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Tytuł:
A novel member of the thermolysin family, cloning and biochemical characterization of metalloprotease from Staphylococcus pseudintermedius
Autorzy:
Wladyka, Benedykt
Bista, Michal
Sabat, Artur
Bonar, Emilia
Grzeszczuk, Sabina
Hryniewicz, Waleria
Dubin, Adam
Powiązania:
https://bibliotekanauki.pl/articles/1040710.pdf
Data publikacji:
2008
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
staphylococcus
calcium
metalloprotease
pathogen
Opis:
Thermolysins constitute a family of secreted bacterial metalloproteases expressed, among others, by several pathogens. Strains of Staphylococcus pseudintermedius isolated from diseased dogs and judged as protease-positive, by skim milk agar plate culture, were investigated for protease content. No proteolytic activity was detected when the bacteria were grown in regular liquid media. Unexpectedly, supplementation of the medium with calcium ions resulted in expression of a metalloprotease and profound changes in the profile of extracellular proteins. On the basis of homology to other staphylococcal metalloproteases, the nucleotide sequence of the gene encoding this protease (Pst) and its flanking regions was determined. The full-length pst codes for a protein with an open reading frame of 505 amino acids. The internal region contains the HEXXH catalytic domain that is conserved in members of the thermolysin family. Regardless of the presence of calcium in the medium, the expression of the protease gene was of the same intensity. This suggests that regulation of the metalloprotease production by calcium ions is at a post-transcriptional level. Isolates of S. pseudintermedius exhibit a proteolytic phenotype due to the metalloprotease expression, however only in presence of calcium ions, which most probably stabilize the structure of the protease.
Źródło:
Acta Biochimica Polonica; 2008, 55, 3; 525-536
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Age-dependent changes in the calcium concentration in womens bones and teeth
Autorzy:
Fischer, A.
Brodziak-Dopierala, B.
Stojko, J.
Powiązania:
https://bibliotekanauki.pl/articles/1192510.pdf
Data publikacji:
2020
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
calcium
bones
teeth
AAS
Opis:
The inorganic part of bone tissue is mainly composed of Ca. In adult people, the resorption processes lead to the removal of minerals from calcified tissues. Women’s bodies are particularly vulnerable to a decrease in the concentration of Ca because the osteolysis processes that occur with age are compounded by hormonal changes during the menopause. The aim of the study was to determine the age-dependent concentration of Ca in the bones and teeth of adult women. The object of the research was calcified tissues bones and teeth (n=323). Samples were taken from women aged 26 - 85 years (mean: 55.7 years), living in Poland, in the Silesian Province. Samples were submitted to wet microwave mineralization (spectrally pure nitric acid). The Ca concentration in teeth and bones was determined with the AAS method. The concentration of Ca in the tested samples of calcified tissues from women aged 26 - 85 years was 10.1‑32.0%, and the average concentration was 16.7±3.5% in bones and 22.2±4.7% in teeth. The calcified tissues, from both bones and teeth, show a progressive decrease in the Ca concentration that occurs as women age. The decreasing level of Ca in bone and teeth was statistically significant (p<0.05). There was a difference in what age calcium is released from bones and teeth. The research showed that a decrease in the Ca concentration in bone tissue occurs earlier than it happens in teeth (about 10 years). The decrease in the Ca concentration in calcified tissues of teeth was slight greater than in bones, indicating slightly greater mobilization of Ca from the tissues of teeth.
Źródło:
Journal of Elementology; 2020, 25, 4; 1319-1331
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Surfactant-assisted fabrication and evaluation of macroporous calcium phosphate bone cements
Autorzy:
Cichoń, E.
Zima, A.
Ślósarczyk, A.
Powiązania:
https://bibliotekanauki.pl/articles/286139.pdf
Data publikacji:
2018
Wydawca:
Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie. Polskie Towarzystwo Biominerałów
Tematy:
bone cements
calcium
phosphate
Źródło:
Engineering of Biomaterials; 2018, 21, 148; 56
1429-7248
Pojawia się w:
Engineering of Biomaterials
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of progesterone on oxytocin-stimulated intracellular Ca2plus mobilisation and prostaglandin secretion in porcine endometrium
Autorzy:
Kotwica, G.
