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    Wyświetlanie 1-5 z 5
    Tytuł:
    Cytotoxicity of β-carotene cleavage products and its prevention by antioxidants
    Autorzy:
    Alija, Avdulla
    Bresgen, Nikolaus
    Bojaxhi, Ekramije
    Vogl, Cornelia
    Siems, Werner
    Eckl, Peter
    Powiązania:
    https://bibliotekanauki.pl/articles/1040406.pdf
    Data publikacji:
    2010
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    β-carotene cleavage products
    necrosis
    antioxidants
    apoptosis
    hepatocytes
    Opis:
    When we investigated the genotoxicity of β-carotene cleavage products (CPs) in primary rat hepatocytes stimulated to proliferate, we observed dose-dependent increases of chromosomal aberrations, sister chromatid exchanges and micronuclei. In contrast to other genotoxic substances, however, this increased genotoxicity was not accompanied by increased cytotoxicity. As a consequence we observed metaphases showing massive chromosomal damage, indicating inhibition of apoptosis by CPs enabling these cells to proceed in the cell cycle. Since proliferative stimulation by growth factors may support this effect, the in vitro toxicological effects of CPs were studied on proliferatively quiescent primary rat hepatocytes. A significant increase of both apoptosis and necrosis was found. Supplementation with antioxidants did not significantly lower the level of apoptosis, while the level of necrosis was significantly reduced by Trolox and N-acetylcysteine at all concentrations tested as well as ascorbic acid (50 µM) and a combination of Trolox (50 µM) and ascorbic acid (50 µM). These observations indicate that a) the cytotoxic potential in combination with the genotoxic potential of CPs may promote the initiation of cells due to compensatory cell division in exposed tissues and may aggravate inflammatory processes under chronic exposure, and b) the applied antioxidants may protect from cytotoxicity primarily via the detoxification of aldehydic β-carotene cleavage products.
    Źródło:
    Acta Biochimica Polonica; 2010, 57, 2; 217-221
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Effects of olive leaf polyphenols against H2O2 toxicity in insulin secreting β-cells
    Autorzy:
    Cumaoğlu, Ahmet
    Rackova, Lucia
    Stefek, Milan
    Kartal, Murat
    Maechler, Pierre
    Karasu, Çimen
    Powiązania:
    https://bibliotekanauki.pl/articles/1039946.pdf
    Data publikacji:
    2011
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    olive
    glucose
    insulin
    hydrogen peroxide
    polyphenol
    apoptosis
    β-cells
    oxidative stress
    oleuropein
    Opis:
    In pancreatic β-cells, although H2O2 is a metabolic signal for glucose stimulated insulin secretion, it may induce injury in the presence of increased oxidative stress (OS) as in the case of diabetic chronic hyperglycemia. Olea europea L. (olive) leaves contain polyphenolic compounds that may protect insulin-secreting cells against OS. The major polyphenolic compound in ethanolic olive leaf extract (OLE) is oleuropein (about 20 %), thus we compared the effects of OLE with the effects of standard oleuropein on INS-1 cells. The cells were incubated with increasing concentrations of OLE or oleuropein for 24 h followed by exposure to H2O2 (0.035 mM) for 45 min. H2O2 alone resulted in a significantly decreased viability (MTT assay), depressed glucose-stimulated insulin secretion, increased apoptotic and necrotic cell death (AO/EB staining), inhibited glutathione peroxidase activity (GPx) and stimulated catalase activity that were associated with increased intracellular generation of reactive oxygen species (ROS) (fluorescence DCF). OLE and oleuropein partly improved the viability, attenuated necrotic and apoptotic death, inhibited the ROS generation and improved insulin secretion in H2O2-exposed cells. The effects of oleuropein on insulin secretion were more pronounced than those of OLE, while OLE exerted a stronger anti-cytotoxic effect than oleuropein. Unlike OLE, oleuropein had no significant preserving effect on GPx; however, both compounds stimulated the activity of catalase in H2O2-exposed cells. These findings indicate different modulatory roles of polyphenolic constituents of olive leaves on redox homeostasis that may have a role in the maintenance of β-cell physiology against OS.
