- Tytuł:
- Solution blow spun poly-L-lactic acid/ceramic fibrous composites for bone implant applications
- Autorzy:
-
Wojasiński, Michał
Ciach, Tomasz - Powiązania:
- https://bibliotekanauki.pl/articles/2086798.pdf
- Data publikacji:
- 2021
- Wydawca:
- Polska Akademia Nauk. Czytelnia Czasopism PAN
- Tematy:
-
solution blow spinning
composite fibres
submicron fibres
nanofibres
poly-L-lactic acid
ceramic particles
bone implants
wirowanie z rozdmuchiwaniem roztworu
włókna kompozytowe
włókna submikronowe
nanowłókna
kwas poli-L-mlekowy
cząstki ceramiczne
implanty kostne - Opis:
- Every bone implant to work correctly after implantation needs to integrate with the surrounding bone. To enhance such a process, called osseointegration, various techniques of implant surface modification emerged. One of the approaches is based on the deposition of nano- and submicron materials on the implant surface. This paper presents a solution blow spinning process for producing poly-L-lactic acid (PLLA)/ceramic fibrous composites designed to be deposited directly onto orthopaedic implants prior to implantation to increase osseointegration. We produced plain PLLA fibrous materials for comparison, and fibrous composite materials with -tricalcium phosphate (TCP), hydroxyapatite nanoparticles (nHAp) and hydroxyapatite nanoparticles modified with lecithin (nHAp-LE). We performed the structural analysis of produced materials with scanning electron microscopy, gravimetric determination of porosity, and water contact angle measurement. We also used infrared spectroscopy, Alizarin Red S staining, and cytotoxicity evaluation to conclude that PLLA/nHAp-LE composite material shows the most promising properties to be applied as surface modification of bone implants. To visualise fibrous composite deposition on implants, we used two models: titanium plate and stainlesssteel bolt. Thus, we showed that the solution blow spun materials can be used for surface modification of orthopaedic implants.
- Źródło:
-
Chemical and Process Engineering; 2021, 42, 3; 275--289
0208-6425
2300-1925 - Pojawia się w:
- Chemical and Process Engineering
- Dostawca treści:
- Biblioteka Nauki
Artykuł