Oponowicz, A.
Kurowicka, B.
Franczak, A.
Bogacka, I.
Powiązania:
https://bibliotekanauki.pl/articles/31688.pdf
Data publikacji:
2010
Wydawca:
Polska Akademia Nauk. Czytelnia Czasopism PAN
Tematy:
progesterone
oxytocin
intracellular calcium
calcium
prostaglandin secretion
porcine endometrium
endometrium
pregnancy
pig
hormone
Opis:
We have studied in the porcine endometrium the expression of oxytocin receptor (OTR) mRNA and the effect of progesterone (P₄) on oxytocin/oxytocin receptor (OT/OTR) function concerning intracellular Ca²⁺mobilisation ([Ca²⁺]i), prostaglandin F2α (PGF2α) and E2 (PGE2; PG) secretion. Tissue was taken from cyclic and early pregnant pigs (days 14-16). A higher expression of OTR mRNA (P<0.05) was observed in the endometrium of cyclic than pregnant pigs. The stimulatory (P<0.05) effect of OT (10⁻⁷ M) on [Ca²⁺]i mobilisation was noticed within 15-60 s and 30-60 s in endometrial stromal cells of cyclic and pregnant pigs, respectively. In the presence of P₄ (10⁻⁵ M) basal and OT-stimulated [Ca²⁺]i concentrations decreased in stromal cells during luteolysis and pregnancy. In stromal cells P₄ delayed mobilisation of [Ca²⁺]i in response to OT by 15 s during luteolysis and had no effect during pregnancy. In cyclic and pregnant epithelial cells OT stimulated mobilisation of [Ca²⁺]i in 45 s and 60 s, respectively. Oxytocin increased (P<0.05) PGF2α secretion during luteolysis and pregnancy and PGE2 during luteolysis from endometrial slices. Progesterone did not inhibit this stimulatory effect. During luteolysis OT increased (P<0.05) PGF2α in epithelial and stromal cells and PGE2 secretion in epithelial cells. In the presence of P₄ this effect of OT was reduced only in stromal cyclic cells (6 h culture). The presence of P₄ decreased the effect of OT on [Ca²⁺]i mobilisation only in stromal cells. We found that, in most conditions, P₄ did not inhibit the OT-stimulated secretion of PG in the porcine endometrium.
Źródło:
Polish Journal of Veterinary Sciences; 2010, 13, 4
1505-1773
Pojawia się w:
Polish Journal of Veterinary Sciences
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Triggering of erythrocyte membrane blebbing by ciprofloxacin
Autorzy:
Shabir, Kashif
Jilani, Kashif
Zbidah, Mohanad
Riaz, Muhammad
Bibi, Ismat
Asghar, Asma
Powiązania:
https://bibliotekanauki.pl/articles/895372.pdf
Data publikacji:
2019-10-30
Wydawca:
Polskie Towarzystwo Farmaceutyczne
Tematy:
oxidative stress
calcium
cell size
Opis:
An extensively used fluoroquinolone antibiotic ciprofloxacin shows a broad-spectrum antibacterial activity against both gram-positive and gram-negative strains. It works mainly by the inhibition of DNA gyrase and topoisomerase IV which results in impaired DNA replication leading towards microbial cell death. Eryptosis is an alternative term used for suicidal erythrocyte death. In current study, eryptotic effect of ciprofloxacin was investigated by exposing erythrocytes for 48 hours to the different concentrations (45-90µM) of ciprofloxacin. The experimental work related to the investigation of eryptosis was done by cell size measurement and confirmation of calcium role in membrane blebbing. As a possible mechanism of eryptosis, oxidative stress induced by ciprofloxacin was determined by catalase, glutathion peroxidase and superoxide dismutase activities measurement. Similarly, necrotic effect of ciprofloxacin was also illustrated by hemolysis measurement. Results of our study revealed that the therapeutical doses of ciprofloxacin may induce oxidative stress by significant decrease in superoxide dismutase, catalase and glutathione peroxidase activities as well as induce eryptosis, featured by erythrocytes membrane blebbing and hemolysis.
