- Tytuł:
- Synthesis and anticancer activity evaluation of novel derivatives of 7-amino-4-methylquinolin-2(1H)-one
- Autorzy:
-
Kubica, Krzysztof P.
Taciak, Przemyslaw P.
Czajkowska, Agnieszka
Sztokfisz-Ignasiak, Alicja
Wyrebiak, Rafal
Mlynarczuk-Bialy, Izabela
Malejczyk, Jacek
Mazurek, Aleksander P. - Powiązania:
- https://bibliotekanauki.pl/articles/895717.pdf
- Data publikacji:
- 2018-08-31
- Wydawca:
- Polskie Towarzystwo Farmaceutyczne
- Tematy:
-
anticancer activity
cytotoxicity assay
cell migration assay
quinolin-2(1H)-one - Opis:
- In this study we designed and synthesized sixteen new derivatives of 7-amino-4-methylquinolin-2(1H)-one with potential anticancer activity. The structures of synthesized compounds were confirmed by 1H and 13C NMR. The activity of novel substances was evaluated by cell viability assay and wound healing assay. In vitro tests for series of sixteen novel compounds were performed. The results showed that examined compounds are selective for cancer cells, but their activity for various types of cancer is different. Three of new compounds presented ability to inhibit cells migration. The novel compounds constitute a good starting point for further studies and optimization of structure for new therapeutically effective anti-cancerous drugs. Seven compounds, which showed the highest rate of cell inhibition, were selected for further studies.
- Źródło:
-
Acta Poloniae Pharmaceutica - Drug Research; 2018, 75, 4; 903-910
0001-6837
2353-5288 - Pojawia się w:
- Acta Poloniae Pharmaceutica - Drug Research
- Dostawca treści:
- Biblioteka Nauki
Artykuł