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    Wyświetlanie 1-5 z 5
    Tytuł:
    Fecal lactoferrin, a marker of intestinal inflammation in children with inflammatory bowel disease
    Autorzy:
    Borkowska, Anna
    Liberek, Anna
    Łuczak, Grażyna
    Jankowska, Agnieszka
    Plata-Nazar, Katarzyna
    Korzon, Maria
    Kamińska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039002.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    fecal lactoferrin
    inflammatory bowel disease
    children
    Opis:
    The aim of this study was to analyze the usefulness of fecal lactoferrin in the diagnosis and monitoring of inflammatory bowel disease (IBD) in children. The study included 52 children with IBD (24 with Crohn's disease and 28 with ulcerative colitis) aged between 0.92 and 18 years, and 41 IBD-free controls of similar age. Fecal concentration of lactoferrin was determined with a quantitative immunoenzymatic test. Fecal concentration of lactoferrin in children with IBD was significantly higher than in the controls. The cut-off value of fecal lactoferrin concentration optimally distinguishing between the children with IBD and the controls was identified as 13 μg/g. The sensitivity and specificity of this cut-off value equaled 80.7% and 92.7%, respectively, and its positive and negative prognostic values were 96.8% and 63.3%, respectively. Patients diagnosed with moderate Crohn's disease had significantly higher fecal concentrations of lactoferrin than children with the mild or inactive disease. Similarly, children with moderate ulcerative colitis showed significantly higher fecal concentrations of lactoferrin than individuals with the mild condition. No significant relationship was found between the fecal concentration of lactoferrin and the severity of endoscopic lesions. Patients with IBD and a positive result of fecal occult blood test were characterized by significantly higher concentrations of lactoferrin than the individuals with IBD and a negative result of this test. In conclusion, fecal concentration of lactoferrin seems to be a useful parameter for diagnosis and monitoring of IBD in children.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 3; 541-545
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Coexistence of type 1 diabetes mellitus and spinal muscular atrophy in an 8-year-old girl: a case report
    Autorzy:
    Borkowska, Anna
    Jankowska, Agnieszka
    Szlagatys-Sidorkiewicz, Agnieszka
    Sztangierska, Beata
    Liberek, Anna
    Plata-Nazar, Katarzyna
    Kamińska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039156.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    Spinal muscular atrophy
    diabetes mellitus
    children
    Opis:
    The spinal muscular atrophy is a rare autosomal recessive genetic disease characterized by the progressive loss of muscular strength. In its natural course the disease leads to death. Diabetes mellitus type 1 is an autoimmune metabolic disorder characterized by the disturbed insulin synthesis. This is a case report of an 8-year-old girl suffering from Werdnig Hoffman disease in whom DM1 was diagnosed. The unspecific clinical manifestation and diagnostic difficulties are presented in this paper. To the authors' knowledge, this is the first publication concerning the co-existence of these two medical conditions.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 167-168
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Evaluation of clinical usefulness of serum neopterin determination in children with bacterial infections
    Autorzy:
    Plata-Nazar, Katarzyna
    Luczak, Grażyna
    Liberek, Anna
    Dudzinska-Gehrmann, Julita
    Sznurkowska, Katarzyna
    Landowski, Piotr
    Kaminska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1039150.pdf
    Data publikacji:
    2015
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    neopterin
    children
    urinary tract infections
    Opis:
    Neopterin (NPT) (6-D-erythro-trihydroxypropyl pteridin) is one of the indicators of the immune system activity. Elevated neopterin concentration occurs in diseases mostly involving stimulation of cellular immunity. The determination of neopterin concentration, usually in blood serum and urine but also in many other bodily fluids, has already been applied in many areas of medicine, such as transfusiology, transplantology, oncology, infectious diseases and autoimmunological diseases. Objective. The aim of this work is to evaluate clinical usefulness of serum neopterin determination in children with urinary tract infections of confirmed bacterial etiology. Material. The study involved 56 children with bacterial urinary tract infections - patients of the Clinic of Paediatrics, Paediatric Gastroenterology, Hepatology & Paediatric Nutrition of Medical University of Gdańsk in the years 2012-2013. The control group included 105 healthy children. Results. The values of NPT concentration in blood serum obtained in the group of children with urinary tract infections did not significantly differ from the values obtained in the control group. Conclusions. The determination of neopterin concentration in children with bacterial urinary tract infections is not a clinically useful parameter.
    Źródło:
    Acta Biochimica Polonica; 2015, 62, 1; 133-137
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Graves disease, celiac disease and liver function abnormalities in a patient - clinical manifestation and diagnostic difficulties
    Autorzy:
    Góra-Gębka, Magdalena
    Woźniak, Małgorzata
    Cielecka-Kuszyk, Joanna
    Korpal-Szczyrska, Maria
    Sznurkowska, Katarzyna
    Zagierski, Maciej
    Jankowska, Irena
    Plata-Nazar, Katarzyna
    Kamińska, Barbara
    Liberek, Anna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039288.pdf
    Data publikacji:
    2014
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    autoimmune disease
    Graves' disease
    celiac disease
    liver abnormalities
    children
    Opis:
    Autoimmune diseases due to probable common pathogenesis tend to coexist in some patients. Complex clinical presentation with diverse timing of particular symptoms and sophisticated treatment with numerous side effects, may cause diagnostic difficulties, especially in children. The paper presents diagnostic difficulties and pitfalls in a child with Graves' disease, celiac disease and liver function abnormalities.
    Źródło:
    Acta Biochimica Polonica; 2014, 61, 2; 281-284
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Immune response against HtrA proteases in children with cutaneous mastocytosis
    Autorzy:
    Renke, Joanna
    Kędzierska-Mieszkowska, Sabina
    Lange, Magdalena
    Nedoszytko, Bogusław
    Liberek, Anna
    Plata-Nazar, Katarzyna
    Renke, Marcin
    Wenta, Tomasz
    Żurawa-Janicka, Dorota
    Skórko-Glonek, Joanna
    Lipińska, Barbara
    Powiązania:
    https://bibliotekanauki.pl/articles/1038382.pdf
    Data publikacji:
    2018
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    HtrA proteases
    children
    cutaneous mastocytosis
    mast cells
    Opis:
    Mast cells play an important role in both, the innate and adaptive immunity, however, clonal proliferation of abnormal mast cells in various organs leads to mastocytosis. A skin variant of the disease, cutaneous mastocytosis (CM) is the most frequent form of mastocytosis in children. HtrA proteases are modulators of important cellular processes, including cell signaling and apoptosis, and are related to development of several pathologies. The above and the observation that mast cells constitutively release the HtrA1 protein, prompted us to investigate a possible involvement of the HtrA proteins in pediatric CM. Levels of the serum autoantibodies (IgG) against the recombinant HtrA proteins (HtrA1-4) in children with CM (n=36) and in healthy controls (n=62) were assayed. Anti-HtrA IgGs were detected using enzyme linked immunosorbent assay (ELISA) and Western-blotting. In the CM sera, levels of the anti-HtrA1 and anti-HtrA3 autoantibodies were significantly increased when compared to the control group, while the HtrA protein levels were comparable. No significant differences in the anti-HtrA2 IgG level were found; for the anti-HtrA4 IgGs lower levels in CM group were revealed. In healthy children, the IgG levels against the HtrA1, -3 and -4 increased significantly with the age of children; no significant changes were observed for the anti-HtrA2 IgG. Our results suggest involvement of the HtrA1 and HtrA3 proteins in pediatric CM; involvement of the HtrA4 protein is possible but needs to be investigated further. In healthy children, the autoantibody levels against HtrA1, -3 and -4, but not against HtrA2, increase with age.
    Źródło:
    Acta Biochimica Polonica; 2018, 65, 3; 471-478
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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