
Tematy:: bkv
hpv
colorectal cancer.
Opis:: Introduction and objective. Colorectal cancer is one of the most common cancers worldwide. In Poland, it is the second most common cancer, regardless of gender. The aim of study was to analyze the incidence of HPV and BKV in the tissue of colorectal cancer and to determine the relationship between the presence of these viruses and the development of this cancer. Materials and method. The experiments were conducted using 50 colorectal cancer tissues collected from histological sections. The clinical material was embedded in paraffin blocks. Next, DNA extraction was performed. Isolates of colorectal cancer tissue were tested for the presence of HPV DNA. BKV DNA was detected by PCR using specific primers and then differentiated from JCV by digestion with BamHI enzyme. Results. In clinical specimens taken from patients with colorectal cancer, HPV DNA was detected in 20% of cases. In 10% of cases the presence of HPV type 18 was confirmed, in the other 90% of the samples HPV type 16 was detected, while the presence of BKV was confirmed in 30% of cases. Coinfection with HPV and BKV was shown in 12% of patients. In one case, BK virus coexisted with HPV type 18, in the remaining 5 cases with HPV type 16. Conclusions. Developing colorectal cancer can show no symptoms, even for many years. This is why it is so important to become familiar with as many etiological factors as possible. The development of many human neoplasms is often initiated by exposure to infectious agents – such as bacterial or viral infections. Similar to the human papillomavirus, the BK virus was detected in clinical specimens. It seems that HPV and BKV infections can contribute to the neoplastic process, which requires detailed studies on a larger group of patients.
Źródło:: Annals of Agricultural and Environmental Medicine; 2017, 24, 3
1232-1966
Pojawia się w:: Annals of Agricultural and Environmental Medicine
Dostawca treści:: Biblioteka Nauki

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