- Tytuł:
- Preparation and quality control of lutetium-177 bleomycin as a possible therapeutic agent
- Autorzy:
-
Yousefnia, H.
Jalilian, A. R.
Zolghadri, S.
Bahrami-Samani, A.
Shirvani-Arani, S.
Ghannadi-Maragheh, M. - Powiązania:
- https://bibliotekanauki.pl/articles/148628.pdf
- Data publikacji:
- 2010
- Wydawca:
- Instytut Chemii i Techniki Jądrowej
- Tematy:
-
bleomycin
Lu-177
biodistribution
radiolabeling - Opis:
- Due to interesting therapeutic properties of 177Lu and antineoblastic antibiotic, bleomycin (BLM), 177Lu-bleomycin (177Lu-BLM) was developed as a possible therapeutic compound. Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of a natural Lu2O3 sample with a thermal neutron flux of 4 × 1013 nźcm-2źs-1. The product was converted into chloride form which was further used for labeling of BLM. In optimized conditions a radiochemical purity of 98% was obtained for 177Lu-BLM shown by instant thin-layer chromatography (ITLC) (specific activity, 740 GBq/mmole). Biodistribution studies of Lu-177 chloride and 177Lu-BLM were performed in wild-type rats. The accumulation of the radiolabeled compound in lungs, liver and spleen demonstrates a pattern similar to the other radiolabeled bleomycins. Lu-BLM is a possible therapeutic agent in human malignancies and the efficacy of the compound should be tested in various tumor-bearing models.
- Źródło:
-
Nukleonika; 2010, 55, 3; 285-291
0029-5922
1508-5791 - Pojawia się w:
- Nukleonika
- Dostawca treści:
- Biblioteka Nauki
Artykuł