Źródło:
Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 5; 901-906
0001-6837
2353-5288
Pojawia się w:
Acta Poloniae Pharmaceutica - Drug Research
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Vitamin C decreases intracellular calcium level in human lymphoid cells
Autorzy:
Ozturk, G.
Mulholland, C.W.
Hannigan, B.M.
Powiązania:
https://bibliotekanauki.pl/articles/70935.pdf
Data publikacji:
2001
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
intracellular calcium
vitamin C
calcium
ascorbic acid
man
lymphocyte
lymphoid cell
leucocyte
antioxidative enzyme
Źródło:
Journal of Physiology and Pharmacology; 2001, 52, 2
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
The effect of chronic exercise on a biomarker of bone resorption in healthy adults
Autorzy:
Yusni, Yusni
Rahman, Safrizal
Powiązania:
https://bibliotekanauki.pl/articles/551546.pdf
Data publikacji:
2019
Wydawca:
Stowarzyszenie Przyjaciół Medycyny Rodzinnej i Lekarzy Rodzinnych
Tematy:
exercise
calcium
bone resorption
adult
Opis:
Background. Long-term exercise contributes to the inhibition of osteoblast cell activity and to the decrease of bone resorption. Objectives. The research objective was to analyze the chronic effect of regular, long-term physical activity and physical inactivity on carboxyterminal collagen cross-linking telopeptide levels (CTx) and calcium levels in healthy adults. Material and methods. This study was a prospective cohort study. Fifty-four men and women, aged 17–26 years, were divided into 2 groups of 27 people each: exercise and non-exercise. This research was carried out from April 2015 to April 2016 at the Faculty of Medicine, Syiah Kuala University, Aceh, Indonesia. Bone resorption can be determined by measuring the carboxyterminal cross-linking telopeptide of collagen (CTx). The data were analyzed using Student’s t-test and regression correlation analysis with a significance level of 5%. Results. The highest levels of CTx were found in the non-exercise group; the lowest levels of CTx were in the exercise group (1.6 ng/mL and 0.30 ng/mL, respectively). This difference in CTx levels between groups was statistically significant (0.52 ± 0.22 ng/mL vs 0.72 ± 0.28 ng/mL; p = 0.005). Calcium was significantly higher in the exercise group than in the non-exercise one (9.67 ± 0.30 vs 9.01 ± 0.21 mg/dl; p = 0.006). There was a negative correlation between calcium levels and CTx in the exercise group (r = 0.038; p = 0.001). Conclusions. Regular exercise led to lower CTx levels and increased calcium levels. The increase in calcium is an effect of the decrease in CTx in healthy adults. Regular exercise decreases bone resorption and increases bone calcium
Źródło:
Family Medicine & Primary Care Review; 2019, 3; 270-276
1734-3402
Pojawia się w:
Family Medicine & Primary Care Review
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Polarograficzne mikrooznaczanie wapnia w surowicy krwi
Polarograficheskoe mikrooboznachenie kalcja v syvorodke krovi
Polarographic microdetermination of calcium in blood serum
Autorzy:
Brzezinska, Z.
Szyszko, E.
Powiązania:
https://bibliotekanauki.pl/articles/871929.pdf
Data publikacji:
1962
Wydawca:
Narodowy Instytut Zdrowia Publicznego. Państwowy Zakład Higieny
Tematy:
krew
surowica krwi
wapn
zawartosc wapnia
oznaczanie
blood
blood serum
calcium
calcium accumulation
determination
Źródło:
Roczniki Państwowego Zakładu Higieny; 1962, 13, 2
0035-7715
Pojawia się w:
Roczniki Państwowego Zakładu Higieny
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Tlenek wapnia – metoda oznaczania
Autorzy:
Surgiewicz, J.
Powiązania:
https://bibliotekanauki.pl/articles/138500.pdf
Data publikacji:
2012
Wydawca:
Centralny Instytut Ochrony Pracy
Tematy:
wapń
tlenek wapnia
metoda analityczna
narażenie zawodowe
calcium
calcium oxide
analytical method
occupational exposure
Opis:
Metoda polega na pobraniu tlenku wapnia na filtr membranowy w celu osadzenia na nim związku zawartego w powietrzu, następnie mineralizacji filtra stężonym kwasem azotowym i oznaczeniu wapnia w roztworze przygotowanym do analizy metodą absorpcyjnej spektrometrii atomowej z zastosowaniem płomienia powietrze-acetylen. Oznaczalność metody wynosi 0,12 mg/m3.
This method is based on stopping selected calcium oxide on a membrane filter, mineralizing the sample with concentrated nitric acid and preparing the solution for analysis in diluted nitric acid. Calcium oxide in the solution is determined as calcium with flame atomic absorption spectrometry. The detection limit for calcium oxide in this method is 0.12 mg/m3.
Źródło:
Podstawy i Metody Oceny Środowiska Pracy; 2012, 1 (71); 129-133
1231-868X
Pojawia się w:
Podstawy i Metody Oceny Środowiska Pracy
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Dietary Pattern and its Relationship Between Bone Mineral Density in Girls and Boys with Cystic Fibrosis – preliminary report
Sposób żywienia i jego związek z gęstością mineralną kości u dziewcząt i chłopców z mukowiscydozą
Autorzy:
Sands, Dorota
Mielus, Monika
Umławska, Wioleta
Lipowicz, Anna
Oralewska, Beata
Walkowiak, Jarosław
Powiązania:
https://bibliotekanauki.pl/articles/1032977.pdf
Data publikacji:
2015
Wydawca:
Wydawnictwo ALUNA
Tematy:
adolescents
calcium
densitometry
nutrition
vitamin D
Opis:
Background: Nutrition influence on cystic fibrosis (CF) patients survival is well documented and dietary therapy is one of basic elements of their treatment. Prolonged survival of CF patients might yet emerge comorbidities, which include bone mineral disease. The aim: The assessment of the dietary pattern and its relationship between bone density in boys and girls with cystic fibrosis. Material and methods: 89 patients aged 10-18 years from 3 Polish CF Centres were included into the study. To obtain a knowledge about quality of diet, a 3-day food record was assessed and percent of recommended for CF patients intake of energy, protein, carbohydrates, fat, vitamin D3, calcium, phosphorus was counted. Bone mineral density (BMD) in lumbar spine (L1-L4) was measured and expressed as a Z-score. To assess nutritional status, anthropometric measurements was evaluated (body weight, height and BMI). Descriptive methods, Mann-Whitney test, T-Student test, Spearman correlation and one-way ANOVA were used for statistical analyses. Results: The patients with cystic fibrosis did not meet specific for CF nutritional guidelines. A deficiency in recommended intake was observed in energy (88%), protein (82%), calcium (78%) and vitamin D3 (71%). The intake of phosphorus was higher than recommended (142%). A nutritional status was significantly reduced, as compared with the reference group (p<0.001). Boys characterized significantly lower body weight (p=0.019) and height (p=0.036) than girls as well as worse caloric (p=0.023) and carbohydrates intake (p=0.005). However, girls had reduced vitamin D3 content in their diet (p<0.001). The bone mineral density in the whole group was reduced and Z-score amounted to -0.95±1.17. Tendency to decreasing of BMD with age was observed. BMI showed important correlation with bone mineral density both in girls (p<0.001) and in boys (p=0.020). Conclusion: CF patients do not follow specific for them dietary recommendations and essential differences were observed between girls and boys. Nutritional status (BMI) showed correlation with bone mineral density in CF patients. Therefore intensive nutritional therapy according to recommendations is needed.
