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Wyświetlanie 1-13 z 13
Tytuł:
Fabrication and physicochemical properties of pectin/chitosan scaffolds
Autorzy:
Kulikouskaya, V.
Lazouskaya, M.
Agabekov, V.
Powiązania:
https://bibliotekanauki.pl/articles/286177.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
pectin
3D scaffold
degradation
Opis:
Scaffolds from chitosan and its combinations with other polymers are widely used for tissue engineering application. This is due to the favourable biological properties of chitosan such as antimicrobial activity, biocompatibility, biodegradability, cell adhesion and proliferation, etc. The aim of the study was the creation of 3D porous scaffolds based on pectin/chitosan polyelectrolyte complexes and study the influence of components ratio on their physico-chemical properties, as well as degradation behaviour in solutions modelling the media of the human body. Porous “sponge-like” polysaccharide films were produced using freeze-drying technique from gel-like pectin-chitosan polyelectrolyte complexes. The weight ratio of chitosan:pectin in complexes was varied in the range from 1:1 to 1:2. Obtained samples were characterized by infrared spectroscopy and scanning electron microscopy. It has been shown that pectin-chitosan films turned out to have sponge-like structure with highly interconnected pores with the size about 50-300 μm. It has been determined that all samples regardless of the chitosan:pectin ratio possess high swelling properties. The degradation profile of scaffolds in different media was studied. It has been determined that the largest weight loss is observed in water and reaches more than 80% after 1 day, while in NaCl and PBS solutions weight loss is approximately 50-60% after 25 days. For samples with different chitosan:pectin weight ratio, weight loss slightly rise with increasing amount of pectin. It has been shown that mesenchymal stem cells adhered to the surface of obtained pectin:chitosan porous scaffolds in viable state. Hence, it can be served as a potential material for tissue engineering applications.
Źródło:
Engineering of Biomaterials; 2018, 21, 146; 2-7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Physicochemical properties and cytotoxicity of hydrogels based on Beetosan® containing sage and bee pollen
Autorzy:
Tyliszczak, Bożena
Drabczyk, Anna
Kudłacik-Kramarczyk, Sonia
Grabowska, Beata
Kędzierska, Magdalena
Powiązania:
https://bibliotekanauki.pl/articles/1038565.pdf
Data publikacji:
2017
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
hydrogels
cytotoxicity
fibroblasts
chitosan
sage
wettability
Opis:
Currently, increasing attention is being paid to issues related to environmental protection, waste management, as well as to the development of polymers with useful properties. The research presented here involved preparation of hydrogels based on Beetosan® - a chitosan derived from the multi-stage processing of dead bees. Moreover, hydrogels were additionally modified with natural substances - i.e. bee pollen and extract of Salvia officinalis (sage) that are well known for the presence of many compounds with beneficial properties from a medical point of view. Materials have been first obtained by photopolymerization. Then, their surface morphology, wettability and cytotoxicity to selected cell lines have been determined. It can be stated that such combination of Beetosan® hydrogel matrix and the mentioned additives resulted in a preparation of polymers characterized by negative impact on cancer cells. Impact of hydrogels with sage is slightly more intense due to the presence of substances such as ursalic or rosmaric acid that are characterized to have anticancer activity. Such negative impact has not been observed in case of studies using fibroblasts. Furthermore, addition of natural substances into hydrogels resulted in a more homogeneous surface and in the decrease of wettability angle of the tested polymers. It can be concluded that the use of natural-derived reagents and synthesis of polymers using these reagents (as a result of environmentally friendly photopolymerization) yields materials with interesting properties for medical purposes, with particular emphasis on antitumor activity, and without significant negative impact on fibroblasts.
Źródło:
Acta Biochimica Polonica; 2017, 64, 4; 709-712
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Study of the effect of the physicochemical properties of chitosan on its haemostatic activity
Autorzy:
Kadyseva, Oksana V.
Bykov, Vladimir N.
Strelova, Olga Y.
