- Tytuł:
- Aktywnosc rzesistkobojcza nowo zsyntetyzowanych pochodnych benzoizotiazolinonu [BIT] in vitro
- Autorzy:
-
Ziomko, I
Kuczynska, E. - Powiązania:
- https://bibliotekanauki.pl/articles/838474.pdf
- Data publikacji:
- 1994
- Wydawca:
- Polskie Towarzystwo Parazytologiczne
- Tematy:
-
rzesistek
pasozyty zwierzat
farmakologia
Trichomonas
badania in vitro
pasozyty czlowieka
choroby inwazyjne
choroby czlowieka
parazytologia
choroby zwierzat
leki
aktywnosc rzesistkobojcza
rzesistkowica - Opis:
- Trichomonacidal activity in vitro of 2 newly synthesized derivatives of benzoizothiazolinon (BIT) in comparison with metronidazole was determined by calculating lethal concentration for 50% trichomonal population (C₅₀). Experiments were carried out on 2 strains of T. vaginalis and 2 strains of T. anseris. Both preparations showed considerably higher trichomonacidal activity than metronidazole. Mean values of trichomonacidal activity of N-morpholinomethyl-1,2-benzoizothiazolinon-3 for T. vaginalis and T. anseris amounted to 885 and 1997 respectively, and were 6 and 8 times higher than those of hydrochloride of N-piperydynomethyloamide of (5-chlor-1,2-benzoizothiazolinon-3ylo-2)-acetic acid. The lowest trichomonacidal activity of hydrochloride of N-piperydynomethylamide of (5-chlor-1,2-benzoizothiazolinon-3ylo-2)-acetic acid was 10-fold higher than that of N-morpholinomethyl-1,2-benzoizothiazolinon-3 and several hundred times lower than metronidazole concentration.
- Źródło:
-
Annals of Parasitology; 1994, 40, 1; 59-64
0043-5163 - Pojawia się w:
- Annals of Parasitology
- Dostawca treści:
- Biblioteka Nauki
Artykuł