Wprowadzenie: Wpływ żywienia na długość życia chorych z mukowiscydozą (ang. Cystic Fibrosis − CF) jest dobrze udokumentowany, a postępowanie dietetyczne jest jednym z podstawowych elementów leczenia pacjentów z CF. Systematyczne wydłużanie się wieku przeżycia chorych może powodować ujawienie się niedoborów żywieniowych prowadzących do chorób towarzyszących, jakimi są m.in. zaburzenia w gospodarce mineralnej kości. Cel: Celem pracy była ocena sposobu żywienia dziewcząt i chłopców z mukowiscydozą i jego związku z gęstością mineralną kości. Materiał imetody: Do badania włączono 89 pacjentów wwieku 10-18 lat. Wcelu ustalenia jakości diety, oceniono sposób żywienia za pomocą zapisu 3-dniowych jadłospisów, obliczając procent realizacji zapotrzebowania zgodnie z rekomendacjami opracowanymi dla pacjentów z mukowiscydozą. Dotyczyło to pokrycia zapotrzebowania kalorycznego, białka, tłuszczu, węglowodanów, witaminy D3, wapnia i fosforu. Oceniono gęstość mineralną kości (Bone Mineral Density − BMD) w odcinku lędźwiowym (L1-L4). Wynik wyrażono, jako wartość standaryzowaną Z-score. W celu określenia stanu odżywienia dokonano pomiarów antropometrycznych (masa i wysokość ciała oraz BMI). Wykonano następujące obliczenia statystyczne: analizy opisowe, test Manna-Whitneya, test t-Studenta, korelację Spearmana, oraz jednoczynnikową analizę wariancji ANOVA. Wyniki: Badani pacjenci nie spełniali opracowanych dla chorych na mukowiscydozę zaleceń żywieniowych. W diecie zaobserwowano niedobory energii (88% normy), białka (82%), wapnia (78%) oraz witaminy D3 (71%). Wykazano nadmierne spożycie fosforu (142%). Stan odżywienia (parametry antropometryczne) badanej grupy był obniżony i w sposób statystycznie istotny różnił się od grupy referencyjnej (p<0,001). Chłopcy charakteryzowali się znacznie niższą masą ciała (p=0,019) iwysokością (p=0,036) niż dziewczęta, a także niższą kalorycznością diety (p=0,023) oraz zawartością węglowodanów (p=0,005). Dietę dziewcząt cechowała mniejsza zawartość witaminy D3 w diecie (p<0,001) w porównaniu do chłopców. Średnia wartość gęstości mineralnej kości w całej grupie była obniżona i wynosiła -0,95±1,17. Zaobserwowano tendencję do obniżania się BMD wraz z wiekiem. Stan odżywienia wyrażony jako BMI wykazał statystycznie istotną korelację z gęstością mineralną kości, zarówno u dziewcząt (p<0,001), jak i u chłopców (p=0,020). Wnioski: Pacjenci z CF nie przestrzegali opracowanych dla nich zaleceń dietetycznych. Zaobserwowano istotne różnice między dziewczętami i chłopcami. Stan odżywienia (BMI), wykazał korelację z gęstością mineralną kości (BMD), co wymaga intensywnej terapii żywieniowej, zgodnie z opracowanymi rekomendacjami.
