- Tytuł:
- Pentoxifylline and its active metabolite lisofylline attenuate transforming growth factor β1-induced asthmatic bronchial fibroblast-to-myofibroblast transition
- Autorzy:
-
Wójcik-Pszczoła, Katarzyna
Hińcza, Kinga
Wnuk, Dawid
Kądziołka, Dominika
Koczurkiewicz, Paulina
Sanak, Marek
Madeja, Zbigniew
Pękala, Elżbieta
Michalik, Marta - Powiązania:
- https://bibliotekanauki.pl/articles/1038759.pdf
- Data publikacji:
- 2016
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
theophylline
pentoxifylline
lisofylline
transforming growth factor type β
fibroblast-to-myofibroblast transition
asthma - Opis:
- Bronchial asthma is characterized by persistent airway inflammation and airway wall remodeling. Among many different cells and growth factors triggering changes in bronchi structure, transforming growth factor β1-induced fibroblast to myofibroblast transition is believed to be very important. The aim of this study was to evaluate whether theophylline (used in asthma therapy) and two other methylxanthines (pentoxifylline and its active metabolite lisofylline), may affect transforming growth factor β1-induced fibroblast to myofibroblast transition in bronchial fibroblasts derived from asthmatic patients. We show here for the first time that selected methylxanthines effectively reduce transforming growth factor β1-induced myofibroblast formation in asthmatic bronchial fibroblast populations. PTX was found to be the most effective methylxanthine. The number of differentiated myofibroblasts after PTX, LSF and THEO administration was reduced at least twofold. Studies on the use of methylxanthines opens a new perspective in the development of novel strategies in asthma therapy through their two-pronged, anti-inflammatory and anti-fibrotic action. In the future they can be considered as promising anti-fibrotic drugs.
- Źródło:
-
Acta Biochimica Polonica; 2016, 63, 3; 437-442
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł