- Tytuł:
- Occupational exposure to antineoplastic drugs in hospital environments: potential risk associated with contact with cyclophosphamide- and ifosfamide-contaminated surfaces
- Autorzy:
-
Mucci, Nicola
Dugheri, Stefano
Farioli†, Andrea
Garzaro, Giacomo
Rapisarda, Venerando
Campagna, Marcello
Bonari, Alessandro
Arcangeli, Giulio - Powiązania:
- https://bibliotekanauki.pl/articles/2085717.pdf
- Data publikacji:
- 2020-09-24
- Wydawca:
- Instytut Medycyny Pracy im. prof. dra Jerzego Nofera w Łodzi
- Tematy:
-
occupational exposure
cyclophosphamide
antineoplastic drugs
ifosfamide
wipe test
surface contamination - Opis:
- BackgroundCyclophosphamide (CP) and ifosfamide (IP) contaminations have been detected in hospital environments. This study was conducted to determine if there was any contamination in the spaces (floors and door handles) between the hospital exit and the antineoplastic drugs (ADs) preparation and administration units. At the same time, the authors proposed a new automation of the analytical procedure to considerably decrease the time needed for sample preparation and analysis.Material and MethodsTo evaluate the ADs contamination of surfaces, 829 wipe tests were performed in a campaign involving 3 hospitals located in Italy. Sampling was performed using an innovative kit. The levels of ADs were measured in each wipe sample using liquid chromatography/triple quadrupole.ResultsOn-line solid-phase extraction guarantees the construction of a robust and reproducible analytical method. The CP and IP recoveries from stainless steel, polycarbonate and polyvinyl chloride ranged >80%, and the wipe holders and the automation tested ensured desorption efficiencies close to 100% for both the ADs. Of the 552 wipes taken on the spaces between the hospital exit and the preparation, administration and pharmacy warehouse units, 22 were greater than or equal to the limit of quantification, all adjacent to the administration units.ConclusionsThis study provides an insight into the exposure situation against ADs residues. In order to improve environmental monitoring programs, the authors propose to evaluate the ADs contamination also outside the preparation, administration and pharmacy warehouse units.
- Źródło:
-
Medycyna Pracy; 2020, 71, 5; 519-529
0465-5893
2353-1339 - Pojawia się w:
- Medycyna Pracy
- Dostawca treści:
- Biblioteka Nauki
Artykuł