Źródło:
Developmental Period Medicine; 2015, 1; 105-113
1428-345X
Pojawia się w:
Developmental Period Medicine
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Analysis of factors affecting the development of hypocalcaemia after multinodular goitre surgery
Autorzy:
Papaj, Piotr
Kozieł, Sławomir
Mrowiec, Sławomir
Powiązania:
https://bibliotekanauki.pl/articles/1393196.pdf
Data publikacji:
2017
Wydawca:
Index Copernicus International
Tematy:
thyroidectomy
hypocalcemia
calcium
TSH
multinodular goiter
Opis:
Introduction: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. In this article, we wish to present an analysis of the results obtained in the control group, focusing on the predicative factors which determine the development of postoperative hypocalcaemia. Obtained results: The rate of postoperative biochemical hypocalcaemia development was significantly higher in the group of patients, where the preoperative calcium concentration was lower than 2,4 mmol/l. In that group, the development of biochemical hypocalcaemia was observed in 93,7% of cases (30 out of 32 patients), in comparison with 65,3% (17 out of 26) in the group of higher preoperative concentration of calcium. The highest risk of occurrence of postoperative hypocalcaemia was borne by the total thyroidectomy, while the lowest one by the subtotal thyroid lobectomy of one lobe only. Conclusions: A higher preoperative concentration of calcium in blood serum is related to the lower rate of occurrence of postoperative biochemical hypocalcaemia. However, no such correlation was revealed in the case of postoperative symptomatic hypocalcaemia. Lack of correlation was determined between the preoperative concentration of TSH and FT4 in blood serum and the rate of occurrence of postoperative hypocalcaemia, both symptomatic and asymptomatic. The performed statistics did not reveal a relation between the postoperative hypocalcaemia and the duration of the surgery, but a significant correlation was stated with the scope of the performed surgery. Revealing a relation between the rate of occurrence of postoperative hypocalcaemia and the experience of the surgeon performing the surgery was not successful.
Źródło:
Polish Journal of Surgery; 2017, 89, 2; 26-30
0032-373X
2299-2847
Pojawia się w:
Polish Journal of Surgery
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Free intracellular calcium [(CA2plus)i] in opioid sensitive cells of the porcine anterior pituitary
Autorzy:
Szafranska, B.
Tilton, J.E.
Powiązania:
https://bibliotekanauki.pl/articles/69614.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Fizjologiczne
Tematy:
naloxone
pig
anterior pituitary
intracellular calcium
calcium
opioid
hypothalamic hormone
gonadotrophin releasing hormone
in vitro
Źródło:
Journal of Physiology and Pharmacology; 2000, 51, 3
0867-5910
Pojawia się w:
Journal of Physiology and Pharmacology
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Toxicological and cytophysiological aspects of lanthanides action.
Autorzy:
Pałasz, Artur
Czekaj, Piotr
Powiązania:
https://bibliotekanauki.pl/articles/1044234.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
gadolinium
cytochrome P450.
calcium
lanthanides
metals
Opis:
Lanthanides, also called rare-earth elements, are an interesting group of 15 chemically active, mainly trivalent, f-electronic, silvery-white metals. In fact, lanthanides are not as rare as the name implies, except for promethium, a radioactive artificial element not found in nature. The mean concentrations of lanthanides in the earth's crust are comparable to those of life-important elements like iodine, cobalt and selenium. Many lanthanide compounds show particular magnetic, catalytic and optic properties, and that is why their technical applications are so extensive. Numerous industrial sources enable lanthanides to penetrate into the human body and therefore detailed toxicological studies of these metals are necessary. In the liver, gadolinium selectively inhibits secretion by Kupffer cells and it decreases cytochrome P450 activity in hepatocytes, thereby protecting liver cells against toxic products of xenobiotic biotransformation. Praseodymium ion (Pr3+) produces the same protective effect in liver tissue cultures. Cytophysiological effects of lanthanides appear to result from the similarity of their cationic radii to the size of Ca2+ ions. Trivalent lanthanide ions, especially La3+ and Gd3+, block different calcium channels in human and animal cells. Lanthanides can affect numerous enzymes: Dy3+ and La3+ block Ca2+-ATPase and Mg2+-ATPase, while Eu3+ and Tb3+ inhibit calcineurin. In neurons, lanthanide ions regulate the transport and release of synaptic transmitters and block some membrane receptors, e.g. GABA and glutamate receptors. It is likely that lanthanides significantly and uniquely affect biochemical pathways, thus altering physiological processes in the tissues of humans and animals.
Źródło:
Acta Biochimica Polonica; 2000, 47, 4; 1107-1114
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Smooth muscle actomyosin promotes Ca2+-dependent interactions between annexin VI and detergent-insoluble glycosphingolipid-enriched membrane domains.