    Źródło:
    Acta Biochimica Polonica; 2011, 58, 1; 45-50
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Antiproliferative effect of β-escin - an in vitro study
    Autorzy:
    Mojžišová, Gabriela
    Kello, Martin
    Pilátová, Martina
    Tomečková, Vladimíra
    Vašková, Janka
    Vaško, Ladislav
    Bernátová, Silvia
    Mirossay, Ladislav
    Mojžiš, Ján
    Powiązania:
    https://bibliotekanauki.pl/articles/1038845.pdf
    Data publikacji:
    2016
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    escin
    apoptosis
    mitochondria
    fluorescence fingerprint
    Opis:
    This study examined the antiproliferative effects of β-escin (E) in cancer cells. The study showed that E inhibited cancer cells growth in a dose-dependent manner. The flow cytometric analysis revealed an escin-induced increase in the sub-G1 DNA content, which is considered to be a marker of apoptosis. Apoptosis was also confirmed by annexin V staining and DNA fragmentation assay. These effects were associated with increased generation of reactive oxygen species (ROS), caspase-3 activation and decreased mitochondrial membrane potential (MMP). Moreover, escin decreased mitochondrial protein content and mitochondrial fluorescence intensity as well as caused depletion of glutathione (GSH). However, activity of glutathione peroxidase (GPx) and glutathione reductase (GR) was not significantly changed in escin-treated cells. In conclusion, our results demonstrated that E has apoptotic effects in human cancer cells through the mechanisms involving mitochondrial perturbation. Although the exact mechanism needs to be investigated further, it can be concluded that E may be a useful candidate agent for cancer treatment.
    Źródło:
    Acta Biochimica Polonica; 2016, 63, 1; 79-87
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Low-glucose medium induces ORP150 expression and exerts inhibitory effect on apoptosis and senescence of human breast MCF7 cells
    Autorzy:
    Krętowski, Rafał
    Stypułkowska, Anna
    Cechowska-Pasko, Marzanna
    Powiązania:
    https://bibliotekanauki.pl/articles/1039569.pdf
    Data publikacji:
    2013
    Wydawca:
    Polskie Towarzystwo Biochemiczne
    Tematy:
    β-galactosidase
    senescence
    ORP150
    apoptosis
    Opis:
    Glucose deprivation is a factor evoking endoplasmic reticulum (ER) stress and induction of expression of an oxygen-regulated protein of 150 kDa (ORP150). We studied the effect of inducible overexpression of ORP150 on senescence and apoptosis of human breast carcinoma cells (MCF7) and human skin fibroblasts. We found an inhibitory effect of ORP150 on apoptosis and senescence of MCF7 cells, but not fibroblasts in ER stress conditions. An increased expression of senescence-associated β-galactosidase and acid β-galactosidase activity (biomarkers of cellular senescence) was observed. We suggest that ORP150 induction in cancer cells can promote tumour progression and may be a major cause of their resistance to chemotherapeutics.
    Źródło:
    Acta Biochimica Polonica; 2013, 60, 2; 167-173
    0001-527X
    Pojawia się w:
    Acta Biochimica Polonica
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Esculetin Attenuates Neurotoxicity Induced by Aβ25-35 in SH-SY5Y Cells via inhibiting Oxidative Stress and Mitochondria-mediated Apoptosis
    Autorzy:
    Gao, Jun-Li
    Gong, Xiao-Ying
    Powiązania:
    https://bibliotekanauki.pl/articles/895539.pdf
    Data publikacji:
    2018-10-31
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    apoptosis
    oxidative stress
    Alzheimer’s disease
    esculetin
    SH-SY5Y cells
    Opis:
    Alzheimer’s disease (AD) is a neurodegenerative disease afflicting many people worldwide. As the specific biomarker, beta amyloid (Aβ) is considered to serve a central role in the progress of AD. To discover effective therapy for AD, esculetin was investigated using SH-SY5Y cells to evaluate its protective effects against the neurotoxicity induced by Aβ25-35. As a result, esculetin can improve the viability of SH-SY5Y cells injured by Aβ25-35 (58.0%, 66.1% and 82.1% at 0.1, 1 and 10 μM vs 49.5% at 0 μM). Further investigation has demonstrated the protective effects of esculetin at different concetrations of 0.1, 1 and 10 μM are associated with its inhibition of oxidative stress and apoptosis in SH-SY5Y cells, which is more observable especially at both 1 and 10 μM. These observations can give evidences for the following investigation in vivo and discovery of novel preventive method for AD.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 5; 1177-1185
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-5 z 5

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