- Tytuł:
- Role of Chlamydia pneumoniae in the pathogenesis of hypertrophy and adenoid tissue inflammation in children
- Autorzy:
-
Bielicka, Anna
Zielnik-Jurkiewicz, Beata
Podsiadły, Edyta
Prochorec-Sobieszek, Monika
Rogulska, Joanna
Demkow, Urszula - Powiązania:
- https://bibliotekanauki.pl/articles/1398597.pdf
- Data publikacji:
- 2016
- Wydawca:
- Index Copernicus International
- Tematy:
-
chlamydia pneumoniae
adenoid
PCR
child - Opis:
- Objective. A tropism to epithelial cells and lymphocytes, an inhibition of apoptosis in host cells, an ability to occurrence in persistent form resistant to antibiotic treatment are the features of Chlamydia pneumoniae, which can have connection with chronic inflammation of an adenoid tissue and adenoid hypertrophy. This study aimed to (1) detect the C. pneumoniae in an adenoid in children undergoing adenoidectomy, (2) estimate a connection between C. pneumoniae occurrence and the size of adenoid, (3) demonstration in which of adenoid cells C. pneumoniae occurs most often. Material and methods. The examined group consisted of 200 children aged from 2 to 16 years (mean age 6,4) undergoing adenoidectomy. In all children during qualification for adenoidectomy a fiberoscopic examination of the nasopharynx was performed. A part of removed adenoid tissue was analysed by real-time PCR for C. pneumoniae. Adenoids from children with positive PCR examination and from 10 children with negative PCR examination were examined using immunohistochemistry (IHC). Results. C. pneumoniae in the adenoid was present in 5,5% children. Positive results were obtained most frequently (24,14%, 7/29) in the eldest group (10-16 years). A statistical analysis demonstrated the correlation between C. pneumoniae occurrence in an adenoid tissue and the size of adenoid. In immunohistochemistry C. pneumoniae was found the most frequently in lymphocytes and in epithelial cells. Conclusions. A presence of C. pneumoniae in lymphocytes and epithelial cells of the adenoid first of all in older children with adenoid hypertrophy confirms the participation of this bacteria in adenoid pathology.
- Źródło:
-
Polish Journal of Otolaryngology; 2016, 70, 5; 7-12
0030-6657
2300-8423 - Pojawia się w:
- Polish Journal of Otolaryngology
- Dostawca treści:
- Biblioteka Nauki
Artykuł