- Tytuł:
- Some heterocyclic thione derivatives exhibit anticoccidial activity by inhibiting glycosidases
- Autorzy:
-
Balbaa, Mahmoud
Abd El-Hady, Neama
Taha, Nabil
El Ashry, El Sayed - Powiązania:
- https://bibliotekanauki.pl/articles/1039655.pdf
- Data publikacji:
- 2012
- Wydawca:
- Polskie Towarzystwo Biochemiczne
- Tematy:
-
inhibitor of glycosidase
anticoccidial compounds
Coccocidiosis
imidazolethione
triazolethiol
toltrazuril - Opis:
- Coccidiosis is one of the most common parasitic diseases affecting many species of domestic animals. This disease has a major economic significance and the search for new compounds having anticoccidial activity is of great importance. In this article, different levels of protection from coccidian infection by Eimeria stiedae were developed in rabbits by treatment with compounds incorporating the skeleton of thiourea. These compounds include 4,5-diphenylimidazole-2-thione (1), 4,5-Diphenyl-1,2,4-triazole-3-thiol (2) and 5-(2-Hydroxyphenyl)-4-phenyl-1,2,4-triazole-3-thiol (3) compared to the anticoccidial drug toltrazuril as a reference compound. Compounds 1-3 inhibit coccidiosis-induced activity of α-glucosidase. The protection from coccidial infection by compound 1 was higher than that shown for compounds 2 and 3. These data suggest that diazole and triazole thione derivatives have a mimetic effect for anticoccidial drugs through their inhibition of glycosidases.
- Źródło:
-
Acta Biochimica Polonica; 2012, 59, 4; 575-580
0001-527X - Pojawia się w:
- Acta Biochimica Polonica
- Dostawca treści:
- Biblioteka Nauki
Artykuł