Grebenyuk, Alexander N.
Powiązania:
https://bibliotekanauki.pl/articles/2131504.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
NMR
UV/Vis spectroscopy.
bleeding
chitosan
conformation
haemostasis
Opis:
Chitosan are biopolymers that are actively used for the production of local haemostatic agents. The physicochemical characteristics that determine its biological properties include the molecular weight and the deacetylation degree. However, there is no linear relationship between these parameters and haemostatic activity. The most reliable method of confirming the effectiveness is still in vivo experiments. The ability to initiate haemostasis depends on the conformational transition of chitosan macromolecules. The highest efficiency in vitro was for samples in which the transition of a significant part of the molecules from the ‘rigid rod’ state to the ‘globule’ occurred at physiological pH. It is proposed to expand the list of indicators of chitosan that can be controlled to evaluate the quality of raw materials, related to haemostatic activity, to include the definition of the conformational transition at physiological pH.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 112-120
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Evaluation of physicochemical properties of solid dispersions of bcs class ii substances with chitosan
Autorzy:
Grimling, Bożena
Górniak, Agata
Meler, Jan
Pluta, Janusz
Powiązania:
https://bibliotekanauki.pl/articles/1035366.pdf
Data publikacji:
2012
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
DSC studies
chitosan
dissolution
fenofibrate
solid state lyophilisation
Opis:
The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation by means of freeze-drying at the drug to polymer ratio of 3:7,5:5,7:3. The study revealed a multi-fold increase (from 33 to 57 times) in fenofibrat solubility in the presence of chitosan, which increased with duration of the study and with increasing percentage of the polymer in formulations. DSC examination revealed a possible physical interaction between the drug and the polymer. The degree of lowering of temperature and increased heat effects is correlated with increased solubility of the drug in all the formulations. DSC studies confirmed that fenofibrate is present in solid dispersions in a crystalline form.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2012, 17; 87-94
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The study of physicochemical properties of solid dispersions of ibuprofen in the presence of chitosan
Autorzy:
Grimling, Bożena
Meler, Jan
Szcześniak, Maria
Pluta, Janusz
Górniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1034797.pdf
Data publikacji:
2015
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
dissolution
ibuprofen
solid dispersion
Opis:
The aim of the present study was to increase the solubility of ibuprofen. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Solid dispersion obtained. Ibuprofen was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of ibuprofen and chitosan (1:9. 3:7 and 5:5). Formulations were tested dissolution rate of the ibuprofen. The highest dissolution of ibuprofen, amounting to 12.59%, was observed after 60 minutes from solid dispersion prepared by the evaporation method and 12.18% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 60-fold. XRPD analysis indicates the presence of the ibuprofen in amorphous form in the solid dispersion obtained by the modified solvent evaporation.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2015, 20; 64-72
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The investigation of physicochemical properties of the solid dispersions in the presence polymeric carrier- chitosan
Autorzy:
Grimling, Bożena
Meler, Jan
Pluta, Janusz
Górniak, Agata
Powiązania:
https://bibliotekanauki.pl/articles/1035561.pdf
Data publikacji:
2013
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
DSC
IR studies
chitosan
fenofibrate
physical mixtures
saturation solubility
solid dispersions
Opis:
The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2013, 18, 18; 167-173
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Comparative study on physicochemical properties of alpha-TCP / calcium sulphate dihydrate biomicroconcretes containing chitosan, sodium alginate or methylcellulose
Autorzy:
Czechowska, Joanna
Zima, Aneta
Ślósarczyk, Anna
Powiązania:
https://bibliotekanauki.pl/articles/307328.pdf
Data publikacji:
2020
Wydawca:
Politechnika Wrocławska. Oficyna Wydawnicza Politechniki Wrocławskiej
Tematy:
alpha-tricalcium phosphate
calcium sulphate
chitosan
sodium alginate
methylcellulose
biomicroconcrete
siarczan wapnia
chitozan
alginian sodu
metyloceluloza
Opis:
Recently, the attention has been drawn to complex systems – biomicroconcretes composed of a bone cement matrix and resorbable granules or microspheres. This paper presents novel bone substitutes composed of α-tricalcium phosphate (α-TCP; cement matrix), calcium sulphate dihydrate granules (GCSD; aggregates in biomicroconcrete) and various polymers (chitosan, sodium alginate, methylcellulose) used for the improvement of material properties. The aim of this work was to study α-TCP-GCSD-polymer interactions and to compare the impact of organic additives on the physicochemical properties of biomicroconcretes. Methods: Scanning electron microscopy (SEM), mercury intrusion porosimetry (MIP), X-ray diffractometry (XRD) as well as universal testing machine (INSTRON), Gilmore apparatus and pH/ conduct-meter were used. Results: The chemical bonding between α-TCP matrix and CSD granules resulted in a compressive strength appropriate for low-load bearing applications (7–12 MPa) and clinically relevant setting times (8–33 min). Biomicroconcretes consisting of sodium alginate possessed the highest mechanical strength (12 ± 2 MPa). It has also been found that the dissolution-precipitation reactions of the α-TCP were retarded with the addition of chitosan and acetic acid. This effect was not observed in the case of methylcellulose and sodium alginate. Chemical stability and bioactivity of materials were demonstrated during in vitro studies in simulated body fluid. Conclusions: Materials containing calcium sulphate-based granules were surgically handy, possessed promising physicochemical properties and are supposed to ensure desired macroporosity as well as gradual resorption in vivo. It has been demonstrated that the presence of CSD granules and polymers influenced the physicochemical properties of composites.
Źródło:
Acta of Bioengineering and Biomechanics; 2020, 22, 1; 47-56
1509-409X
2450-6303
Pojawia się w:
Acta of Bioengineering and Biomechanics
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Właściwości fizykochemiczne i funkcjonalne biokompozytów polimerowych
Physicochemical and functional properties of polymer biocomposites
Autorzy:
Wiśniewska-Wrona, Maria
El Fray, Mirosława
Powiązania:
https://bibliotekanauki.pl/articles/947105.pdf
Data publikacji:
2019
Wydawca:
Sieć Badawcza Łukasiewicz - Instytut Chemii Przemysłowej
Tematy:
rany odleżynowe
chitozan
alginian
opatrunek w postaci jednowarstwowej błony
FT-IR
DSC
NMR
bedsores
chitosan
alginate
single layer film wound dressing
Opis:
Otrzymano błony biokompozytowe wytworzone na bazie chitozanu (Chit) i alginianu sodu (Alg) z udziałem substancji leczniczych o działaniu przeciwzapalnym (siarczan cynku) i przeciwbakteryjnym (sulfanilamid). Metodami spektrofotometrii w podczerwieni (FT-IR), magnetycznego rezonansu jądrowego (NMR) oraz różnicowej kalorymetrii skaningowej (DSC) oceniono wpływ zawartości chitozanu i alginianu na budowę chemiczną i temperaturę przemian fazowych biokompozytów. Analiza termiczna wykazała, że dodatek substancji leczniczych do materiałów biokompozytowych wpływa zarówno na obniżenie ich temperatury topnienia, jak i na zmniejszenie entalpii związanej z tą przemianą.
Biocomposite films based on chitosan (Chit) and sodium alginate (Alg) and containing anti-inflammatory (zinc sulfate) and antimicrobial (sulfanilamide) pharmaceutical ingredients were prepared. The effects of variable chitosan and alginate contents on the chemical structure and phase transition temperatures of biocomposites were studied using infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC). Thermal analysis showed that the addition of pharmaceuticals decreased the melting temperature and melting enthalpy of polymer biocomposites.