Autorzy:
Babiychuk, Victoria
Draeger, Annette
Babiychuk, Eduard
Powiązania:
https://bibliotekanauki.pl/articles/1044291.pdf
Data publikacji:
2000
Wydawca:
Polskie Towarzystwo Biochemiczne
Tematy:
annexins
calcium
rafts
smooth muscle
cell membrane
Opis:
The mechanical link coupling cytoskeletal and contractile proteins to the sarcolemma of smooth muscle cells is essential for transmitting tension from the cell's interior to exterior. In addition to the well-characterized actin-integrin associations present in adhaerens junctions, our recent work has postulated the existence of a reversible annexin-dependent membrane-cytoskeleton complex, forged in response to a rise in intracellular Ca2+ concentration following smooth muscle cell stimulation (Babiychuk et al., J. Biol Chem. 1999, 274, 35191-35195). Detailed biochemical characterization of the interactions responsible for the formation of this complex revealed that annexins II and VI interact with actomyosin, or detergent-insoluble glycosphingolipid-enriched membrane domains (rafts) purified from smooth muscle, in a concentration- and Ca2+-dependent manner. Annexin II interacted with lipid rafts with high Ca2+-sensitivity, while for annexin VI this interaction required non-physiologically high concentrations of free Ca2+. However, the Ca2+-sensitivity of the latter interaction strongly increased in the presence of purified smooth muscle actomyosin. The detailed biochemical analysis of the interactions occurring between annexin II, annexin VI, actomyosin and rafts suggests that annexins regulate sarcolemmal organization during smooth muscle cell contraction.
Źródło:
Acta Biochimica Polonica; 2000, 47, 3; 579-589
0001-527X
Pojawia się w:
Acta Biochimica Polonica
Dostawca treści:
Biblioteka Nauki
Artykuł
Tytuł:
Content of calcium and phosphorus and the Ca:P ratio is selected species of leguminous and herbaceous plants
Autorzy:
Grzegorczyk, S.
Alberski, J.
Olszewska, M.
Grabowski, K.
Bałuch-Małecka, A.
Powiązania:
https://bibliotekanauki.pl/articles/1190201.pdf
Data publikacji:
2017
Wydawca:
Uniwersytet Warmińsko-Mazurski w Olsztynie / Polskie Towarzystwo Magnezologiczne im. Prof. Juliana Aleksandrowicza
Tematy:
grasslands
legumes
herbs
calcium
phosphorus
Ca:P
Opis:
Green fodder plays a key role in nutrition of ruminants, and its quality is determined by the species composition of meadow and pasture swards. Legumes and herbs are generally more abundant in nutrients, especially minerals, than grasses. Calcium (Ca) and phosphorus (P) are particularly important for animal health. The dietary levels of Ca and P should be balanced to increase their availability and utilization. The aim of this study was to determine the content of calcium and phosphorus and the Ca:P ratio in selected legume and herb species from extensively used grasslands in the Olsztyn Lakeland. The study covered the following species of leguminous plants: Trifolium pratense, Trifolium repens, Lotus corniculatus, Lathyrus pratensis, Lotus uliginosus and Vicia cracc, and herbaceous plants: Taraxacum officinale, Achillea millefolium, Plantago lanceolata, Alchemilla vulgaris, Heracleum sibiricum and Cirsium oleraceum. The investigated legumes and herbs differed significantly in their Ca and P content and the Ca: P ratio. All the species were abundant in Ca, and two taxa: Cirsium oleraceum and Heracleum sibiricum, were characterized by particularly high levels of calcium. The highest levels of phosphorus were noted in Heracleum sibiricum, whereas the lowest content of P was determined in Alchemilla vulgaris, Cirsium oleraceum and Trifolium pratense. Cirsium oleraceum was abundant in Ca and deficient in P, hence it was distinguished by the widest Ca:P ratio. Legumes and herbs are valuable components of meadow sward and a rich source of minerals, in particular Ca, in animal diets.
Źródło:
Journal of Elementology; 2017, 22, 2; 663-669
1644-2296
Pojawia się w:
Journal of Elementology
Dostawca treści:
Biblioteka Nauki
Artykuł
Wyświetlanie 1-15 z 153

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