- Tytuł:
-
Szczepionka przeciwko afrykańskiemu pomorowi świń
Vaccine against African swine fever - Autorzy:
-
Pejsak, Zygmunt
Truszczyński, Marian - Powiązania:
- https://bibliotekanauki.pl/articles/22019768.pdf
- Data publikacji:
- 2020
- Wydawca:
- Krajowa Izba Lekarsko-Weterynaryjna
- Tematy:
-
trzoda chlewna
szczepienia ochronne
szczepionki atenuowane
szczepionki zabite
badania naukowe
choroby zwierząt
afrykański pomór świń
zwalczanie chorób zwierząt
szczepionki żywe
bezpieczeństwo
skuteczność
African swine fever
live vaccines
swine
wild boar
safety - Opis:
- African swine fever (ASF), occurring for many years, is at present the most significant viral disease of swine and wild boar. Despite of the situation, defined as a large epidemic or even pandemic, a vaccine is not yet available, It has been claimed that live, attenuated anti-ASF vaccines are most promising products on the way to control the disease. However the safe and effective vaccine is yet to be obtained. The current status in the field of ASFV vaccine development is encouraging, since ASFV strain(s) have been obtained, that have their virulence genes deleted. Deletion of ASFV genes that inhibit host antiviral type I interferon responses is considered as the most effective strategy to attenuate the virus. Deleted, live vaccinal strain(s) are still able to replicate and encode immunogenic antigens thus induce protective immunity in swine. However, a licensed cell line in which live, attenuated virus (LAV) can be propagated and produced on a large scale, is still not available. Concerning wild boar, the natural reservoir of ASFV, while developing live vaccine for swine protection, rigorous conditions for its safety and efficacy are strongly required.
- Źródło:
-
Życie Weterynaryjne; 2020, 95, 06; 358-361
0137-6810 - Pojawia się w:
- Życie Weterynaryjne
- Dostawca treści:
- Biblioteka Nauki
Artykuł