Źródło:
Polimery; 2019, 64, 1; 23-33
0032-2725
Pojawia się w:
Polimery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Characteristics of physicochemical and rheological properties of chitosan hydrogels based on selected hydroxy acids
Autorzy:
Zavyalova, Olga
Gajewska, Sandra
Dąbrowska-Wisłocka, Dominika
Sionkowska, Alina
Powiązania:
https://bibliotekanauki.pl/articles/2058389.pdf
Data publikacji:
2021
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
chitosan
lactobionic acid
mandelic acid
rheology
FTIR spectra
chitozan
reologia
hydrożele
Opis:
Chitosan is a natural cationic polymer that dissolves in an acidic environment and forms gels. Its properties depend on the degree of deacetylation and molecular weight. It is a bioactive compound with antibacterial and film-forming properties that allow to increase the regenerative capacity of the skin. Moreover, it is biodegradable, biocompatible, non-toxic, and stable. In this research, chitosan was combined with mandelic and lactobionic acids which are characterized by biological activity and low toxicity. This combination not only has a positive effect on the chitosan solubility, but it also allows to obtain new biomaterials whose positive features of the base ingredients are enhanced by their synergistic effect. The obtained hydrogels were assessed regarding the interaction of chitosan and hydroxy acid molecules, and the stability of the resulting structures was examined. The research was performed by using rheological methods and IR spectroscopy. Chitosan hydrogels made with mandelic acid are characterized by higher viscosity values, as compared to hydrogels containing lactobionic acid. The samples of the obtained hydrogels stored for 7 days showed no signs of degradation and their viscosity values were constantly increasing, which proves the ongoing process of creating new bonds between hydroxy acid molecules and chitosan chains. After this time, the hydrogels with mandelic acid revealed higher viscosity values in comparison to hydrogels made with lactobionic acid. Based on the obtained IR spectra, the shifts of the characteristic chitosan bands as a result of interaction with the tested hydroxy acids were analyzed.
Źródło:
Engineering of Biomaterials; 2021, 24, 161; 2--7
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Influence of chitosan molecular weight and degree of deacetylation on membrane physicochemical and separation properties in ethanol dehydration by the vapour permeation process
Autorzy:
Gnus, Małgorzata
Powiązania:
https://bibliotekanauki.pl/articles/1034007.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
chitosan
degree of deacetylation
molecular weight
separation properties
vapour permeation
Opis:
Membranes were prepared using three chitosans with different molecular weights and degrees of deacetylation. The influence of chitosan features on membrane physicochemical properties, i.e. degree of swelling, contact angle and tensile strength, as well as membrane separation properties in ethanol dehydration by the vapour permeation process are discussed. The conducted experiments showed that an increase in the chitosan molecular weight led to an increase in the membrane surface contact angle concomitant with a decrease in the material selectivity coefficient. On the other hand, an increase in the chitosan degree of deacetylation caused a reduction in ethanol and improved the water permeate flux. There was greater selectivity in the test process for membranes prepared from chitosan with the lowest molecular weight.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 79-93
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of biodegradable polysaccharide-protein edible gel coat with antimicrobial properties for food products
Autorzy:
Kuprina, Elena E.
Yakkola, Anastasiya N.
Manuylov, Andrey N.
Kiprushkina, Elena I.
Shestopalova, Irina A.
Demidov, Pavel I.
Powiązania:
https://bibliotekanauki.pl/articles/2131514.pdf
Data publikacji:
2021
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
biodegradable food films and coatings
chitosan
ediblefilms and coatings
environmental protection
formulation
mechanism of formation
physical and mechanical
physicochemical
protein hydrolysate
sensory
sodium alginate
technology
antimicrobial properties
Opis:
Food edible coatings are an important milestone in food production and one of the innovations in food packaging development. This article presents materials on the development of the formulation and technology for the manufacture of a novel composite coating based on sodium alginate, chitosan and protein hydrolysate obtained by the electrochemical method of double extraction from cod processing waste to obtain edible coatings for semi-finished fish products. Furthermore, the physicochemical, physical, mechanical and microbiological properties of this material are described.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2021, 26; 148-161
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Application of gamma radiation and physicochemical treatment to improve the bioactive properties of chitosan extracted from shrimp shell
Autorzy:
Aktar, J.
Hasan, Z.
Afroz, T.
or-Rashid, H.
Pramanik, K.
Powiązania:
https://bibliotekanauki.pl/articles/148197.pdf
Data publikacji:
2017
Wydawca:
Instytut Chemii i Techniki Jądrowej
Tematy:
chitosan
gamma radiation
degree of deacetylation
antimicrobial activity
Opis:
The aim of this study is to exploit a suitable chitosan extraction method from the chitin of indigenous shrimp shells by employing different physicochemical treatments and to improve different bioactive properties of this extracted chitosan (CS) by applying gamma radiation. Chitin was prepared from shrimp shell by pretreatment (deproteination, demineralization and oxidation). Chitosan was extracted from chitin by eight different methods varying different physicochemical parameters (reagent concentration, temperature and time) and assessed with respect to the degree of deacetylation, requirement of time and reagents. The method where chitin was repeatedly treated with 121°C for 30 min with 20 M NaOH, produced the highest degree of deacetylation (DD) value (92%) as measured by potentiometric titration, with the least consumption of time and chemicals, and thus, selected as the best suitable extraction method. For further quality improvement, chitosan with highest DD value was irradiated with different doses (i.e., 5, 10, 15, 20 and 50 kGy) of gamma radiation from cobalt-60 gamma irradiator. As the radiation dose was increased, the molecular weight of the wet irradiated chitosan, as measured by the viscosimetric method, decreased from 1.16 × 105 to 1.786 × 103 , 1.518 × 103 , 1.134 × 103 , 1.046 × 103 and 8.23 × 102 dalton, respectively. The radiation treatment of chitosan samples increased the antimicrobial activity signifi cantly in concentration dependent manner on both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, as determined by the well-diffusion method. Four to fi ve percent wet chitosan treated with a radiation dose range of 5.0–10.0 kGy rendered the highest antimicrobial activity with least energy and time consumption. Solubility, water binding capacity (WBC) and fat binding capacity (FBC) also improved due to irradiation of chitosan.
Źródło:
Nukleonika; 2017, 62, 4; 245-251
0029-5922
1508-5791
Pojawia się w:
Nukleonika
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Development of biodegradable packaging films and edible coatings for food products based on composite materials
Autorzy:
Kuprina, Elena Eduardovna
Yakkola, Anastasiya Nikolaevna
Manuylov, Andrey Nikolaevich
Kabysh, Olesya
Zhirkova, Marina Gavrilyevna
Zhernyakova, Anastasiya Valeryevna
Shmelkova, Mariya Alekseevna
Vitalyevich, Timofeev Sergey
Stepanov, Anatoliy
Powiązania:
https://bibliotekanauki.pl/articles/1034154.pdf
Data publikacji:
2020
Wydawca:
Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
Tematy:
bactericidal properties
biodegradable food films and coatings
chitosan
edible films and coatings
environmental protection
physicochemical
sodium alginate
Opis:
Plastic is undoubtedly the most convenient type of packaging, but at the same time it is not ecologically friendly. The widespread use of packaging materials all over the world makes us think more and more about the harm of plastic to the environment and humans. It does not decompose in natural conditions and accumulates in huge quantities, because it is mostly used as a single-use packaging. Therefore, the development of environmentally friendly biodegradable edible films and coatings is relevant. Edible food packaging is an important step in food production and one of the innovative directions of food packaging development. This article presents materials on the development of the formulation and manufacturing technology of new composite materials based on sodium alginate and chitosan for the production of edible coatings and films. The results of the physical, chemical and bactericidal properties of these materials are presented.
Źródło:
Progress on Chemistry and Application of Chitin and its Derivatives; 2020, 25; 124-131
1896-5644
Pojawia się w:
Progress on Chemistry and Application of Chitin and its Derivatives
Dostawca treści:
Biblioteka Nauki
Artykuł
    Wyświetlanie 1-13 z 13

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