Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

English (EN)·Polski (PL)·Yкраїнський (UK)
Przejdź do strony domowej biblioteki Centralna Biblioteka Wojskowa Link otwiera się w nowym oknie Logo biblioteki Prolib Integro - strona głównaCentralna Biblioteka Wojskowa

Wyszukujesz frazę "cytotoxic" wg kryterium: Temat

  Lista filtrów
Wyrównaj
    Wyświetlanie 1-3 z 3
    Tytuł:
    ASSESSMENTS OF ANTIOXIDANT CONTENT AND THE ANTI-CARCINOGENIC EFFECT OF EXTRACTS OF SOLANUM ROSTRATUM DUNAL IN HUMAN CANCER CELLS
    Autorzy:
    Valadez Vega, María del Carmen
    Izquierdo Vega, Jeannett Alejandra
    Villagómez Ibarra, Jose Roberto
    Sánchez Gutiérrez, Manuel
    Madrigal Santillán, Eduardo Osiris
    Morales Gonzalez, Jose Antonio
    Bautista Ávila, Mirandeli
    García Velasco, Laura
    Powiązania:
    https://bibliotekanauki.pl/articles/895384.pdf
    Data publikacji:
    2019-06-28
    Wydawca:
    Polskie Towarzystwo Farmaceutyczne
    Tematy:
    antioxidant
    cytotoxic
    Solanum rostratum
    SiHa cell line
    MDA cell line
    Opis:
    In Mexico, Solanum rostratum has been employed for the treatment of several diseases, including uterine cancer. The aim of this study was to evaluate the antioxidant and anti-carcinogenic activity of extracts of Solanum rostratum Dunal on MDA and SiHa cell lines. The methanolic, ethyl acetate, and hexane extracts of the aerial parts of Solanum rostratum were tested for phenols concentration, antioxidant activity, and anti-carcinogenic effect. The leaves extracts showed the highest content of phenols; however the flower-fruits extracts showed higher scavenging activity. On the other hand, ethyl acetate extracts exhibited the highest anti-carcinogenic effect, while methanolic extracts showed the least effect. The results of this work indicated that Solanum rostratum is a promising source of antioxidants, and the extracts exert a dose-dependent anti-carcinogenic effect on both cell lines.
    Źródło:
    Acta Poloniae Pharmaceutica - Drug Research; 2019, 76, 3; 493-502
    0001-6837
    2353-5288
    Pojawia się w:
    Acta Poloniae Pharmaceutica - Drug Research
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    Exploring the potential of Inula viscosa extracts for antioxidant, antiproliferative and apoptotic effects on human liver cancer cells and a molecular docking study
    Autorzy:
    Kheyar-Kraouche, Naoual
    Boucheffa, Saliha
    Bellik, Yuva
    Farida, Kheyar
    Brahmi-Chendouh, Nabila
    Powiązania:
    https://bibliotekanauki.pl/articles/16706188.pdf
    Data publikacji:
    2023
    Wydawca:
    Polska Akademia Nauk. Czasopisma i Monografie PAN
    Tematy:
    Inula viscosa leaf extracts
    antioxidant
    cytotoxic effect
    HepG2 cells
    ROS
    molecular docking
    Opis:
    In folk medicine, Inula viscosa (Asteraceae) has been traditionally utilized for treating various ailments, including diabetes, bronchitis, diarrhea, rheumatism, and injuries. In this study, we aimed to investigate the chemical composition, antioxidant, antiproliferative, and apoptotic properties of I. viscosa leaf extracts. Extraction was performed using solvents of varying polarities. Antioxidant activity was determined using Ferric reducing antioxidant power (FRAP) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. The results revealed that aqueous ethanol (70%) and aqueous ethyl acetate (70%) extracts contained high levels of phenols (645.58 ± 8.77 mg CE/g) and flavonoids (180.69 ± 1.54 mg QE/g), respectively. Aqueous ethanol (70%) extract exhibited the highest antioxidant activity with IC50 of 572.74 μmol TE/g DW (μmol Trolox equivalent in 1g of dry extract) in the ABTS assay and 76 862.06 μM TE/g DW in the FRAP test. All extracts showed a considerable dose-dependent cytotoxic effect on cancerous HepG2 cells (P < 0.05). The aqueous ethanol extract demonstrated the highest inhibitory effect (IC50 = 1.67 mg/ml). Treatment with aqueous ethanol (70%) and pure ethyl acetate extracts significantly increased the number of apoptotic cells to 8 and 6%, respectively, in HepG2 cells (P < 0.05). Additionally, the aqueous ethanol extract significantly elevatedreactive oxygen species (ROS) levels (53%) in HepG2 cells. The molecular docking study identified paxanthone and banaxanthone E as the compounds that exhibited the highest binding affinities with BCL-2. This study demonstrated the potent antioxidant, antiproliferation, and intracellular ROS production of I. viscosa leaf extracts. Further studies should be conducted to identify the active compounds involved.
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2023, 104, 2; 183-198
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
    Tytuł:
    In vitro cultures of carnivorous plants from the Drosera and Dionaea genus for the production of biologically active secondary metabolites
    Autorzy:
    Banasiuk, R.
    Kawiak, A.
    Krolicka, A.
    Powiązania:
    https://bibliotekanauki.pl/articles/80172.pdf
    Data publikacji:
    2012
    Wydawca:
    Polska Akademia Nauk. Czytelnia Czasopism PAN
    Tematy:
    antimicrobial activity
    antioxidant
    cytotoxic activity
    flavonoids
    micropropagation
    naphthoquinone
    in vitro culture
    carnivorous plant
    Drosera
    extract
    phytotherapy
    pulmonary disease
    cough
    biological activity
    secondary metabolite
    Źródło:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology; 2012, 93, 2
    0860-7796
    Pojawia się w:
    BioTechnologia. Journal of Biotechnology Computational Biology and Bionanotechnology
    Dostawca treści:
    Biblioteka Nauki
    Artykuł
      Wyświetlanie 1-3 z 3

      Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies